Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

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Recent Submissions

  • Stik, Grégoire; Vidal, Enrique; Barrero, Mercedes; Cuartero, Sergi; Vila-Casadesús, Maria; Mendieta-Esteban, Julen; Tian, Tian V.; Choi, Jinmi; Berenguer, Clara; Abad, Amaya; Borsari, Beatrice; Le Dily, François; Cramer, Patrick; Martí Renom, Marc A.; Stadhouders, Ralph; Graf, T. (Thomas) (Nature Research, 2020)
    Three-dimensional organization of the genome is important for transcriptional regulation1-7. In mammals, CTCF and the cohesin complex create submegabase structures with elevated internal chromatin contact frequencies, ...
  • Encode Project Consortium; Snyder, Michael; Myers, Richard M. (Nature Research, 2020)
    The Encylopedia of DNA Elements (ENCODE) Project launched in 2003 with the long-term goal of developing a comprehensive map of functional elements in the human genome. These included genes, biochemical regions associated ...
  • Ramilowski, Jordan A.; Borsari, Beatrice; Garrido Martín, Diego, 1992-; Muñoz-Aguirre, Manuel; Nurtdinov, Ramil; Guigó Serra, Roderic; Carninci, Piero (Cold Spring Harbor Laboratory Press (CSHL Press), 2020)
    Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we systematically knocked down the expression ...
  • Encode Project Consortium; Moore, Jill E.; Guigó Serra, Roderic; Weng, Zhiping (Nature Research, 2020)
    The human and mouse genomes contain instructions that specify RNAs and proteins and govern the timing, magnitude, and cellular context of their production. To better delineate these elements, phase III of the Encyclopedia ...
  • Rispe, Claude; Fernández, Rosa; Gabaldón Estevan, Juan Antonio, 1973-; Guigó Serra, Roderic; Ripoll Cladellas, Aida; Tagu, Denis (BioMed Central, 2020)
    Background: Although native to North America, the invasion of the aphid-like grape phylloxera Daktulosphaira vitifoliae across the globe altered the course of grape cultivation. For the past 150 years, viticulture relied ...
  • Khan, Naazneen; de Manuel, Marc; Peyregne, Stephane; Do, Raymond; Prufer, Kay; Marquès i Bonet, Tomàs, 1975-; Varki, Nissi; Gagneux, Pascal; Varki, Ajit (Oxford University Press, 2020)
    Human-specific pseudogenization of the CMAH gene eliminated the mammalian sialic acid (Sia) Neu5Gc (generating an excess of its precursor Neu5Ac), thus changing ubiquitous cell surface "self-associated molecular patterns" ...
  • Muyas Remolar, Francesc, 1992-; Zapata Ortiz, Luis, 1985-; Guigó Serra, Roderic; Ossowski, Stephan (BioMed Central, 2020)
    Background: Mosaic mutations acquired during early embryogenesis can lead to severe early-onset genetic disorders and cancer predisposition, but are often undetectable in blood samples. The rate and mutational spectrum of ...
  • Marcet Houben, Marina; Gabaldón Estevan, Juan Antonio, 1973- (Nature Research, 2019)
    Gene clusters comprise genomically co-localized and potentially co-regulated genes that tend to be conserved across species. In eukaryotes, multiple examples of metabolic gene clusters are known, particularly among fungi ...
  • de Manuel, Marc; Marquès i Bonet, Tomàs, 1975-; Gilbert, M Thomas (National Academy of Sciences, 2020)
    Lions are one of the world's most iconic megafauna, yet little is known about their temporal and spatial demographic history and population differentiation. We analyzed a genomic dataset of 20 specimens: two ca. 30,000-y-old ...
  • Brasó-Vives, Marina, 1990-; Povolotskaya, Inna, 1986-; Hartasánchez Frenk, Diego Andrés, 1982-; Farré, Xavier; Fernández Callejo, Marcos; Raveendran, Muthuswamy; Harris, R. Alan; Rosene, Douglas L.; Lorente Galdós, Maria Belén; Navarro i Cuartiellas, Arcadi, 1969-; Marquès i Bonet, Tomàs, 1975-; Rogers, Jeffrey; Juan Sopeña, David Alejandro, 1975- (Public Library of Science (PLoS), 2020)
    The rhesus macaque is an abundant species of Old World monkeys and a valuable model organism for biomedical research due to its close phylogenetic relationship to humans. Copy number variation is one of the main sources ...
  • Heredia Genestar, José María, 1985-; Marquès i Bonet, Tomàs, 1975-; Juan Sopeña, David Alejandro, 1975-; Navarro i Cuartiellas, Arcadi, 1969- (Nature Research, 2020)
    Mutations do not accumulate uniformly across the genome. Human germline and tumor mutation density correlate poorly, and each is associated with different genomic features. Here, we use non-human great ape (NHGA) germlines ...
  • Ivanova, Tsvetomira Georgieva, 1978-; Maier, Michael, 1983-; Missarova, Alsu, 1990-; Ziegler-Birling, Céline; Dam, Monica; Gomar-Alba, Mercè; Carey, Lucas, 1980-; Mendoza, Manuel (Mendoza Palomares) (Nature Research, 2020)
    To faithfully transmit genetic information, cells must replicate their entire genome before division. This is thought to be ensured by the temporal separation of replication and chromosome segregation. Here we show that ...
  • Escaramís, Geòrgia; Docampo, Elisa; Rabionet, Raquel (Oxford University Press, 2015)
    In the past decade, the view on genomic structural variation (SV) has been changed completely. SVs, previously considered rare events, are now recognized as the largest source of interindividual genetic variation affecting ...
  • Mereu, Elisabetta; Lafzi, Atefeh; Moutinho, Catia; Gut, Marta; Gut, Ivo Glynne; Heyn, Holger (Nature Research, 2020)
    Single-cell RNA sequencing (scRNA-seq) is the leading technique for characterizing the transcriptomes of individual cells in a sample. The latest protocols are scalable to thousands of cells and are being used to compile ...
  • Ritschka, Birgit,1985-; Knauer-Meyer, Tania; Sampaio Gonçalves, Daniel; Mas, Alba; Plassat, Jean-Luc; Durik, Matej; Jacobs, Hugues; Pedone, Elisa, 1985-; Di Vicino, Umberto; Cosma, Maria Pia, 1970-; Keyes, William M., 1973- (Cold Spring Harbor Laboratory Press (CSHL Press), 2020)
    Young mammals possess a limited regenerative capacity in some tissues, which is lost upon maturation. We investigated whether cellular senescence might play a role in such loss during liver regeneration. We found that ...
  • Costa Borges, Nuno; Spath, Katharina; Miguel Escalada, Irene; Mestres, Enric; Balmaseda, Rosa; Serafín, Anna; Garcia Jiménez, Maria; Vanrell, Ivette; González, Jesús; Rink, Klaus; Wells, Dagan; Calderón, Gloria (eLife, 2020)
    The developmental potential of early embryos is mainly dictated by the quality of the oocyte. Here, we explore the utility of the maternal spindle transfer (MST) technique as a reproductive approach to enhance oocyte ...
  • Naranjo Ortiz, Miguel Ángel, 1989-; Gabaldón Estevan, Juan Antonio, 1973- (Wiley, 2020)
    The question of how phenotypic and genomic complexity are inter-related and how they are shaped through evolution is a central question in biology that historically has been approached from the perspective of animals and ...
  • Pegueroles Queralt, Maria Cinta; Mixão, Verónica; Carreté Muñoz, Laia, 1990-; Molina, Manuel; Gabaldón Estevan, Juan Antonio, 1973- (Oxford University Press, 2020)
    SUMMARY: An increasing number of phased (i.e. with resolved haplotypes) reference genomes are available. However, the most genetic variant calling tools do not explicitly account for haplotype structure. Here, we present ...
  • Cruz Garcia, David; Brouwers, Nathalie; Malhotra, Vivek; Curwin, Amy (Rockefeller University Press, 2020)
    Nutrient deprivation triggers the release of signal-sequence-lacking Acb1 and the antioxidant superoxide dismutase 1 (SOD1). We now report that secreted SOD1 is functionally active and accompanied by export of other ...
  • Alonso Alonso, Ruth; Mondéjar, Rufino; Martínez, Nerea; García Diaz, Nuria; Pérez, Cristina; Merino, David; Rodríguez, Marta; Esteve-Codina, Anna; Fusté, Berta; Gut, Marta; Burrows, Francis; Scholz, Catherine; Vaqué, José Pedro; Gualberto, Antonio; Piris, Miguel A. (Nature Research, 2020)
    Patients diagnosed with T-cell leukemias and T-cell lymphomas (TCLs) still have a poor prognosis and an inadequate response to current therapies, highlighting the need for targeted treatments. We have analyzed the potential ...

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