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Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine

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dc.contributor.author Varani, Andrés P.
dc.contributor.author Aso Pérez, Ester
dc.contributor.author Maldonado, Rafael, 1961-
dc.contributor.author Balerio, Graciela N.
dc.date.accessioned 2015-04-01T07:31:42Z
dc.date.available 2015-04-01T07:31:42Z
dc.date.issued 2014
dc.identifier.citation Varani AP, Aso E, Maldonado R, Balerio GN. Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine. Eur J Pharmacol. 2014 Sep 5;738:200-5. DOI: 10.1016/j.ejphar.2014.05.039
dc.identifier.issn 0014-2999
dc.identifier.uri http://hdl.handle.net/10230/23334
dc.description.abstract The aim of the present study was to evaluate the possible involvement of GABAB receptors in nicotine-induced hypolocomotion and antinociceptive effects in mice. Animals were exposed to nicotine only once. Acute nicotine hydrogen tartrate salt (3mg/kg; subcutaneous, s.c.) administration induced hypolocomotion and antinociceptive responses in the tail-immersion and the hot-plate tests. The effects of pretreatment with either the GABAB receptor agonist baclofen (1, 2 and 3mg/kg; intraperitoneal, i.p.) or GABAB receptor antagonist 2-hydroxysaclofen (0.25, 0.5 and 1mg/kg; i.p.) were evaluated on these behavioral nicotine responses. The GABAB receptor agonist, baclofen (3mg/kg, i.p.) abolished nicotine-induced antinociceptive effects in the tail-immersion and the hot-plate tests, but did not modify nicotine-induced hypolocomotion. In addition, the GABAB receptor antagonist, 2-hydroxysaclofen (1mg/kg, i.p.) increased nicotine-induced antinociceptive effects in the tail-immersion and the hot-plate tests, and abolished nicotine-induced hypolocomotion. The present results shed light that the GABAB receptor has an important role in mediating specific acute nicotine responses such as hypolocomotion and antinociception in mice.
dc.description.sponsorship This work has been supported by grants from University of Buenos Aires (UBACyT B016 and UBACyT 2013–2016 No. 20020120100244), CONICET (PIP 11420090100303), Spanish “Ministerio de Ciencia e Innovación” (#SAF2011-29864), “Instituto de Salud Carlos III” (RETICS: #RD06/0001/0001, #RD06/0001/1004), Plan Nacional sobre Drogas (PNSD #2009/026), the Catalan Government (SGR2009-00131) and the ICREA Foundation (ICREA Academia-2008)
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof European Journal of Pharmacology. 2014 Sep 5;738:200-5
dc.rights © Elsevier http://dx.doi.org/10.1016/j.ejphar.2014.05.039
dc.subject.other Nicotina
dc.subject.other Ratolins
dc.title Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1016/j.ejphar.2014.05.039
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-29864
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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