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The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms

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dc.contributor.author Ruiz Roig, Clàudia
dc.contributor.author Noriega Esteban, Núria
dc.contributor.author Duch, Alba
dc.contributor.author Posas Garriga, Francesc
dc.contributor.author Nadal Clanchet, Eulàlia de
dc.date.accessioned 2015-12-11T14:57:25Z
dc.date.available 2015-12-11T14:57:25Z
dc.date.issued 2012
dc.identifier.citation Ruiz-Roig C, Noriega N, Duch A, Posas F, de Nadal E. The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms. Molecular biology of the cell. 2012;23(21):4286-96. DOI 10.1091/mbc.E12-04-0289
dc.identifier.issn 1059-1524
dc.identifier.uri http://hdl.handle.net/10230/25391
dc.description.abstract Cells modulate expression of nuclear genes in response to alterations in mitochondrial function, a response termed retrograde (RTG) regulation. In budding yeast, the RTG pathway relies on Rtg1 and Rtg3 basic helix-loop-helix leucine Zipper transcription factors. Exposure of yeast to external hyperosmolarity activates the Hog1 stress-activated protein kinase (SAPK), which is a key player in the regulation of gene expression upon stress. Several transcription factors, including Sko1, Hot1, the redundant Msn2 and Msn4, and Smp1, have been shown to be directly controlled by the Hog1 SAPK. The mechanisms by which Hog1 regulates their activity differ from one to another. In this paper, we show that Rtg1 and Rtg3 transcription factors are new targets of the Hog1 SAPK. In response to osmostress, RTG-dependent genes are induced in a Hog1-dependent manner, and Hog1 is required for Rtg1/3 complex nuclear accumulation. In addition, Hog1 activity regulates Rtg1/3 binding to chromatin and transcriptional activity. Therefore Hog1 modulates Rtg1/3 complex activity by multiple mechanisms in response to stress. Overall our data suggest that Hog1, through activation of the RTG pathway, contributes to ensure mitochondrial function as part of the Hog1-mediated osmoadaptive response.
dc.description.sponsorship This work was supported by the Botin Foundation and grants from the Spanish Ministry of Science and Innovation (BFU2011-26722 to E.d.N. and BIO2009-07762 to F.P.) and the FP7 (UNICELLSYS) framework program.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher American Society for Cell Biology
dc.relation.ispartof Molecular biology of the cell. 2012;23(21):4286-96
dc.rights © 2012 Ruiz et al. This article is under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/3.0
dc.subject.other Saccharomyces cerevisiae -- Metabolisme
dc.subject.other Regulació genètica
dc.title The Hog1 SAPK controls the Rtg1/Rtg3 transcriptional complex activity by multiple regulatory mechanisms
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1091/mbc.E12-04-0289
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/201142
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BFU2011-26722
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2009-07762
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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