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Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far

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dc.contributor.author Flores de los Heros, África, 1985-
dc.contributor.author Maldonado, Rafael, 1961-
dc.contributor.author Berrendero Díaz, Fernando, 1971-
dc.date.accessioned 2015-03-23T08:49:15Z
dc.date.available 2015-03-23T08:49:15Z
dc.date.issued 2013
dc.identifier.citation Flores A, Maldonado R, Berrendero F. Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far. Front Neurosci. 2013 Dec 20; 7: 256. DOI: 10.3389/fnins.2013.00256
dc.identifier.issn 1662-4548
dc.identifier.uri http://hdl.handle.net/10230/23254
dc.description.abstract Emerging findings suggest the existence of a cross-talk between hypocretinergic and endocannabinoid systems. Although few studies have examined this relationship, the apparent overlap observed in the neuroanatomical distribution of both systems as well as their putative functions strongly point to the existence of such cross-modulation. In agreement, biochemical and functional studies have revealed the existence of heterodimers between CB1 cannabinoid receptor and hypocretin receptor-1, which modulates the cellular localization and downstream signaling of both receptors. Moreover, the activation of hypocretin receptor-1 stimulates the synthesis of 2-arachidonoyl glycerol culminating in the retrograde inhibition of neighboring cells and suggesting that endocannabinoids could contribute to some hypocretin effects. Pharmacological data indicate that endocannabinoids and hypocretins might have common physiological functions in the regulation of appetite, reward and analgesia. In contrast, these neuromodulatory systems seem to play antagonistic roles in the regulation of sleep/wake cycle and anxiety-like responses. The present review attempts to piece together what is known about this interesting interaction and describes its potential therapeutic implications.
dc.description.sponsorship This work was supported by the Instituto de Salud CarlosIII grants, #PI07/0559, #PI10/00316 and #RD06/001/001 (RTA-RETICS), by the Spanish Ministry of Science and Technology, Consolider-C #SAF2007-64062 and #SAF2011-29864, the Catalan Government (SGR2009-00731), and by the Catalan Institution for Research and Advanced Studies (ICREA Academia program). África Flores is recipient of a predoctoral fellowship from the Spanish Ministry of Education
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Frontiers
dc.rights © 2013 África Flores, Rafael Madonado and Fernando Berrendero Díaz. This is an open-access article distributed under the terms of a Creative Commons Attribution License(CCBY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or/nreproduction is permitted which does not comply with these terms
dc.rights.uri http://creativecommons.org/licenses/by/3.0/
dc.subject.other Sistema nerviós central
dc.subject.other Cannabinoides
dc.title Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.3389/fnins.2013.00256
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/SAF2007-64062
dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-29864
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


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