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Reversible cysteine oxidation in hydrogen peroxide sensing and signal transduction

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dc.contributor.author García Santamarina, Sarela, 1978-
dc.contributor.author Boronat i Llop, Susanna, 1965-
dc.contributor.author Hidalgo Hernando, Elena
dc.date.accessioned 2016-01-13T15:06:38Z
dc.date.available 2016-01-13T15:06:38Z
dc.date.issued 2014
dc.identifier.citation García-Santamarina S, Boronat S, Hidalgo E. Reversible cysteine oxidation in hydrogen peroxide sensing and signal transduction. Biochemistry. 2014;53(16):2560-80. DOI: 10.1021/bi401700f
dc.identifier.issn 0006-2960
dc.identifier.uri http://hdl.handle.net/10230/25566
dc.description.abstract Activation of redox cascades through hydrogen peroxide-mediated reversible cysteine oxidation is a major mechanism for intracellular signaling. Understanding why some cysteine residues are specifically oxidized, in competition with other proximal cysteine residues and in the presence of strong redox buffers, is therefore crucial for understanding redox signaling. In this review, we explore the recent advances in thiol-redox chemistry linked to signaling. We describe the last findings in the field of redox sensors, those that are naturally present in different model organisms as well as those that have been engineered to quantify intracellular hydrogen peroxide concentrations. Finally, we provide a summary of the newest approaches developed to study reversible cysteine oxidation at the proteomic level.
dc.description.sponsorship This work was supported by the Spanish Ministry of Science and Innovation (BFU2012-32045), PLAN E and FEDER, by the Spanish program Consolider-Ingenio 2010 Grant CSD 2007-0020, and by Grant SGR2009-195 from Generalitat de Catalunya (Spain) to E.H. E.H. is the recipient of an ICREA Academia Award (Generalitat de Catalunya).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher American Chemical Society
dc.relation.ispartof Biochemistry. 2014;53(16):2560-80
dc.rights © American Chemical Society after peer review and technical editing by the publisher./nTo access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/bi401700f
dc.subject.other Oxigen actiu
dc.subject.other Proteòmica
dc.title Reversible cysteine oxidation in hydrogen peroxide sensing and signal transduction
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1021/bi401700f
dc.subject.keyword Redox biology
dc.subject.keyword H2O2 reactivity
dc.subject.keyword Cys oxidation
dc.subject.keyword H2O2 sensor
dc.subject.keyword Redox proteomics
dc.subject.keyword Pap1
dc.subject.keyword Yap1
dc.subject.keyword OxyR
dc.subject.keyword Nrf2
dc.subject.keyword roGFP
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-32045
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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