Reversible cysteine oxidation in hydrogen peroxide sensing and signal transduction

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• dc.contributor.author García Santamarina, Sarela, 1978-ca
• dc.contributor.author Boronat i Llop, Susanna, 1965-ca
• dc.contributor.author Hidalgo Hernando, Elenaca
• dc.date.accessioned 2016-01-13T15:06:38Z
• dc.date.available 2016-01-13T15:06:38Z
• dc.date.issued 2014
• dc.description.abstract Activation of redox cascades through hydrogen peroxide-mediated reversible cysteine oxidation is a major mechanism for intracellular signaling. Understanding why some cysteine residues are specifically oxidized, in competition with other proximal cysteine residues and in the presence of strong redox buffers, is therefore crucial for understanding redox signaling. In this review, we explore the recent advances in thiol-redox chemistry linked to signaling. We describe the last findings in the field of redox sensors, those that are naturally present in different model organisms as well as those that have been engineered to quantify intracellular hydrogen peroxide concentrations. Finally, we provide a summary of the newest approaches developed to study reversible cysteine oxidation at the proteomic level.ca
• dc.description.sponsorship This work was supported by the Spanish Ministry of Science and Innovation (BFU2012-32045), PLAN E and FEDER, by the Spanish program Consolider-Ingenio 2010 Grant CSD 2007-0020, and by Grant SGR2009-195 from Generalitat de Catalunya (Spain) to E.H. E.H. is the recipient of an ICREA Academia Award (Generalitat de Catalunya).
• dc.format.mimetype application/pdfca
• dc.identifier.citation García-Santamarina S, Boronat S, Hidalgo E. Reversible cysteine oxidation in hydrogen peroxide sensing and signal transduction. Biochemistry. 2014;53(16):2560-80. DOI: 10.1021/bi401700fca
• dc.identifier.doi http://dx.doi.org/10.1021/bi401700f
• dc.identifier.issn 0006-2960
• dc.identifier.uri http://hdl.handle.net/10230/25566
• dc.language.iso engca
• dc.publisher American Chemical Societyca
• dc.relation.ispartof Biochemistry. 2014;53(16):2560-80
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2012-32045
• dc.rights © American Chemical Society after peer review and technical editing by the publisher./nTo access the final edited and published work see http://pubs.acs.org/doi/abs/10.1021/bi401700fca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.keyword Redox biology
• dc.subject.keyword H2O2 reactivity
• dc.subject.keyword Cys oxidation
• dc.subject.keyword H2O2 sensor
• dc.subject.keyword Redox proteomics
• dc.subject.keyword Pap1
• dc.subject.keyword Yap1
• dc.subject.keyword OxyR
• dc.subject.keyword Nrf2
• dc.subject.keyword roGFP
• dc.subject.other Oxigen actiuca
• dc.subject.other Proteòmicaca
• dc.title Reversible cysteine oxidation in hydrogen peroxide sensing and signal transductionca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/acceptedVersionca