Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine

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• dc.contributor.author Varani, Andrés P.ca
• dc.contributor.author Aso Pérez, Esterca
• dc.contributor.author Maldonado, Rafael, 1961-ca
• dc.contributor.author Balerio, Graciela N.ca
• dc.date.accessioned 2015-04-01T07:31:42Z
• dc.date.available 2015-04-01T07:31:42Z
• dc.date.issued 2014ca
• dc.description.abstract The aim of the present study was to evaluate the possible involvement of GABAB receptors in nicotine-induced hypolocomotion and antinociceptive effects in mice. Animals were exposed to nicotine only once. Acute nicotine hydrogen tartrate salt (3mg/kg; subcutaneous, s.c.) administration induced hypolocomotion and antinociceptive responses in the tail-immersion and the hot-plate tests. The effects of pretreatment with either the GABAB receptor agonist baclofen (1, 2 and 3mg/kg; intraperitoneal, i.p.) or GABAB receptor antagonist 2-hydroxysaclofen (0.25, 0.5 and 1mg/kg; i.p.) were evaluated on these behavioral nicotine responses. The GABAB receptor agonist, baclofen (3mg/kg, i.p.) abolished nicotine-induced antinociceptive effects in the tail-immersion and the hot-plate tests, but did not modify nicotine-induced hypolocomotion. In addition, the GABAB receptor antagonist, 2-hydroxysaclofen (1mg/kg, i.p.) increased nicotine-induced antinociceptive effects in the tail-immersion and the hot-plate tests, and abolished nicotine-induced hypolocomotion. The present results shed light that the GABAB receptor has an important role in mediating specific acute nicotine responses such as hypolocomotion and antinociception in mice.
• dc.description.sponsorship This work has been supported by grants from University of Buenos Aires (UBACyT B016 and UBACyT 2013–2016 No. 20020120100244), CONICET (PIP 11420090100303), Spanish “Ministerio de Ciencia e Innovación” (#SAF2011-29864), “Instituto de Salud Carlos III” (RETICS: #RD06/0001/0001, #RD06/0001/1004), Plan Nacional sobre Drogas (PNSD #2009/026), the Catalan Government (SGR2009-00131) and the ICREA Foundation (ICREA Academia-2008)
• dc.format.mimetype application/pdfca
• dc.identifier.citation Varani AP, Aso E, Maldonado R, Balerio GN. Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotine. Eur J Pharmacol. 2014 Sep 5;738:200-5. DOI: 10.1016/j.ejphar.2014.05.039ca
• dc.identifier.doi http://dx.doi.org/10.1016/j.ejphar.2014.05.039
• dc.identifier.issn 0014-2999ca
• dc.identifier.uri http://hdl.handle.net/10230/23334
• dc.language.iso engca
• dc.publisher Elsevierca
• dc.relation.ispartof European Journal of Pharmacology. 2014 Sep 5;738:200-5
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-29864
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.ejphar.2014.05.039ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.other Nicotina
• dc.subject.other Ratolins
• dc.title Baclofen and 2-hydroxysaclofen modify acute hypolocomotive and antinociceptive effects of nicotineca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/acceptedVersionca