dc.contributor.author |
Martín García, Elena, 1975- |
dc.contributor.author |
Mannara, Francesco |
dc.contributor.author |
Gutiérrez Cuesta, Javier |
dc.contributor.author |
Sabater, Lidia |
dc.contributor.author |
Dalmau, Josep |
dc.contributor.author |
Maldonado, Rafael, 1961- |
dc.contributor.author |
Graus, Francesc |
dc.date.accessioned |
2015-04-01T07:31:35Z |
dc.date.available |
2015-04-01T07:31:35Z |
dc.date.issued |
2013 |
dc.identifier.citation |
Martín-García E, Mannara F, Gutiérrez-Cuesta J, Sabater L, Dalmau J, Maldonado R et al. Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice. J Neuroimmunol. 2013 Aug 15; 261(1-2): 53-9. DOI: 10.1016/j.jneuroim.2013.05.003 |
dc.identifier.issn |
0165-5728 |
dc.identifier.uri |
http://hdl.handle.net/10230/23332 |
dc.description.abstract |
The role of antibodies against the P/Q type voltage-gated calcium channels (VGCC-ab) in the pathogenesis of paraneoplastic cerebellar degeneration (PCD) and lung cancer is unclear. We evaluated in mice the effect of intrathecal injection of IgG purified from serum of a patient with both PCD and Lambert-Eaton myasthenic syndrome (LEMS), and from another patient with isolated LEMS. Mice injected with PCD/LEMS IgG developed marked, reversible ataxia compared with those injected with LEMS or control IgG. These findings suggest that P/Q-type VGCC-ab may play a role in the pathogenesis of ataxia in patients with PCD and SCLC. |
dc.description.sponsorship |
This study was supported in part by grants PS09/0193 (FG) and PS11/01780 (JD) from Fondo de Investigaciones Sanitarias, Madrid; grant from Fundació la Marató de TV3 (JD), Barcelona; and grants from the “Ministerio de Ciencia e Innovación” (SAF2007-64062), and “Instituto de Salud Carlos III” (RETICS-Red de Trastornos Adictivos-Redes Temáticas de Investigación Cooperativa en Salud: RD06/0001/0001, RD06/0001/1004) (RM), Spain.The partial support of FEDER funds (EU) is also acknowledged |
dc.format.mimetype |
application/pdf |
dc.language.iso |
eng |
dc.publisher |
Elsevier |
dc.relation.ispartof |
Journal of Neuroimmunology. 2013 Aug 15;261(1-2):53-9 |
dc.rights |
© Elsevier http://dx.doi.org/10.1016/j.jneuroim.2013.05.003 |
dc.subject.other |
Autoanticossos -- Toxicologia |
dc.subject.other |
Canals de calci -- Immunologia |
dc.subject.other |
Cervell |
dc.title |
Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice |
dc.type |
info:eu-repo/semantics/article |
dc.identifier.doi |
http://dx.doi.org/10.1016/j.jneuroim.2013.05.003 |
dc.relation.projectID |
info:eu-repo/grantAgreement/ES/2PN/SAF2007-64062 |
dc.rights.accessRights |
info:eu-repo/semantics/openAccess |
dc.type.version |
info:eu-repo/semantics/acceptedVersion |