Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice

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• dc.contributor.author Martín García, Elena, 1975-ca
• dc.contributor.author Mannara, Francescoca
• dc.contributor.author Gutiérrez Cuesta, Javierca
• dc.contributor.author Sabater, Lidiaca
• dc.contributor.author Dalmau, Josepca
• dc.contributor.author Maldonado, Rafael, 1961-ca
• dc.contributor.author Graus, Francescca
• dc.date.accessioned 2015-04-01T07:31:35Z
• dc.date.available 2015-04-01T07:31:35Z
• dc.date.issued 2013ca
• dc.description.abstract The role of antibodies against the P/Q type voltage-gated calcium channels (VGCC-ab) in the pathogenesis of paraneoplastic cerebellar degeneration (PCD) and lung cancer is unclear. We evaluated in mice the effect of intrathecal injection of IgG purified from serum of a patient with both PCD and Lambert-Eaton myasthenic syndrome (LEMS), and from another patient with isolated LEMS. Mice injected with PCD/LEMS IgG developed marked, reversible ataxia compared with those injected with LEMS or control IgG. These findings suggest that P/Q-type VGCC-ab may play a role in the pathogenesis of ataxia in patients with PCD and SCLC.
• dc.description.sponsorship This study was supported in part by grants PS09/0193 (FG) and PS11/01780 (JD) from Fondo de Investigaciones Sanitarias, Madrid; grant from Fundació la Marató de TV3 (JD), Barcelona; and grants from the “Ministerio de Ciencia e Innovación” (SAF2007-64062), and “Instituto de Salud Carlos III” (RETICS-Red de Trastornos Adictivos-Redes Temáticas de Investigación Cooperativa en Salud: RD06/0001/0001, RD06/0001/1004) (RM), Spain.The partial support of FEDER funds (EU) is also acknowledged
• dc.format.mimetype application/pdfca
• dc.identifier.citation Martín-García E, Mannara F, Gutiérrez-Cuesta J, Sabater L, Dalmau J, Maldonado R et al. Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice. J Neuroimmunol. 2013 Aug 15; 261(1-2): 53-9. DOI: 10.1016/j.jneuroim.2013.05.003ca
• dc.identifier.doi http://dx.doi.org/10.1016/j.jneuroim.2013.05.003
• dc.identifier.issn 0165-5728ca
• dc.identifier.uri http://hdl.handle.net/10230/23332
• dc.language.iso engca
• dc.publisher Elsevierca
• dc.relation.ispartof Journal of Neuroimmunology. 2013 Aug 15;261(1-2):53-9
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/SAF2007-64062
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.jneuroim.2013.05.003ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.other Autoanticossos -- Toxicologia
• dc.subject.other Canals de calci -- Immunologia
• dc.subject.other Cervell
• dc.title Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in miceca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/acceptedVersionca