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Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain

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dc.contributor.author Delgado Rodríguez, Miguel
dc.contributor.author Castilla, Jesús
dc.contributor.author Godoy i García, Pere
dc.contributor.author Martín, Vicente
dc.contributor.author Soldevila, Núria
dc.contributor.author Alonso Caballero, Jordi
dc.contributor.author Astray, Jenaro
dc.contributor.author Baricot, Maretva
dc.contributor.author Galán, Juan Carlos
dc.contributor.author Castro, Ady
dc.contributor.author González Candela, Fernando
dc.contributor.author Mayoral, José María
dc.contributor.author Quintana, José María
dc.contributor.author Pumarola, Tomás
dc.contributor.author Tamames, Sonia
dc.contributor.author Sáez, Marc
dc.contributor.author Domínguez García, Àngela
dc.contributor.author CIBERESP Cases and Controls in Pandemic Influenza Working Group
dc.date.accessioned 2015-12-02T14:32:22Z
dc.date.available 2015-12-02T14:32:22Z
dc.date.issued 2013
dc.identifier.citation Delgado-Rodríguez M, Castilla J, Godoy P, Martín V, Soldevila N, Alonso J et al. Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain. Influenza and other respiratory viruses. 2013. 7(6): 1336-1342. DOI 10.1111/irv.12119
dc.identifier.issn 1750-2640
dc.identifier.uri http://hdl.handle.net/10230/25309
dc.description.abstract BACKGROUND: The present report compares prognosis in hospitalized cases with the H1N1 pandemic virus in two seasons. METHODS: Two series of hospitalized patients with laboratory-confirmed H1N1 pandemic influenza have been compared: 813 in the season 2009-2010 and 707 in the season 2010-2011. A detailed history of variables preceding hospital admission and during hospitalization was obtained by interview and clinical charts. A combined endpoint of death admission to intensive care was used as outcome due to the low number of deaths. Logistic regression was applied in the analysis for adverse outcome. RESULTS: Patients of the second season had different characteristics than in the first one (older, more underlying conditions, more malfunctioning organs and more symptoms). Patients with H1N1 pandemic virus when hospitalized were more frequently directly admitted to ICU during the 2010-2011 season than in the previous season (RR=2·10; 95% confidence intervals CI, 1·55-2·85), as a consequence of a higher presence of sepsis and respiratory distress. These patients also showed during hospitalization a higher risk of ICU admission or death (RR=3·22, 95% CI, 2·15-4·83). After adjusting for the differences in risk factors of adverse outcome, patients in the second season showed a higher risk of ICU admission and/or in-hospital death odds ratio (OR=3·77, 95% CI, 2·30-6·18). CONCLUSION: Hospitalized patients with H1N1 pandemic influenza during the second season were more severely affected at hospital admission and showed a worse prognosis than in previous season, independently of the differences found at hospital admission.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartof Influenza and other respiratory viruses. 2013. 7(6): 1336-1342
dc.rights All articles published in this journal are made available under the terms of the Creative Commons License.
dc.subject.other Grip A (H1N1)
dc.subject.other Epidemiologia
dc.subject.other Prognosi
dc.title Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1111/irv.12119
dc.subject.keyword Hospitalization
dc.subject.keyword Influenza
dc.subject.keyword Mortality
dc.subject.keyword Prognosis
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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