Chromatin-bound IκB-alpha regulates a subset of polycomb target genes in differentiation and cancer

Mulero, María Carmen; Islam, Abul, 1978-; Margalef González, Pol, 1985-; Pecoraro, Matteo, 1984-; Toll Abelló, Agustín; Drechsel, Nils Jan Daniel, 1980-; Charneco, Cristina; Bellora Pereyra, Nicolás; Gallardo Hernández, Fernando; López Arribillaga, Erika, 1986-; Asensio Juan, Elena; Rodilla, Verónica; González, Jessica; Iglesias Coma, Mar; Albà Soler, Mar; Di Croce, Luciano; Villà i Freixa, Jordi; López Bigas, Núria; Keyes, William M., 1973-; Bigas Salvans, Anna; Espinosa Blay, Lluís

Chromatin-bound IκB-alpha regulates a subset of polycomb target genes in differentiation and cancer

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dc.contributor.author Mulero, María Carmenca
dc.contributor.author Islam, Abul, 1978-ca
dc.contributor.author Margalef González, Pol, 1985-ca
dc.contributor.author Pecoraro, Matteo, 1984-ca
dc.contributor.author Toll Abelló, Agustínca
dc.contributor.author Drechsel, Nils Jan Daniel, 1980-ca
dc.contributor.author Charneco, Cristinaca
dc.contributor.author Bellora Pereyra, Nicolásca
dc.contributor.author Gallardo Hernández, Fernandoca
dc.contributor.author López Arribillaga, Erika, 1986-ca
dc.contributor.author Asensio Juan, Elenaca
dc.contributor.author Rodilla, Verónicaca
dc.contributor.author González, Jessicaca
dc.contributor.author Iglesias Coma, Marca
dc.contributor.author Albà Soler, Marca
dc.contributor.author Di Croce, Lucianoca
dc.contributor.author Villà i Freixa, Jordica
dc.contributor.author López Bigas, Núriaca
dc.contributor.author Keyes, William M., 1973-ca
dc.contributor.author Bigas Salvans, Annaca
dc.contributor.author Espinosa Blay, Lluísca
dc.date.accessioned 2015-11-25T19:43:30Z
dc.date.available 2015-11-25T19:43:30Z
dc.date.issued 2013
dc.description.abstract IκB proteins are the primary inhibitors of NF-κB. Here, we demonstrate that sumoylated and phosphorylated IκBα accumulates in the nucleus of keratinocytes and interacts with histones H2A and H4 at the regulatory region of HOX and IRX genes. Chromatin-bound IκBα modulates Polycomb recruitment and imparts their competence to be activated by TNF-alpha. Mutations in the Drosophila IκBα gene cactus enhance the homeotic phenotype of Polycomb mutants, which is not counteracted by mutations in dorsal/NF-κB. Oncogenic transformation of keratinocytes results in cytoplasmic IκBα translocation associated with a massive activation of Hox. Accumulation of cytoplasmic IκBα was found in squamous cell carcinoma (SCC) associated with IKK activation and HOX upregulation.ca
dc.format.mimetype application/pdfca
dc.identifier.citation Mulero MC, Ferres-Marco D, Islam A, Margalef P, Pecoraro M, Toll A et al. Chromatin-bound IκB-alpha regulates a subset of polycomb target genes in differentiation and cancer. Cancer Cell. 2013; 24(2): 151-166. DOI 10.1016/j.ccr.2013.06.003ca
dc.identifier.doi http://dx.doi.org/10.1016/j.ccr.2013.06.003
dc.identifier.issn 1535-6108
dc.identifier.uri http://hdl.handle.net/10230/25227
dc.language.iso engca
dc.publisher Elsevierca
dc.relation.ispartof Cancer Cell. 2013; 24(2): 151-166
dc.rights © Elsevier This is the published version of an article http://dx.doi.org/10.1016/j.ccr.2013.06.003 that appeared in the journal Cancer Cell. It is published in an Open Archive under an Elsevier user license. Details of this licence are available here: http://www.elsevier.com/about/open-access/open-access-policies/oa-license-policy/elsevier-user-licenseca
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.subject.other Cèl·lules
dc.subject.other Pell
dc.subject.other Tumors
dc.title Chromatin-bound IκB-alpha regulates a subset of polycomb target genes in differentiation and cancerca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

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