The neuroanatomical basis of panic disorder and social phobia in schizophrenia: a voxel based morphometric study.
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- dc.contributor.author Picado, Marisolca
- dc.contributor.author Carmona, Susannaca
- dc.contributor.author Hoekzema, Elselineca
- dc.contributor.author Pailhez, Guillemca
- dc.contributor.author Berge Baquero, Danielca
- dc.contributor.author Mané Santacana, Annaca
- dc.contributor.author Fauquet, Jordica
- dc.contributor.author Hilferty, Josephca
- dc.contributor.author Moreno, Anaca
- dc.contributor.author Cortizo Vidal, Rominaca
- dc.contributor.author Vilarroya, Óscarca
- dc.contributor.author Bulbena Vilarrasa, Antonioca
- dc.date.accessioned 2015-05-22T09:05:57Z
- dc.date.available 2015-05-22T09:05:57Z
- dc.date.issued 2015
- dc.description.abstract OBJECTIVE: It is known that there is a high prevalence of certain anxiety disorders among schizophrenic patients, especially panic disorder and social phobia. However, the neural underpinnings of the comorbidity of such anxiety disorders and schizophrenia remain unclear. Our study aims to determine the neuroanatomical basis of the co-occurrence of schizophrenia with panic disorder and social phobia. METHODS: Voxel-based morphometry was used in order to examine brain structure and to measure between-group differences, comparing magnetic resonance images of 20 anxious patients, 20 schizophrenic patients, 20 schizophrenic patients with comorbid anxiety, and 20 healthy control subjects. RESULTS: Compared to the schizophrenic patients, we observed smaller grey-matter volume (GMV) decreases in the dorsolateral prefrontal cortex and precentral gyrus in the schizophrenic-anxiety group. Additionally, the schizophrenic group showed significantly reduced GMV in the dorsolateral prefrontal cortex, precentral gyrus, orbitofrontal cortex, temporal gyrus and angular/inferior parietal gyrus when compared to the control group. CONCLUSIONS: Our findings suggest that the comorbidity of schizophrenia with panic disorder and social phobia might be characterized by specific neuroanatomical and clinical alterations that may be related to maladaptive emotion regulation related to anxiety. Even thought our findings need to be replicated, our study suggests that the identification of neural abnormalities involved in anxiety, schizophrenia and schizophrenia-anxiety may lead to an improved diagnosis and management of these conditions.ca
- dc.description.sponsorship Funding was provided by the Fondo deInvestigación Sanitaria (Pi052381). MP is supportedby a FI grant of the Agencia de Gestió d’AjutsUniversitaris i de Recerca
- dc.format.mimetype application/pdfca
- dc.identifier.citation Picado M, Carmona S, Hoekzema E, Pailhez G, Bergé D, Mané A. The neuroanatomical basis of panic disorder and social phobia in schizophrenia: a voxel based morphometric study. PLoS One. 2015 Mar 16;10(3):e0119847. doi: 10.1371/journal.pone.0119847. eCollection 2015.ca
- dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0119847
- dc.identifier.issn 1932-6203
- dc.identifier.uri http://hdl.handle.net/10230/23620
- dc.language.iso engca
- dc.publisher Public Library of Scienceca
- dc.relation.ispartof PLoS One. 2015 Mar 16;10(3):e0119847
- dc.rights © 2015 Picado et al. This is an openaccess article distributed under the terms of the http://creativecommons.org/licenses/by/4.0/, which permitsunrestricted use, distribution, and reproduction in anymedium, provided the original author and source arecredited.ca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/ca
- dc.subject.other Malalties mentalsca
- dc.subject.other Esquizofrèniaca
- dc.subject.other Trastorns de pànicca
- dc.title The neuroanatomical basis of panic disorder and social phobia in schizophrenia: a voxel based morphometric study.ca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca