Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes.

Casas, Lidia; Sunyer Deu, Jordi; Tischer, Christina; Gehring, Ulrike; Wickman, Magnus; García Esteban, Raquel; Lehmann, Irina; Kull, Inger; Reich, Andreas; Lau, Susanne; Wijga, Alet; Antó i Boqué, Josep Maria; Nawrot, Tim S.; Heinrich, Joachim; Keil, Thomas; Torrent Quetglas, Maties

Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes.

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dc.contributor.author Casas, Lidiaca
dc.contributor.author Sunyer Deu, Jordica
dc.contributor.author Tischer, Christinaca
dc.contributor.author Gehring, Ulrikeca
dc.contributor.author Wickman, Magnusca
dc.contributor.author García Esteban, Raquelca
dc.contributor.author Lehmann, Irinaca
dc.contributor.author Kull, Ingerca
dc.contributor.author Reich, Andreasca
dc.contributor.author Lau, Susanneca
dc.contributor.author Wijga, Aletca
dc.contributor.author Antó i Boqué, Josep Mariaca
dc.contributor.author Nawrot, Tim S.ca
dc.contributor.author Heinrich, Joachimca
dc.contributor.author Keil, Thomasca
dc.contributor.author Torrent Quetglas, Matiesca
dc.date.accessioned 2015-06-29T11:37:26Z
dc.date.available 2016-07-31T02:00:04Z
dc.date.issued 2015
dc.description.abstract BACKGROUND: Exposure to indoor allergens during early life may play a role in the development of the immune system and inception of asthma. OBJECTIVE: To describe the house dust mite (HDM) allergen concentrations in bedroom dust during early life and to evaluate its associations with HDM sensitization, wheezing, and asthma, from birth to school age, in 5 geographically spread European birth cohorts. METHODS: We included 4334 children from INMA-Menorca (Spain), BAMSE (Sweden), LISAplus and MAS (Germany), and PIAMA-NHS (the Netherlands). Dust samples were collected from bedrooms during early life and analyzed for Dermatophagoides pteronyssinus (Der p1) and Dermatophagoides farinae (Der f1). HDM concentrations were divided into four categories. Sensitization was determined by specific IgE. Wheezing and asthma information up to 8/10 years was collected through questionnaires. We performed mixed-effects logistic regression models and expressed associations as odds ratios with 95% confidence intervals. RESULTS: House dust mite concentrations varied across cohorts. Mean allergen concentrations were highest in INMA-Menorca (geometric mean (GM) Der p1 = 3.3 μg/g) and LISAplus (GM Der f1 = 2.1 μg/g) and lowest in BAMSE (GM Der p1 = 0.1 μg/g, Der f1 = 0.3 μg/g). Moderate and high HDM concentrations were significantly (P-values < 0.05) associated with 50-90% higher prevalence of HDM sensitization. No significant associations were observed with respiratory outcomes./nCONCLUSION: Our study based on geographically spread regions, a large sample size, and a wide range of allergen concentration shows that HDM allergen concentrations vary across regions and that exposure during early life plays a role in the development of allergic sensitization but not in the development of respiratory outcomes.ca
dc.format.mimetype application/pdfca
dc.identifier.citation Casas L, Sunyer J, Tischer C, Gehring U, Wickman M, Garcia-Esteban R. et al. Allergy. 2015 Jul;70(7):820-7. doi: 10.1111/all.12626ca
dc.identifier.doi http://dx.doi.org/10.1111/all.12626
dc.identifier.issn 0105-4538
dc.identifier.uri http://hdl.handle.net/10230/24572
dc.language.iso engca
dc.publisher Wileyca
dc.relation.ispartof Allergy. 2015 Jul;70(7):820-7.
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.subject.other Malalties al·lèrgiquesca
dc.subject.other Pediatriaca
dc.title Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes.ca
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/acceptedVersionca

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