Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far
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- dc.contributor.author Flores de los Heros, África, 1985-ca
- dc.contributor.author Maldonado, Rafael, 1961-ca
- dc.contributor.author Berrendero Díaz, Fernando, 1971-ca
- dc.date.accessioned 2015-03-23T08:49:15Z
- dc.date.available 2015-03-23T08:49:15Z
- dc.date.issued 2013ca
- dc.description.abstract Emerging findings suggest the existence of a cross-talk between hypocretinergic and endocannabinoid systems. Although few studies have examined this relationship, the apparent overlap observed in the neuroanatomical distribution of both systems as well as their putative functions strongly point to the existence of such cross-modulation. In agreement, biochemical and functional studies have revealed the existence of heterodimers between CB1 cannabinoid receptor and hypocretin receptor-1, which modulates the cellular localization and downstream signaling of both receptors. Moreover, the activation of hypocretin receptor-1 stimulates the synthesis of 2-arachidonoyl glycerol culminating in the retrograde inhibition of neighboring cells and suggesting that endocannabinoids could contribute to some hypocretin effects. Pharmacological data indicate that endocannabinoids and hypocretins might have common physiological functions in the regulation of appetite, reward and analgesia. In contrast, these neuromodulatory systems seem to play antagonistic roles in the regulation of sleep/wake cycle and anxiety-like responses. The present review attempts to piece together what is known about this interesting interaction and describes its potential therapeutic implications.
- dc.description.sponsorship This work was supported by the Instituto de Salud CarlosIII grants, #PI07/0559, #PI10/00316 and #RD06/001/001 (RTA-RETICS), by the Spanish Ministry of Science and Technology, Consolider-C #SAF2007-64062 and #SAF2011-29864, the Catalan Government (SGR2009-00731), and by the Catalan Institution for Research and Advanced Studies (ICREA Academia program). África Flores is recipient of a predoctoral fellowship from the Spanish Ministry of Education
- dc.format.mimetype application/pdfca
- dc.identifier.citation Flores A, Maldonado R, Berrendero F. Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so far. Front Neurosci. 2013 Dec 20;7:256. DOI: 10.3389/fnins.2013.00256ca
- dc.identifier.doi http://dx.doi.org/10.3389/fnins.2013.00256
- dc.identifier.issn 1662-4548ca
- dc.identifier.uri http://hdl.handle.net/10230/23254
- dc.language.iso engca
- dc.publisher Frontiersca
- dc.relation.ispartof Frontiers in Neuroscience. 2013 Dec 20;7:256
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/SAF2007-64062
- dc.relation.projectID info:eu-repo/grantAgreement/ES/3PN/SAF2011-29864
- dc.rights © 2013 África Flores, Rafael Madonado and Fernando Berrendero Díaz. This is an open-access article distributed under the terms of a Creative Commons Attribution License(CCBY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or/nreproduction is permitted which does not comply with these termsca
- dc.rights.accessRights info:eu-repo/semantics/openAccessca
- dc.rights.uri http://creativecommons.org/licenses/by/3.0/
- dc.subject.other Sistema nerviós central
- dc.subject.other Cannabinoides
- dc.title Cannabinoid-hypocretin cross-talk in the central nervous system: what we know so farca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/publishedVersionca