The Human Early-Life Exposome (HELIX): project rationale and design
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- dc.contributor.author Vrijheid, Martineca
- dc.contributor.author Robinson, Oliverca
- dc.contributor.author Basagaña Flores, Xavierca
- dc.contributor.author Bustamante Pineda, Marionaca
- dc.contributor.author Casas Sanahuja, Maribelca
- dc.contributor.author Estivill, Xavier, 1955-ca
- dc.contributor.author van Gent, Dianaca
- dc.contributor.author González Ruiz, Juan Ramónca
- dc.contributor.author Júlvez Calvo, Jordica
- dc.contributor.author Kogevinas, Manolisca
- dc.contributor.author Sabidó Aguadé, Eduard, 1981-ca
- dc.contributor.author Sunyer Deu, Jordica
- dc.contributor.author Nieuwenhuijsen, Mark J.ca
- dc.date.accessioned 2015-04-13T07:30:04Z
- dc.date.available 2015-04-13T07:30:04Z
- dc.date.issued 2014ca
- dc.description.abstract Background: Developmental periods in early life may be particularly vulnerable to impacts of environmental exposures. Human research on this topic has generally focused on single exposure–health effect relationships. The “exposome” concept encompasses the totality of exposures from conception onward, complementing the genome. Objectives: The Human Early-Life Exposome (HELIX) project is a new collaborative research project that aims to implement novel exposure assessment and biomarker methods to characterize early-life exposure to multiple environmental factors and associate these with omics biomarkers and child health outcomes, thus characterizing the “early-life exposome.” Here we describe the general design of the project. Methods: In six existing birth cohort studies in Europe, HELIX will estimate prenatal and postnatal exposure to a broad range of chemical and physical exposures. Exposure models will be developed for the full cohorts totaling 32,000 mother–child pairs, and biomarkers will be measured in a subset of 1,200 mother–child pairs. Nested repeat-sampling panel studies (n = 150) will collect data on biomarker variability, use smartphones to assess mobility and physical activity, and perform personal exposure monitoring. Omics techniques will determine molecular profiles (metabolome, proteome, transcriptome, epigenome) associated with exposures. Statistical methods for multiple exposures will provide exposure–response estimates for fetal and child growth, obesity, neurodevelopment, and respiratory outcomes. A health impact assessment exercise will evaluate risks and benefits of combined exposures. Conclusions: HELIX is one of the first attempts to describe the early-life exposome of European populations and unravel its relation to omics markers and health in childhood. As proof of concept, it will form an important first step toward the life-course exposome.en
- dc.description.sponsorship This research received funding from the European Community’s Seventh Framework Programme (FP7/2007-2013) under grant agreement 308333–the HELIX projecten
- dc.format.mimetype application/pdfca
- dc.identifier.citation Vrijheid M, Slama R, Robinson O, Chatzi L, Coen M, van den Hazel P et al. The human early-life exposome (HELIX): project rationale and design. Environ Health Perspect. 2014;122(6):535-44. DOI: 10.1289/ehp.1307204ca
- dc.identifier.doi http://dx.doi.org/10.1289/ehp.1307204
- dc.identifier.issn 0091-6765ca
- dc.identifier.uri http://hdl.handle.net/10230/23394
- dc.language.iso engca
- dc.publisher National Institute of Environmental Health Sciences (NIEHS)ca
- dc.relation.ispartof Environmental Health Perspectives. 2014;122(6):535-44
- dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
- dc.rights Reproduced with permission from Environmental Health Perspectivesca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.subject.other Malalties immunològiques en els infants
- dc.subject.other Infants -- Desenvolupamentca
- dc.subject.other Salut ambientalca
- dc.title The Human Early-Life Exposome (HELIX): project rationale and designen
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca