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Beyond the whole-genome duplication: phylogenetic evidence for an ancient interspecies hybridization in the Baker's yeast lineage

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dc.contributor.author Marcet Houben, Marina
dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
dc.date.accessioned 2015-11-18T18:39:11Z
dc.date.available 2015-11-18T18:39:11Z
dc.date.issued 2015
dc.identifier.citation Marcet-Houben M, Gabaldón T. Beyond the whole-genome duplication: phylogenetic evidence for an ancient interspecies hybridization in the Baker's yeast lineage. PLoS biology. 2015;13(8):e1002220. DOI: 10.1371/journal.pbio.1002220
dc.identifier.issn 1544-9173
dc.identifier.uri http://hdl.handle.net/10230/25143
dc.description.abstract Whole-genome duplications have shaped the genomes of several vertebrate, plant, and fungal lineages. Earlier studies have focused on establishing when these events occurred and on elucidating their functional and evolutionary consequences, but we still lack sufficient understanding of how genome duplications first originated. We used phylogenomics to study the ancient genome duplication occurred in the yeast Saccharomyces cerevisiae lineage and found compelling evidence for the existence of a contemporaneous interspecies hybridization. We propose that the genome doubling was a direct consequence of this hybridization and that it served to provide stability to the recently formed allopolyploid. This scenario provides a mechanism for the origin of this ancient duplication and the lineage that originated from it and brings a new perspective to the interpretation of the origin and consequences of whole-genome duplications.
dc.description.sponsorship TG group research is funded in part by a grant from the Spanish ministry of Economy and Competitiveness (BIO2012-37161), which includes FEDER structural funds, a grant from the Qatar National Research Fund (NPRP 5-298-3-086), and a grant from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013) / ERC (Grant Agreement n. ERC-2012-StG-310325). The funders had no role in study/ndesign, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS biology. 2015;13(8):e1002220
dc.rights © 2015 Marcet-Houben, Gabaldón. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Saccharomyces cerevisiae -- Metabolisme
dc.subject.other Genomes
dc.title Beyond the whole-genome duplication: phylogenetic evidence for an ancient interspecies hybridization in the Baker's yeast lineage
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pbio.1002220
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/310325
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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