A shift in anterior–posterior positional information underlies the fin-to-limb evolution
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- dc.contributor.author Onimaru, Kohca
- dc.contributor.author Kuraku, Shigehiroca
- dc.contributor.author Takagi, Wataruca
- dc.contributor.author Hyodo, Susumuca
- dc.contributor.author Sharpe, Jamesca
- dc.contributor.author Tanaka, Mikikoca
- dc.date.accessioned 2015-11-10T14:45:18Z
- dc.date.available 2015-11-10T14:45:18Z
- dc.date.issued 2015
- dc.description.abstract The pectoral fins of ancestral fishes had multiple proximal elements connected to their pectoral girdles. During the fin-to-limb transition, anterior proximal elements were lost and only the most posterior one remained as the humerus. Thus, we hypothesised that an evolutionary alteration occurred in the anterior–posterior (AP) patterning system of limb buds. In this study, we examined the pectoral fin development of catshark (Scyliorhinus canicula) and revealed that the AP positional values in fin buds are shifted more posteriorly than mouse limb buds. Furthermore, examination of Gli3 function and regulation shows that catshark fins lack a specific AP patterning mechanism, which restricts its expression to an anterior domain in tetrapods. Finally, experimental perturbation of AP patterning in catshark fin buds results in an expansion of posterior values and loss of anterior skeletal elements. Together, these results suggest that a key genetic event of the fin-to-limb transformation was alteration of the AP patterning network.ca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Onimaru K, Kuraku S, Takagi W, Hyodo S, Sharpe J, Tanaka M. A shift in anterior–posterior positional information underlies the fin-to-limb evolution. eLife. 2015;4:e07048. DOI: 10.7554/eLife.07048ca
- dc.identifier.doi http://dx.doi.org/10.7554/eLife.07048
- dc.identifier.issn 2050-084X
- dc.identifier.uri http://hdl.handle.net/10230/25036
- dc.language.iso engca
- dc.publisher eLifeca
- dc.relation.ispartof eLife. 2015;4:e07048
- dc.rights Copyright Onimaru et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.keyword C. milii
- dc.subject.keyword Chicken
- dc.subject.keyword Fin-to-limb transition
- dc.subject.keyword Mouse
- dc.subject.keyword S. canicula
- dc.subject.other Genètica del desenvolupamentca
- dc.subject.other Biologia del desenvolupamentca
- dc.title A shift in anterior–posterior positional information underlies the fin-to-limb evolutionca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionca