Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest

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• dc.contributor.author Hagen, Ferryca
• dc.contributor.author Ceresini, Paulo C.ca
• dc.contributor.author Polacheck, Itzhackca
• dc.contributor.author Ma, Hansongca
• dc.contributor.author Nieuwerburgh, Filip vanca
• dc.contributor.author Gabaldón Estevan, Juan Antonio, 1973-ca
• dc.contributor.author Kagan, Sarahca
• dc.contributor.author Pursall, E. Rhiannonca
• dc.contributor.author Hoogveld, Hans L.ca
• dc.contributor.author Iersel, Leo J. vanca
• dc.contributor.author Klau, Gunnar W.ca
• dc.contributor.author Kelk, Steven M.ca
• dc.contributor.author Stougie, Leenca
• dc.contributor.author Bartlett, Karen H.ca
• dc.contributor.author Voelz, Kerstinca
• dc.contributor.author Pryszcz, Leszek Piotr, 1985-ca
• dc.contributor.author Castañeda, Elizabethca
• dc.contributor.author Lazera, Marciaca
• dc.contributor.author Meyer, Wielandca
• dc.contributor.author Deforce, Dieterca
• dc.contributor.author Meis, Jacques F.ca
• dc.contributor.author May, Robin C.ca
• dc.contributor.author Klaassen, Corné H. W.ca
• dc.contributor.author Boekhout, Teunca
• dc.date.accessioned 2014-05-12T13:19:11Z
• dc.date.available 2014-05-12T13:19:11Z
• dc.date.issued 2013ca
• dc.description.abstract Over the past two decades, several fungal outbreaks have occurred, including the high-profile 'Vancouver Island' and 'Pacific Northwest' outbreaks, caused by Cryptococcus gattii, which has affected hundreds of otherwise healthy humans and animals. Over the same time period, C. gattii was the cause of several additional case clusters at localities outside of the tropical and subtropical climate zones where the species normally occurs. In every case, the causative agent belongs to a previously rare genotype of C. gattii called AFLP6/VGII, but the origin of the outbreak clades remains enigmatic. Here we used phylogenetic and recombination analyses, based on AFLP and multiple MLST datasets, and coalescence gene genealogy to demonstrate that these outbreaks have arisen from a highly-recombining C. gattii population in the native rainforest of Northern Brazil. Thus the modern virulent C. gattii AFLP6/VGII outbreak lineages derived from mating events in South America and then dispersed to temperate regions where they cause serious infections in humans and animals.
• dc.description.sponsorship This publication was made possible by NPRP grant 5-298-3-06 from the Qatar National Research Fund (a member of Qatar foundation) to TB, JFM, CHWK, and TG. Computational experiments were sponsored by the NCF (Netherlands Computer Facility Foundation) for the use of supercomputer facilities, with/nfinancial support from NWO (Nederlandse Organisatie voor Wetenschappelijk Onderzoek). Contributions of FH were supported by the Odo van Vloten Foundation
• dc.format.mimetype application/pdfca
• dc.identifier.citation Hagen F, Ceresini PC, Polacheck I, Ma H, van Nieuwerburgh F, Gabaldón T et al. Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforest. PLoS One. 2013;8(8):e71148. DOI: 10.1371/journal.pone.0071148ca
• dc.identifier.doi http://dx.doi.org/10.1371/journal.pone.0071148
• dc.identifier.issn 1932-6203ca
• dc.identifier.uri http://hdl.handle.net/10230/22479
• dc.language.iso engca
• dc.publisher Public Library of Science (PLoS)ca
• dc.relation.ispartof PLoS One. 2013;8(8):e71148
• dc.rights © 2013 Ferry Hagen et al. This article is distributed under a Creative Commons Attribution Licenseca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.rights.uri http://creativecommons.org/licenses/by/2.5/
• dc.subject.other Llevats -- Genètica
• dc.subject.other Criptococcosi
• dc.subject.other Criptococ
• dc.title Ancient dispersal of the human fungal pathogen Cryptococcus gattii from the Amazon rainforestca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca