Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition

Morales, Eva; Bustamante Pineda, Mariona; González Ruiz, Juan Ramón; Guxens Junyent, Mònica; Torrent Quetglas, Maties; Mendez, Michelle A.; García Esteban, Raquel; Júlvez Calvo, Jordi; Forns i Guzman, Joan, 1981-; Vrijheid, Martine; Molto Puigmarti, Carolina; López Sabater, M. Carmen; Estivill, Xavier, 1955-; Sunyer Deu, Jordi

Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition

Mostra el registre complet Registre parcial de l'ítem

dc.contributor.author Morales, Evaca
dc.contributor.author Bustamante Pineda, Marionaca
dc.contributor.author González Ruiz, Juan Ramónca
dc.contributor.author Guxens Junyent, Mònicaca
dc.contributor.author Torrent Quetglas, Matiesca
dc.contributor.author Mendez, Michelle A.ca
dc.contributor.author García Esteban, Raquelca
dc.contributor.author Júlvez Calvo, Jordica
dc.contributor.author Forns i Guzman, Joan, 1981-ca
dc.contributor.author Vrijheid, Martineca
dc.contributor.author Molto Puigmarti, Carolinaca
dc.contributor.author López Sabater, M. Carmenca
dc.contributor.author Estivill, Xavier, 1955-ca
dc.contributor.author Sunyer Deu, Jordica
dc.date.accessioned 2015-04-29T09:17:18Z
dc.date.available 2015-04-29T09:17:18Z
dc.date.issued 2011ca
dc.description.abstract Introduction: Breastfeeding effects on cognition are attributed to long-chain polyunsaturated fatty acids (LC-PUFAs), but controversy persists. Genetic variation in fatty acid desaturase (FADS) and elongase (ELOVL) enzymes has been overlooked when studying the effects of LC-PUFAs supply on cognition. We aimed to: 1) to determine whether maternal genetic variants in the FADS cluster and ELOVL genes contribute to differences in LC-PUFA levels in colostrum; 2) to analyze whether these maternal variants are related to child cognition; and 3) to assess whether children's variants modify breastfeeding effects on cognition. Methods: Data come from two population-based birth cohorts (n = 400 mother-child pairs from INMA-Sabadell; and n = 340 children from INMA-Menorca). LC-PUFAs were measured in 270 colostrum samples from INMA-Sabadell. Tag SNPs were genotyped both in mothers and children (13 in the FADS cluster, 6 in ELOVL2, and 7 in ELOVL5). Child cognition was assessed at 14 mo and 4 y using the Bayley Scales of Infant Development and the McCarthy Scales of Children's Abilities, respectively. Results: Children of mothers carrying genetic variants associated with lower FADS1 activity (regulating AA and EPA synthesis), higher FADS2 activity (regulating DHA synthesis), and with higher EPA/AA and DHA/AA ratios in colostrum showed a significant advantage in cognition at 14 mo (3.5 to 5.3 points). Not being breastfed conferred an 8- to 9-point disadvantage in cognition among children GG homozygote for rs174468 (low FADS1 activity) but not among those with the A allele. Moreover, not being breastfed resulted in a disadvantage in cognition (5 to 8 points) among children CC homozygote for rs2397142 (low ELOVL5 activity), but not among those carrying the G allele. Conclusion: Genetically determined maternal supplies of LC-PUFAs during pregnancy and lactation appear to be crucial for child cognition. Breastfeeding effects on cognition are modified by child genetic variation in fatty acid desaturase and elongase enzymes.en
dc.description.sponsorship This study was funded by grants from Instituto de Salud Carlos III (Red INMA G03/176, CB06/02/0041), Spanish Ministry of Health (FIS-PI041436, FIS-PI081151, 97/0588, 00/0021-2, PI061756 and PS0901958), Generalitat de Catalunya-CIRIT 1999SGR 00241, Beca de la IV convocatoria de Ayudas a la Investigación en Enfermedades Neurodegenerativas de La Caixa, EC Contract No. QLK4-CT-2000-00263, Fundación Roger Torné, and Fundació La Marató de TV3 (Project No. 090430). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.format.mimetype application/pdfca
dc.identifier.citation Morales E, Bustamante M, Gonzalez JR, Guxens M, Torrent M, Mendez M et al. Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognition. PLoS ONE. 2011;6(2):e17181. DOI: 10.1371/journal.pone.0017181ca
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0017181
dc.identifier.issn 1932-6203ca
dc.identifier.uri http://hdl.handle.net/10230/23494
dc.language.iso engca
dc.publisher Public Library of Science (PLoS)ca
dc.relation.ispartof PLoS ONE. 2011;6(2):e17181
dc.rights © 2011 Morales et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits/nunrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited
dc.rights.accessRights info:eu-repo/semantics/openAccessca
dc.subject.other Àcids grassos insaturatsca
dc.subject.other Trastorns de la cognicióca
dc.subject.other Infants -- Desenvolupamentca
dc.title Genetic variants of the FADS gene cluster and ELOVL gene family, colostrums LC-PUFA levels, breastfeeding, and child cognitionen
dc.type info:eu-repo/semantics/articleca
dc.type.version info:eu-repo/semantics/publishedVersionca

Col·leccions

Articles (Departament de Medicina i Ciències de la Vida)
Articles (Barcelona Institute for Global Health (ISGlobal) – Campus Mar)