Welcome to the UPF Digital Repository

Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest

Show simple item record

dc.contributor.author Hagen, Ferry
dc.contributor.author Ceresini, Paulo C.
dc.contributor.author Polacheck, Itzhack
dc.contributor.author Ma, Hansong
dc.contributor.author Nieuwerburgh, Filip van
dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-
dc.contributor.author Kagan, Sarah
dc.contributor.author Pursall, E. Rhiannon
dc.contributor.author Hoogveld, Hans L.
dc.contributor.author Iersel, Leo J. van
dc.contributor.author Klau, Gunnar W.
dc.contributor.author Kelk, Steven M.
dc.contributor.author Stougie, Leen
dc.contributor.author Bartlett, Karen H.
dc.contributor.author Voelz, Kerstin
dc.contributor.author Pryszcz, Leszek Piotr, 1985-
dc.contributor.author Castañeda, Elizabeth
dc.contributor.author Lazera, Marcia
dc.contributor.author Meyer, Wieland
dc.contributor.author Deforce, Dieter
dc.contributor.author Meis, Jacques F.
dc.contributor.author May, Robin C.
dc.contributor.author Klaassen, Corné H. W.
dc.contributor.author Boekhout, Teun
dc.date.accessioned 2014-05-12T13:19:11Z
dc.date.available 2014-05-12T13:19:11Z
dc.date.issued 2013
dc.identifier.citation Hagen F, Ceresini PC, Polacheck I, Ma H, van Nieuwerburgh F, Gabaldón T et al. Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest. PLoS One. 2013;8(8):e71148. DOI: 10.1371/journal.pone.0071148
dc.identifier.issn 1932-6203
dc.identifier.uri http://hdl.handle.net/10230/22479
dc.description.abstract Over the past two decades, several fungal outbreaks have occurred, including the high-profile 'Vancouver Island' and 'Pacific Northwest' outbreaks, caused by Cryptococcus gattii, which has affected hundreds of otherwise healthy humans and animals. Over the same time period, C. gattii was the cause of several additional case clusters at localities outside of the tropical and subtropical climate zones where the species normally occurs. In every case, the causative agent belongs to a previously rare genotype of C. gattii called AFLP6/VGII, but the origin of the outbreak clades remains enigmatic. Here we used phylogenetic and recombination analyses, based on AFLP and multiple MLST datasets, and coalescence gene genealogy to demonstrate that these outbreaks have arisen from a highly-recombining C. gattii population in the native rainforest of Northern Brazil. Thus the modern virulent C. gattii AFLP6/VGII outbreak lineages derived from mating events in South America and then dispersed to temperate regions where they cause serious infections in humans and animals.
dc.description.sponsorship This publication was made possible by NPRP grant 5-298-3-06 from the Qatar National Research Fund (a member of Qatar foundation) to TB, JFM, CHWK, and TG. Computational experiments were sponsored by the NCF (Netherlands Computer Facility Foundation) for the use of supercomputer facilities, with/nfinancial support from NWO (Nederlandse Organisatie voor Wetenschappelijk Onderzoek). Contributions of FH were supported by the Odo van Vloten Foundation
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Public Library of Science (PLoS)
dc.relation.ispartof PLoS One. 2013;8(8):e71148
dc.rights © 2013 Ferry Hagen et al. This article is distributed under a Creative Commons Attribution License
dc.rights.uri http://creativecommons.org/licenses/by/2.5/
dc.subject.other Llevats -- Genètica
dc.subject.other Criptococcosi
dc.subject.other Criptococ
dc.title Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0071148
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion


This item appears in the following Collection(s)

Show simple item record

Search DSpace

Advanced Search


My Account


Compliant to Partaking