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A shift in anterior–posterior positional information underlies the fin-to-limb evolution

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dc.contributor.author Onimaru, Koh
dc.contributor.author Kuraku, Shigehiro
dc.contributor.author Takagi, Wataru
dc.contributor.author Hyodo, Susumu
dc.contributor.author Sharpe, James
dc.contributor.author Tanaka, Mikiko
dc.date.accessioned 2015-11-10T14:45:18Z
dc.date.available 2015-11-10T14:45:18Z
dc.date.issued 2015
dc.identifier.citation Onimaru K, Kuraku S, Takagi W, Hyodo S, Sharpe J, Tanaka M. A shift in anterior–posterior positional information underlies the fin-to-limb evolution. eLife. 2015;4:e07048. DOI: 10.7554/eLife.07048
dc.identifier.issn 2050-084X
dc.identifier.uri http://hdl.handle.net/10230/25036
dc.description.abstract The pectoral fins of ancestral fishes had multiple proximal elements connected to their pectoral girdles. During the fin-to-limb transition, anterior proximal elements were lost and only the most posterior one remained as the humerus. Thus, we hypothesised that an evolutionary alteration occurred in the anterior–posterior (AP) patterning system of limb buds. In this study, we examined the pectoral fin development of catshark (Scyliorhinus canicula) and revealed that the AP positional values in fin buds are shifted more posteriorly than mouse limb buds. Furthermore, examination of Gli3 function and regulation shows that catshark fins lack a specific AP patterning mechanism, which restricts its expression to an anterior domain in tetrapods. Finally, experimental perturbation of AP patterning in catshark fin buds results in an expansion of posterior values and loss of anterior skeletal elements. Together, these results suggest that a key genetic event of the fin-to-limb transformation was alteration of the AP patterning network.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher eLife
dc.relation.ispartof eLife. 2015;4:e07048
dc.rights Copyright Onimaru et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Genètica del desenvolupament
dc.subject.other Biologia del desenvolupament
dc.title A shift in anterior–posterior positional information underlies the fin-to-limb evolution
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.7554/eLife.07048
dc.subject.keyword C. milii
dc.subject.keyword Chicken
dc.subject.keyword Fin-to-limb transition
dc.subject.keyword Mouse
dc.subject.keyword S. canicula
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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