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Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy.

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dc.contributor.author Cuadrado-Godia, Elisa
dc.contributor.author Regueiro, Ander
dc.contributor.author Núñez, Julio
dc.contributor.author Díaz-Ricard, Maribel
dc.contributor.author Novella, Susana
dc.contributor.author Oliveras, Anna
dc.contributor.author Valverde, M. A. (Miguel Ángel), 1963-
dc.contributor.author Marrugat de la Iglesia, Jaume
dc.contributor.author Ois Santiago, Angel Javier
dc.contributor.author Giralt-Steinhauer, Eva
dc.contributor.author Sanchís, Juan
dc.contributor.author Escolar, Ginès
dc.contributor.author Hermenegildo, Carlos
dc.contributor.author Heras, Magda
dc.contributor.author Roquer, Jaume
dc.date.accessioned 2015-10-08T07:50:10Z
dc.date.available 2015-10-08T07:50:10Z
dc.date.issued 2015
dc.identifier.citation Cuadrado-Godia E, Regueiro A, Núñez J, Díaz-Ricard M, Novella S, Oliveras A. Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy. PLoS One. 2015 Sep 2;10(9):e0132415. DOI: 10.1371/journal.pone.0132415.
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/24821
dc.description.abstract INTRODUCTION: The aim of this study was to determine prognostic factors for the risk of new vascular events during the first 6 months after acute myocardial infarction (AMI) or atherothrombotic stroke (AS). We were interested in the prognostic role of endothelial progenitor cells (EPC) and circulating endothelial cells (CEC). METHODS: Between February 2009 and July 2012, 100 AMI and 50 AS patients were consecutively studied in three Spanish centres. Patients with previously documented coronary artery disease or ischemic strokes were excluded. Samples were collected within 24h of onset of symptoms. EPC and CEC were studied using flow cytometry and categorized by quartiles. Patients were followed for up to 6 months. NVE was defined as new acute coronary syndrome, transient ischemic attack (TIA), stroke, or any hospitalization or death from cardiovascular causes. The variables included in the analysis included: vascular risk factors, carotid intima-media thickness (IMT), atherosclerotic burden and basal EPC and CEC count. Multivariate survival analysis was performed using Cox regression analysis. RESULTS: During follow-up, 19 patients (12.66%) had a new vascular event (5 strokes; 3 TIAs; 4 AMI; 6 hospitalizations; 1 death). Vascular events were associated with age (P = 0.039), carotid IMT≥0.9 (P = 0.044), and EPC count (P = 0.041) in the univariate analysis. Multivariate Cox regression analysis showed an independent association with EPC in the lowest quartile (HR: 10.33, 95%CI (1.22-87.34), P = 0.032] and IMT≥0.9 [HR: 4.12, 95%CI (1.21-13.95), P = 0.023]. CONCLUSIONS: Basal EPC and IMT≥0.9 can predict future vascular events in patients with AMI and AS, but CEC count does not affect cardiovascular risk
dc.description.sponsorship This study was supported in part bySpain’s Ministry of Health (Ministerio de Sanidad y Consumo, FONDO DE INVESTIGACIÓN SANITARIA, Instituto de Salud Carlos III. Grant number: PI080459, RED DE INVESTIGACIÓN/nCARDIOVASCULAR (RIC RD12/0042/0010, RIC RD12/0042/0052, RD12/0042/0020).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartof PLoS One. 2015 Sep 2;10(9):e0132415
dc.rights © 2015 Cuadrado-Godia et al. This is an open access article distributed under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are/ncredited
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Infart de miocardi -- Factors de risc
dc.title Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0132415
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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