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Permanent cardiac sarcomere changes in a rabbit model of intrauterine growth restriction

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dc.contributor.author Torre, Iratxe
dc.contributor.author González-Tendero, Anna
dc.contributor.author García Cañadilla, Patricia, 1985-
dc.contributor.author Crispi Brillas, Fàtima
dc.contributor.author García-García, Francesc Josep
dc.contributor.author Bijnens, Bart
dc.contributor.author Iruretagoyena, Igor
dc.contributor.author Dopazo, Joaquín
dc.contributor.author Amat-Roldán, Iván
dc.contributor.author Gratacós Solsona, Eduard
dc.date.accessioned 2016-02-18T14:26:18Z
dc.date.available 2016-02-18T14:26:18Z
dc.date.issued 2014
dc.identifier.citation Torre I, Gonzalez-Tendero A, Garcia-Canadilla P, Crispi F, Garcia-GarciA F, Bijnens B, Iruretagoyena I, Dopazo J, Amat-Roldan I, Gratacos E. Permanent cardiac sarcomere changes in a rabbit model of intrauterine growth restriction. PLoS ONE. 2014;9(11):1-8. DOI: 10.1371/journal.pone.0113067.
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/25885
dc.description.abstract Background: Intrauterine growth restriction (IUGR) induces fetal cardiac remodelling and dysfunction, which persists postnatally and may explain the link between low birth weight and increased cardiovascular mortality in adulthood. However, the cellular and molecular bases for these changes are still not well understood. We tested the hypothesis that IUGR is associated with structural and functional gene expression changes in the fetal sarcomere cytoarchitecture, which remain present in adulthood./nMethods and Results: IUGR was induced in New Zealand pregnant rabbits by selective ligation of the utero-placental vessels. Fetal echocardiography demonstrated more globular hearts and signs of cardiac dysfunction in IUGR. Second harmonic generation microscopy (SHGM) showed shorter sarcomere length and shorter A-band and thick-thin filament interaction lengths, that were already present in utero and persisted at 70 postnatal days (adulthood). Sarcomeric M-band (GO: 0031430) functional term was over-represented in IUGR fetal hearts./nConclusion: The results suggest that IUGR induces cardiac dysfunction and permanent changes on the sarcomere.
dc.description.sponsorship This study was supported by grants from Ministerio de Economia y Competitividad PN de I+D+I 2008-2011 (ref. SAF2009_08815, SAF2012-37196, and BIO2011-27069); Instituto de Salud Carlos III (ref. PI11/00051, PI11/01709, PI12/00801) cofinanciado por el Fondo Europeo de Desarrollo Regional de la Unión Europea “Una manera de hacer Europa”; Centro para el Desarrollo Técnico Industrial (ref. cvREMOD 2009-2012) apoyado por el Ministerio de Economia y Competitividad y Fondo de inversión local para el empleo, Spain; The Cerebra Foundation for the Brain Injured Child (Carmarthen, Wales, UK); Obra Social “La Caixa” (Spain); Fundació Mutua Madrileña (Spain); Fundació Agrupació Mutua (Spain); AGAUR 2009 SGR grant n° 1099; and Red Temática de Investigación Cooperativa en cancer (ref. RD06/0020/1019). I.T. was supported by a post-doctoral fellowship from Carlos III Institute of Health, Spain (CD08/00176) during the time these studies were performed. P.G.C. acknowledges grant support to the Programa de Ayudas Predoctorales de Formación en Investigación en Salud del Instituto Carlos III, Spain (FI12/00362). A.G.T. was supported by an IDIBAPS (Institut d'Investigacions Biomèdiques August Pi i Sunyer) pre-doctoral fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartof PLoS ONE. 2014;9(11):1-8
dc.rights © 2014 Torre et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.title Permanent cardiac sarcomere changes in a rabbit model of intrauterine growth restriction
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0113067
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2012-37196
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2009_08815
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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