Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice

Martín García, Elena, 1975-; Mannara, Francesco; Gutiérrez Cuesta, Javier; Sabater, Lidia; Dalmau, Josep; Maldonado, Rafael, 1961-; Graus, Francesc

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dc.contributor.author	Martín García, Elena, 1975-
dc.contributor.author	Mannara, Francesco
dc.contributor.author	Gutiérrez Cuesta, Javier
dc.contributor.author	Sabater, Lidia
dc.contributor.author	Dalmau, Josep
dc.contributor.author	Maldonado, Rafael, 1961-
dc.contributor.author	Graus, Francesc
dc.date.accessioned	2015-04-01T07:31:35Z
dc.date.available	2015-04-01T07:31:35Z
dc.date.issued	2013
dc.identifier.citation	Martín-García E, Mannara F, Gutiérrez-Cuesta J, Sabater L, Dalmau J, Maldonado R et al. Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice. J Neuroimmunol. 2013 Aug 15; 261(1-2): 53-9. DOI: 10.1016/j.jneuroim.2013.05.003
dc.identifier.issn	0165-5728
dc.identifier.uri	http://hdl.handle.net/10230/23332
dc.description.abstract	The role of antibodies against the P/Q type voltage-gated calcium channels (VGCC-ab) in the pathogenesis of paraneoplastic cerebellar degeneration (PCD) and lung cancer is unclear. We evaluated in mice the effect of intrathecal injection of IgG purified from serum of a patient with both PCD and Lambert-Eaton myasthenic syndrome (LEMS), and from another patient with isolated LEMS. Mice injected with PCD/LEMS IgG developed marked, reversible ataxia compared with those injected with LEMS or control IgG. These findings suggest that P/Q-type VGCC-ab may play a role in the pathogenesis of ataxia in patients with PCD and SCLC.
dc.description.sponsorship	This study was supported in part by grants PS09/0193 (FG) and PS11/01780 (JD) from Fondo de Investigaciones Sanitarias, Madrid; grant from Fundació la Marató de TV3 (JD), Barcelona; and grants from the “Ministerio de Ciencia e Innovación” (SAF2007-64062), and “Instituto de Salud Carlos III” (RETICS-Red de Trastornos Adictivos-Redes Temáticas de Investigación Cooperativa en Salud: RD06/0001/0001, RD06/0001/1004) (RM), Spain.The partial support of FEDER funds (EU) is also acknowledged
dc.format.mimetype	application/pdf
dc.language.iso	eng
dc.publisher	Elsevier
dc.relation.ispartof	Journal of Neuroimmunology. 2013 Aug 15;261(1-2):53-9
dc.rights	© Elsevier http://dx.doi.org/10.1016/j.jneuroim.2013.05.003
dc.subject.other	Autoanticossos -- Toxicologia
dc.subject.other	Canals de calci -- Immunologia
dc.subject.other	Cervell
dc.title	Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	http://dx.doi.org/10.1016/j.jneuroim.2013.05.003
dc.relation.projectID	info:eu-repo/grantAgreement/ES/2PN/SAF2007-64062
dc.rights.accessRights	info:eu-repo/semantics/openAccess
dc.type.version	info:eu-repo/semantics/acceptedVersion