Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy.

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  • dc.contributor.author Cuadrado-Godia, Elisaca
  • dc.contributor.author Regueiro, Anderca
  • dc.contributor.author Núñez, Julioca
  • dc.contributor.author Díaz-Ricard, Maribelca
  • dc.contributor.author Novella, Susanaca
  • dc.contributor.author Oliveras, Annaca
  • dc.contributor.author Valverde, M. A. (Miguel Ángel), 1963-ca
  • dc.contributor.author Marrugat de la Iglesia, Jaumeca
  • dc.contributor.author Ois Santiago, Angel Javierca
  • dc.contributor.author Giralt-Steinhauer, Evaca
  • dc.contributor.author Sanchís, Juanca
  • dc.contributor.author Escolar, Ginèsca
  • dc.contributor.author Hermenegildo, Carlosca
  • dc.contributor.author Heras, Magdaca
  • dc.contributor.author Roquer, Jaumeca
  • dc.date.accessioned 2015-10-08T07:50:10Z
  • dc.date.available 2015-10-08T07:50:10Z
  • dc.date.issued 2015
  • dc.description.abstract INTRODUCTION: The aim of this study was to determine prognostic factors for the risk of new vascular events during the first 6 months after acute myocardial infarction (AMI) or atherothrombotic stroke (AS). We were interested in the prognostic role of endothelial progenitor cells (EPC) and circulating endothelial cells (CEC). METHODS: Between February 2009 and July 2012, 100 AMI and 50 AS patients were consecutively studied in three Spanish centres. Patients with previously documented coronary artery disease or ischemic strokes were excluded. Samples were collected within 24h of onset of symptoms. EPC and CEC were studied using flow cytometry and categorized by quartiles. Patients were followed for up to 6 months. NVE was defined as new acute coronary syndrome, transient ischemic attack (TIA), stroke, or any hospitalization or death from cardiovascular causes. The variables included in the analysis included: vascular risk factors, carotid intima-media thickness (IMT), atherosclerotic burden and basal EPC and CEC count. Multivariate survival analysis was performed using Cox regression analysis. RESULTS: During follow-up, 19 patients (12.66%) had a new vascular event (5 strokes; 3 TIAs; 4 AMI; 6 hospitalizations; 1 death). Vascular events were associated with age (P = 0.039), carotid IMT≥0.9 (P = 0.044), and EPC count (P = 0.041) in the univariate analysis. Multivariate Cox regression analysis showed an independent association with EPC in the lowest quartile (HR: 10.33, 95%CI (1.22-87.34), P = 0.032] and IMT≥0.9 [HR: 4.12, 95%CI (1.21-13.95), P = 0.023]. CONCLUSIONS: Basal EPC and IMT≥0.9 can predict future vascular events in patients with AMI and AS, but CEC count does not affect cardiovascular riskca
  • dc.description.sponsorship This study was supported in part bySpain’s Ministry of Health (Ministerio de Sanidad y Consumo, FONDO DE INVESTIGACIÓN SANITARIA, Instituto de Salud Carlos III. Grant number: PI080459, RED DE INVESTIGACIÓN/nCARDIOVASCULAR (RIC RD12/0042/0010, RIC RD12/0042/0052, RD12/0042/0020).
  • dc.format.mimetype application/pdfca
  • dc.identifier.citation Cuadrado-Godia E, Regueiro A, Núñez J, Díaz-Ricard M, Novella S, Oliveras A. Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy. PLoS One. 2015 Sep 2;10(9):e0132415. DOI: 10.1371/journal.pone.0132415.ca
  • dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0132415
  • dc.identifier.issn 1932-6203
  • dc.identifier.uri http://hdl.handle.net/10230/24821
  • dc.language.iso engca
  • dc.publisher Public Library of Scienceca
  • dc.relation.ispartof PLoS One. 2015 Sep 2;10(9):e0132415
  • dc.rights © 2015 Cuadrado-Godia et al. This is an open access article distributed under the terms of the http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are/ncreditedca
  • dc.rights.accessRights info:eu-repo/semantics/openAccessca
  • dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
  • dc.subject.other Infart de miocardi -- Factors de riscca
  • dc.title Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy.ca
  • dc.type info:eu-repo/semantics/articleca
  • dc.type.version info:eu-repo/semantics/publishedVersionca

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Articles (Hospital del Mar Research Institute)
Articles (Departament de Medicina i Ciències de la Vida)