Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain
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- dc.contributor.author Delgado Rodríguez, Miguelca
- dc.contributor.author Castilla, Jesúsca
- dc.contributor.author Godoy i García, Pereca
- dc.contributor.author Martín, Vicenteca
- dc.contributor.author Soldevila, Núriaca
- dc.contributor.author Alonso Caballero, Jordica
- dc.contributor.author Astray, Jenaroca
- dc.contributor.author Baricot, Maretvaca
- dc.contributor.author Galán, Juan Carlosca
- dc.contributor.author Castro, Adyca
- dc.contributor.author González Candela, Fernandoca
- dc.contributor.author Mayoral, José Maríaca
- dc.contributor.author Quintana, José Maríaca
- dc.contributor.author Pumarola, Tomásca
- dc.contributor.author Tamames, Soniaca
- dc.contributor.author Sáez, Marcca
- dc.contributor.author Domínguez García, Àngelaca
- dc.contributor.author CIBERESP Cases and Controls in Pandemic Influenza Working Groupca
- dc.date.accessioned 2015-12-02T14:32:22Z
- dc.date.available 2015-12-02T14:32:22Z
- dc.date.issued 2013
- dc.description.abstract BACKGROUND: The present report compares prognosis in hospitalized cases with the H1N1 pandemic virus in two seasons. METHODS: Two series of hospitalized patients with laboratory-confirmed H1N1 pandemic influenza have been compared: 813 in the season 2009-2010 and 707 in the season 2010-2011. A detailed history of variables preceding hospital admission and during hospitalization was obtained by interview and clinical charts. A combined endpoint of death admission to intensive care was used as outcome due to the low number of deaths. Logistic regression was applied in the analysis for adverse outcome. RESULTS: Patients of the second season had different characteristics than in the first one (older, more underlying conditions, more malfunctioning organs and more symptoms). Patients with H1N1 pandemic virus when hospitalized were more frequently directly admitted to ICU during the 2010-2011 season than in the previous season (RR=2·10; 95% confidence intervals CI, 1·55-2·85), as a consequence of a higher presence of sepsis and respiratory distress. These patients also showed during hospitalization a higher risk of ICU admission or death (RR=3·22, 95% CI, 2·15-4·83). After adjusting for the differences in risk factors of adverse outcome, patients in the second season showed a higher risk of ICU admission and/or in-hospital death odds ratio (OR=3·77, 95% CI, 2·30-6·18). CONCLUSION: Hospitalized patients with H1N1 pandemic influenza during the second season were more severely affected at hospital admission and showed a worse prognosis than in previous season, independently of the differences found at hospital admission.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Delgado-Rodríguez M, Castilla J, Godoy P, Martín V, Soldevila N, Alonso J et al. Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spain. Influenza and other respiratory viruses. 2013. 7(6): 1336-1342. DOI 10.1111/irv.12119ca
- dc.identifier.doi http://dx.doi.org/10.1111/irv.12119
- dc.identifier.issn 1750-2640
- dc.identifier.uri http://hdl.handle.net/10230/25309
- dc.language.iso engca
- dc.publisher Wileyca
- dc.relation.ispartof Influenza and other respiratory viruses. 2013. 7(6): 1336-1342
- dc.rights All articles published in this journal are made available under the terms of the Creative Commons License.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.keyword Hospitalization
- dc.subject.keyword Influenza
- dc.subject.keyword Mortality
- dc.subject.keyword Prognosis
- dc.subject.other Grip A (H1N1)ca
- dc.subject.other Epidemiologiaca
- dc.subject.other Prognosica
- dc.title Different prognosis in hospitalized patients with influenza one season after the pandemic H1N1 influenza of 2009-2010 in Spainca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca