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The Human Early-Life Exposome (HELIX): project rationale and design

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dc.contributor.author Vrijheid, Martine
dc.contributor.author Robinson, Oliver
dc.contributor.author Basagaña Flores, Xavier
dc.contributor.author Bustamante Pineda, Mariona
dc.contributor.author Casas Sanahuja, Maribel
dc.contributor.author Estivill, Xavier, 1955-
dc.contributor.author van Gent, Diana
dc.contributor.author González Ruiz, Juan Ramón
dc.contributor.author Júlvez Calvo, Jordi
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Sabidó Aguadé, Eduard, 1981-
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Nieuwenhuijsen, Mark J.
dc.date.accessioned 2015-04-13T07:30:04Z
dc.date.available 2015-04-13T07:30:04Z
dc.date.issued 2014
dc.identifier.citation Vrijheid M, Slama R, Robinson O, Chatzi L, Coen M, van den Hazel P et al. The human early-life exposome (HELIX): project rationale and design. Environ Health Perspect. 2014;122(6):535-44. DOI: 10.1289/ehp.1307204
dc.identifier.issn 0091-6765
dc.identifier.uri http://hdl.handle.net/10230/23394
dc.description.abstract Background: Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused on single exposure–health effect relationships. The “exposome” concept encompasses the totality of exposures from conception onward, complementing the genome. Objectives: The Human Early-Life Exposome (HELIX) project is a new collaborative research project that aims to implement novel exposure assessment and biomarker methods to characterize early-life exposure to multiple environmental factors and associate these with omics biomarkers and child health outcomes, thus characterizing the “early-life exposome.” Here we describe the general design of the project. Methods: In six existing birth cohort studies in Europe, HELIX will estimate prenatal and postnatal exposure to a broad range of chemical and physical exposures. Exposure models will be developed for the full cohorts totaling 32,000 mother–child pairs, and biomarkers will be measured in a subset of 1,200 mother–child pairs. Nested repeat-sampling panel studies (n = 150) will collect data on biomarker variability, use smartphones to assess mobility and physical activity, and perform personal exposure monitoring. Omics techniques will determine molecular profiles (metabolome, proteome, transcriptome, epigenome) associated with exposures. Statistical methods for multiple exposures will provide exposure–response estimates for fetal and child growth, obesity, neurodevelopment, and respiratory outcomes. A health impact assessment exercise will evaluate risks and benefits of combined exposures. Conclusions: HELIX is one of the first attempts to describe the early-life exposome of European populations and unravel its relation to omics markers and health in childhood. As proof of concept, it will form an important first step toward the life-course exposome.
dc.description.sponsorship This research received funding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement 308333–the HELIX project
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher National Institute of Environmental Health Sciences (NIEHS)
dc.relation.ispartof Environmental Health Perspectives. 2014;122(6):535-44
dc.rights Reproduced with permission from Environmental Health Perspectives
dc.subject.other Malalties immunològiques en els infants
dc.subject.other Infants -- Desenvolupament
dc.subject.other Salut ambiental
dc.title The Human Early-Life Exposome (HELIX): project rationale and design
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1289/ehp.1307204
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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