Beyond the whole-genome duplication: phylogenetic evidence for an ancient interspecies hybridization in the Baker's yeast lineage
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- dc.contributor.author Marcet Houben, Marinaca
- dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-ca
- dc.date.accessioned 2015-11-18T18:39:11Z
- dc.date.available 2015-11-18T18:39:11Z
- dc.date.issued 2015
- dc.description.abstract Whole-genome duplications have shaped the genomes of several vertebrate, plant, and fungal lineages. Earlier studies have focused on establishing when these events occurred and on elucidating their functional and evolutionary consequences, but we still lack sufficient understanding of how genome duplications first originated. We used phylogenomics to study the ancient genome duplication occurred in the yeast Saccharomyces cerevisiae lineage and found compelling evidence for the existence of a contemporaneous interspecies hybridization. We propose that the genome doubling was a direct consequence of this hybridization and that it served to provide stability to the recently formed allopolyploid. This scenario provides a mechanism for the origin of this ancient duplication and the lineage that originated from it and brings a new perspective to the interpretation of the origin and consequences of whole-genome duplications.en
- dc.description.sponsorship TG group research is funded in part by a grant from the Spanish ministry of Economy and Competitiveness (BIO2012-37161), which includes FEDER structural funds, a grant from the Qatar National Research Fund (NPRP 5-298-3-086), and a grant from the European Research Council under the European Union's Seventh Framework Programme (FP/2007-2013) / ERC (Grant Agreement n. ERC-2012-StG-310325). The funders had no role in study/ndesign, data collection and analysis, decision to publish, or preparation of the manuscript.
- dc.format.mimetype application/pdfca
- dc.identifier.citation Marcet-Houben M, Gabaldón T. Beyond the whole-genome duplication: phylogenetic evidence for an ancient interspecies hybridization in the Baker's yeast lineage. PLoS biology. 2015;13(8):e1002220. DOI: 10.1371/journal.pbio.1002220ca
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pbio.1002220
- dc.identifier.issn 1544-9173
- dc.identifier.uri http://hdl.handle.net/10230/25143
- dc.language.iso engca
- dc.publisher Public Library of Science (PLoS)ca
- dc.relation.ispartof PLoS biology. 2015;13(8):e1002220
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/310325
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/BIO2012-37161
- dc.rights © 2015 Marcet-Houben, Gabaldón. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.other Saccharomyces cerevisiae -- Metabolisme
- dc.subject.other Genomes
- dc.title Beyond the whole-genome duplication: phylogenetic evidence for an ancient interspecies hybridization in the Baker's yeast lineageen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca