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Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes.

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dc.contributor.author Casas, Lidia
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Tischer, Christina
dc.contributor.author Gehring, Ulrike
dc.contributor.author Wickman, Magnus
dc.contributor.author García Esteban, Raquel
dc.contributor.author Lehmann, Irina
dc.contributor.author Kull, Inger
dc.contributor.author Reich, Andreas
dc.contributor.author Lau, Susanne
dc.contributor.author Wijga, Alet
dc.contributor.author Antó i Boqué, Josep Maria
dc.contributor.author Nawrot, Tim S.
dc.contributor.author Heinrich, Joachim
dc.contributor.author Keil, Thomas
dc.contributor.author Torrent Quetglas, Maties
dc.date.accessioned 2015-06-29T11:37:26Z
dc.date.available 2016-07-31T02:00:04Z
dc.date.issued 2015
dc.identifier.citation Casas L, Sunyer J, Tischer C, Gehring U, Wickman M, Garcia-Esteban R. et al. Allergy. 2015 Jul;70(7):820-7. doi: 10.1111/all.12626
dc.identifier.issn 0105-4538
dc.identifier.uri http://hdl.handle.net/10230/24572
dc.description.abstract BACKGROUND: Exposure to indoor allergens during early life may play a role in the development of the immune system and inception of asthma. OBJECTIVE: To describe the house dust mite (HDM) allergen concentrations in bedroom dust during early life and to evaluate its associations with HDM sensitization, wheezing, and asthma, from birth to school age, in 5 geographically spread European birth cohorts. METHODS: We included 4334 children from INMA-Menorca (Spain), BAMSE (Sweden), LISAplus and MAS (Germany), and PIAMA-NHS (the Netherlands). Dust samples were collected from bedrooms during early life and analyzed for Dermatophagoides pteronyssinus (Der p1) and Dermatophagoides farinae (Der f1). HDM concentrations were divided into four categories. Sensitization was determined by specific IgE. Wheezing and asthma information up to 8/10 years was collected through questionnaires. We performed mixed-effects logistic regression models and expressed associations as odds ratios with 95% confidence intervals. RESULTS: House dust mite concentrations varied across cohorts. Mean allergen concentrations were highest in INMA-Menorca (geometric mean (GM) Der p1 = 3.3 μg/g) and LISAplus (GM Der f1 = 2.1 μg/g) and lowest in BAMSE (GM Der p1 = 0.1 μg/g, Der f1 = 0.3 μg/g). Moderate and high HDM concentrations were significantly (P-values < 0.05) associated with 50-90% higher prevalence of HDM sensitization. No significant associations were observed with respiratory outcomes./nCONCLUSION: Our study based on geographically spread regions, a large sample size, and a wide range of allergen concentration shows that HDM allergen concentrations vary across regions and that exposure during early life plays a role in the development of allergic sensitization but not in the development of respiratory outcomes.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Wiley
dc.rights © Wiley-Blackwell. The definitive version is available online at: http://dx.doi.org/10.1111/all.12626
dc.subject.other Malalties al·lèrgiques
dc.subject.other Pediatria
dc.title Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1111/all.12626
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion


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