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Chromatin-bound IκB-alpha regulates a subset of polycomb target genes in differentiation and cancer

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dc.contributor.author Mulero, María Carmen
dc.contributor.author Islam, Abul, 1978-
dc.contributor.author Margalef González, Pol, 1985-
dc.contributor.author Pecoraro, Matteo, 1984-
dc.contributor.author Toll Abelló, Agustín
dc.contributor.author Drechsel, Nils Jan Daniel, 1980-
dc.contributor.author Charneco, Cristina
dc.contributor.author Bellora Pereyra, Nicolás
dc.contributor.author Gallardo Hernández, Fernando
dc.contributor.author López Arribillaga, Erika, 1986-
dc.contributor.author Asensio Juan, Elena
dc.contributor.author Rodilla, Verónica
dc.contributor.author González, Jessica
dc.contributor.author Iglesias Coma, Mar
dc.contributor.author Albà Soler, Mar
dc.contributor.author Di Croce, Luciano
dc.contributor.author Villà i Freixa, Jordi
dc.contributor.author López Bigas, Núria
dc.contributor.author Keyes, William M., 1973-
dc.contributor.author Bigas Salvans, Anna
dc.contributor.author Espinosa Blay, Lluís
dc.date.accessioned 2015-11-25T19:43:30Z
dc.date.available 2015-11-25T19:43:30Z
dc.date.issued 2013
dc.identifier.citation Mulero MC, Ferres-Marco D, Islam A, Margalef P, Pecoraro M, Toll A et al. Chromatin-bound IκB-alpha regulates a subset of polycomb target genes in differentiation and cancer. Cancer Cell. 2013; 24(2): 151-166. DOI 10.1016/j.ccr.2013.06.003
dc.identifier.issn 1535-6108
dc.identifier.uri http://hdl.handle.net/10230/25227
dc.description.abstract IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of HOX and IRX genes. Chromatin-bound IκBα modulates Polycomb recruitment and imparts their competence to be activated by TNF-alpha. Mutations in the Drosophila IκBα gene cactus enhance the homeotic phenotype of Polycomb mutants, which is not counteracted by mutations in dorsal/NF-κB. Oncogenic transformation of keratinocytes results in cytoplasmic IκBα translocation associated with a massive activation of Hox. Accumulation of cytoplasmic IκBα was found in squamous cell carcinoma (SCC) associated with IKK activation and HOX upregulation.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof Cancer Cell. 2013; 24(2): 151-166
dc.rights © Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.ccr.2013.06.003 that appeared in the journal Cancer Cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-license
dc.subject.other Cèl·lules
dc.subject.other Pell
dc.subject.other Tumors
dc.title Chromatin-bound IκB-alpha regulates a subset of polycomb target genes in differentiation and cancer
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.ccr.2013.06.003
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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