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The neuroanatomical basis of panic disorder and social phobia in schizophrenia: a voxel based morphometric study.

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dc.contributor.author Picado, Marisol
dc.contributor.author Carmona, Susanna
dc.contributor.author Hoekzema, Elseline
dc.contributor.author Pailhez, Guillem
dc.contributor.author Berge Baquero, Daniel
dc.contributor.author Mané Santacana, Anna
dc.contributor.author Fauquet, Jordi
dc.contributor.author Hilferty, Joseph
dc.contributor.author Moreno, Ana
dc.contributor.author Cortizo Vidal, Romina
dc.contributor.author Vilarroya, Óscar
dc.contributor.author Bulbena Vilarrasa, Antonio
dc.date.accessioned 2015-05-22T09:05:57Z
dc.date.available 2015-05-22T09:05:57Z
dc.date.issued 2015
dc.identifier.citation Picado M, Carmona S, Hoekzema E, Pailhez G, Bergé D, Mané A. The neuroanatomical basis of panic disorder and social phobia in schizophrenia: a voxel based morphometric study. PLoS One. 2015 Mar 16;10(3):e0119847. doi: 10.1371/journal.pone.0119847. eCollection 2015.
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/23620
dc.description.abstract OBJECTIVE: It is known that there is a high prevalence of certain anxiety disorders among schizophrenic patients, especially panic disorder and social phobia. However, the neural underpinnings of the comorbidity of such anxiety disorders and schizophrenia remain unclear. Our study aims to determine the neuroanatomical basis of the co-occurrence of schizophrenia with panic disorder and social phobia. METHODS: Voxel-based morphometry was used in order to examine brain structure and to measure between-group differences, comparing magnetic resonance images of 20 anxious patients, 20 schizophrenic patients, 20 schizophrenic patients with comorbid anxiety, and 20 healthy control subjects. RESULTS: Compared to the schizophrenic patients, we observed smaller grey-matter volume (GMV) decreases in the dorsolateral prefrontal cortex and precentral gyrus in the schizophrenic-anxiety group. Additionally, the schizophrenic group showed significantly reduced GMV in the dorsolateral prefrontal cortex, precentral gyrus, orbitofrontal cortex, temporal gyrus and angular/inferior parietal gyrus when compared to the control group. CONCLUSIONS: Our findings suggest that the comorbidity of schizophrenia with panic disorder and social phobia might be characterized by specific neuroanatomical and clinical alterations that may be related to maladaptive emotion regulation related to anxiety. Even thought our findings need to be replicated, our study suggests that the identification of neural abnormalities involved in anxiety, schizophrenia and schizophrenia-anxiety may lead to an improved diagnosis and management of these conditions.
dc.description.sponsorship Funding was provided by the Fondo deInvestigación Sanitaria (Pi052381). MP is supportedby a FI grant of the Agencia de Gestió d’AjutsUniversitaris i de Recerca
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartof PLoS One. 2015 Mar 16;10(3):e0119847
dc.rights © 2015 Picado et al. This is an openaccess article distributed under the terms of the http://creativecommons.org/licenses/by/4.0/, which permitsunrestricted use, distribution, and reproduction in anymedium, provided the original author and source arecredited.
dc.rights.uri http://creativecommons.org/licenses/by/4.0/
dc.subject.other Malalties mentals
dc.subject.other Esquizofrènia
dc.subject.other Trastorns de pànic
dc.title The neuroanatomical basis of panic disorder and social phobia in schizophrenia: a voxel based morphometric study.
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0119847
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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