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Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition

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dc.contributor.author Morales, Eva
dc.contributor.author Bustamante Pineda, Mariona
dc.contributor.author González Ruiz, Juan Ramón
dc.contributor.author Guxens Junyent, Mònica
dc.contributor.author Torrent Quetglas, Maties
dc.contributor.author Mendez, Michelle A.
dc.contributor.author García Esteban, Raquel
dc.contributor.author Júlvez Calvo, Jordi
dc.contributor.author Forns i Guzman, Joan, 1981-
dc.contributor.author Vrijheid, Martine
dc.contributor.author Molto Puigmarti, Carolina
dc.contributor.author López Sabater, M. Carmen
dc.contributor.author Estivill, Xavier, 1955-
dc.contributor.author Sunyer Deu, Jordi
dc.date.accessioned 2015-04-29T09:17:18Z
dc.date.available 2015-04-29T09:17:18Z
dc.date.issued 2011
dc.identifier.citation Morales E, Bustamante M, Gonzalez JR, Guxens M, Torrent M, Mendez M et al. Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition. PLoS ONE. 2011;6(2):e17181. DOI: 10.1371/journal.pone.0017181
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/23494
dc.description.abstract Introduction: Breastfeeding effects on cognition are attributed to long-chain polyunsaturated fatty acids (LC-PUFAs), but controversy persists. Genetic variation in fatty acid desaturase (FADS) and elongase (ELOVL) enzymes has been overlooked when studying the effects of LC-PUFAs supply on cognition. We aimed to: 1) to determine whether maternal genetic variants in the FADS cluster and ELOVL genes contribute to differences in LC-PUFA levels in colostrum; 2) to analyze whether these maternal variants are related to child cognition; and 3) to assess whether children's variants modify breastfeeding effects on cognition. Methods: Data come from two population-based birth cohorts (n = 400 mother-child pairs from INMA-Sabadell; and n = 340 children from INMA-Menorca). LC-PUFAs were measured in 270 colostrum samples from INMA-Sabadell. Tag SNPs were genotyped both in mothers and children (13 in the FADS cluster, 6 in ELOVL2, and 7 in ELOVL5). Child cognition was assessed at 14 mo and 4 y using the Bayley Scales of Infant Development and the McCarthy Scales of Children's Abilities, respectively. Results: Children of mothers carrying genetic variants associated with lower FADS1 activity (regulating AA and EPA synthesis), higher FADS2 activity (regulating DHA synthesis), and with higher EPA/AA and DHA/AA ratios in colostrum showed a significant advantage in cognition at 14 mo (3.5 to 5.3 points). Not being breastfed conferred an 8- to 9-point disadvantage in cognition among children GG homozygote for rs174468 (low FADS1 activity) but not among those with the A allele. Moreover, not being breastfed resulted in a disadvantage in cognition (5 to 8 points) among children CC homozygote for rs2397142 (low ELOVL5 activity), but not among those carrying the G allele. Conclusion: Genetically determined maternal supplies of LC-PUFAs during pregnancy and lactation appear to be crucial for child cognition. Breastfeeding effects on cognition are modified by child genetic variation in fatty acid desaturase and elongase enzymes.
dc.description.sponsorship This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041), Spanish Ministry of Health (FIS-PI041436, FIS-PI081151, 97/0588, 00/0021-2, PI061756 and PS0901958), Generalitat de Catalunya-CIRIT 1999SGR 00241, Beca de la IV convocatoria de Ayudas a la Investigación en Enfermedades Neurodegenerativas de La Caixa, EC Contract No. QLK4-CT-2000-00263, Fundación Roger Torné, and Fundació La Marató de TV3 (Project No. 090430). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS ONE. 2011;6(2):e17181
dc.rights © 2011 Morales et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits/nunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.subject.other Àcids grassos insaturats
dc.subject.other Trastorns de la cognició
dc.subject.other Infants -- Desenvolupament
dc.title Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0017181
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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