Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

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Recent Submissions

  • Ramayo-Caldas, Yuliaxis; Crespo-Piazuelo, Daniel; Morata, Jordi; González-Rodríguez, Olga; Sebastià, Cristina; Castelló, Anna; Dalmau, Antoni; Ramos-Onsins, Sebastián; Alexiou, Konstantinos G.; Folch, Josep M.; Quintanilla, Raquel; Ballester Devís, Maria (American Society for Microbiology, 2023)
    Genetic variation in the pig genome partially modulates the composition of porcine gut microbial communities. Previous studies have been focused on the association between single nucleotide polymorphisms (SNPs) and the gut ...
  • Proietti, Silvia; Falconieri, Gaia Salvatore; Bertini, Laura; Pascale, Alberto; Bizzarri, Elisabetta; Morales Sanfrutos, Julia; Sabidó Aguadé, Eduard, 1981-; Ruocco, Michelina; Monti, Maurilia M.; Russo, Assunta; Dziurka, Kinga; Ceci, Marcello; Loreto, Francesco; Caruso, Carla (Oxford University Press, 2023)
    Plant roots can exploit beneficial associations with soil-inhabiting microbes, promoting growth and expanding the immune capacity of the host plant. In this work, we aimed to provide new information on changes occurring ...
  • Gómez-Garrido, Jèssica; Cruz, Fernando; Alioto, Tyler; Feiner, Nathalie; Uller, Tobias; Gut, Marta; Sanchez Escudero, Ignacio; Tavecchia, Giacomo; Rotger, Andreu; Otalora Acevedo, Katherin Eliana; Baldo, Laura (Oxford University Press, 2023)
    The Mediterranean lizard Podarcis lilfordi is an emblematic species of the Balearic Islands. The extensive phenotypic diversity among extant isolated populations makes the species a great insular model system for ...
  • Esteller Cucala, Paula; Palmada-Flores, Marc; Kuderna, Lukas F.K.; Fontseré Alemany, Clàudia, 1992-; Serres Armero, Aitor, 1992-; Dabad, Marc; Torralvo, María; Faella, Armida; Ferrández Peral, Luis, 1991-; Llovera Nadal, Laia; Fornas Carreño, Oscar; Julià, Eva; Ramírez, Erika; González, Irene; Hecht, Jochen; Lizano González, Esther, 1974-; Juan, David; Marquès i Bonet, Tomàs, 1975- (Nature Research, 2023)
    Recent advances in long-read sequencing technologies have allowed the generation and curation of more complete genome assemblies, enabling the analysis of traditionally neglected chromosomes, such as the human Y chromosome ...
  • Walters, Rachel; Vasilaki, Eleni; Arman, Jurjan; Chen, Chien-Nien; Wu, Yukyee; Liang, Olin D.; Ashek, Ali; Dubois, Olivier; Zhao, Lin; Sabrin, Farah; Cebola, Inês; Ferrer, Jorge; Morrell, Nicholas W.; Klinger, James R.; Wilkins, Martin R.; Zhao, Lan; Rhodes, Christopher J. (Wolters Kluwer (LWW), 2023)
    Background: Pulmonary arterial hypertension (PAH) is a rare disease characterized by remodeling of the pulmonary arteries, increased vascular resistance, and right-sided heart failure. Genome-wide association studies of ...
  • Coves, Xavier; Bravo, Marc; Huedo, Pol; Conchillo-Solé, Òscar; Gómez, Andromeda-Celeste; Esteve-Codina, Anna; Dabad, Marc; Gut, Marta; Daura, Xavier; Yero, Daniel; Gibert, Isidre (American Society for Microbiology, 2023)
    Stenotrophomonas maltophilia is an environmental bacterium as well as an emerging opportunistic multidrug-resistant pathogen. They use the endogenous diffusible signal factor (DSF) quorum sensing (QS) system to coordinate ...
  • Harris, Hannah L.; Farabella, Irene; Rowley, M. Jordan (Nature Research, 2023)
    Nuclear compartments are prominent features of 3D chromatin organization, but sequencing depth limitations have impeded investigation at ultra fine-scale. CTCF loops are generally studied at a finer scale, but the impact ...
  • Gohr, André; Iñiguez, Luis P.; Torres Méndez, Antonio, 1992-; Bonnal, Sophie; Irimia, Manuel (Oxford University Press, 2023)
    Although splicing occurs largely co-transcriptionally, the order by which introns are removed does not necessarily follow the order in which they are transcribed. Whereas several genomic features are known to influence ...
  • Solá, Paloma; Mereu, Elisabetta; Bonjoch, Júlia; Casado-Peláez, Marta; Prats, Neus; Aguilera, Mònica; Reina García, Óscar, 1976-; Blanco, Enrique; Esteller, Manel; Di Croce, Luciano; Heyn, Holger; Solanas, Guiomar; Aznar Benitah, Salvador (Nature Research, 2023)
    Skin aging is characterized by structural and functional changes that contribute to age-associated frailty. This probably depends on synergy between alterations in the local niche and stem cell-intrinsic changes, underscored ...
  • Matuozzo, Daniela; Gut, Marta; Cobat, Aurélie (BioMed Central, 2023)
    Background: We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases ...
  • São José, Celina; Laurie, Steven, 1973-; Oliveira, Carla (Springer, 2023)
    Background: Germline CDH1 pathogenic or likely pathogenic variants cause hereditary diffuse gastric cancer (HDGC). Once a genetic cause is identified, stomachs' and breasts' surveillance and/or prophylactic surgery is ...
  • Trinidad, Eva María; Juan-Ribelles, Antonio; Pisano, Giulia; Castel, Victoria; Cañete, Adela; Gut, Marta; Heath, Simon; Font de Mora, Jaime (Frontiers, 2023)
    Background: Liquid biopsy has emerged as a promising, non-invasive diagnostic approach in oncology because the analysis of circulating tumor DNA (ctDNA) reflects the precise status of the disease at diagnosis, progression, ...
  • Gómez Garrido, Jèssica; Cruz, Fernando; Alioto, Tyler; Feiner, Nathalie; Uller, Tobias; Sanchez Escudero, Ignacio; Tavecchia, Giacomo; Rotger, Andreu; Otalora Acevedo, Katherin Eliana; Baldo, Laura (Oxford University Press, 2023)
    The Mediterranean lizard Podarcis lilfordi is an emblematic species of the Balearic Islands. The extensive phenotypic diversity among extant isolated populations makes the species a great insular model system for ...
  • Rombauts, Alexander; Bódalo-Torruella, Marta; Abelenda-Alonso, Gabriela; Perera Bel, Júlia; Ferrer Salvador, Anna; Acedo-Terrades, Ariadna; Gabarrós-Subirà, Maria; Oriol, Isabel; Gudiol, Carlota; Nonell Mazelón, Lara; Carratalà, Jordi (MDPI, 2023)
    The clinical manifestations of SARS-CoV-2 infection vary widely, from asymptomatic infection to the development of acute respiratory distress syndrome (ARDS) and death. The host response elicited by SARS-CoV-2 plays a key ...
  • Zhang, Bao-Lin; Marquès i Bonet, Tomàs, 1975-; Wu, Dong-Dong (American Association for the Advancement of Science (AAAS), 2023)
    Although species can arise through hybridization, compelling evidence for hybrid speciation has been reported only rarely in animals. Here, we present phylogenomic analyses on genomes from 12 macaque species and show that ...
  • Moretton, Amandine; Kourtis, Savvas; Gañez-Zapater, Antoni; Calabrò, Chiara; Espinar Calvo, Maria Lorena; Fontaine, Frédéric; Darai, Evangelia; Abad Cortel, Etna; Block, Samuel; Pascual-Reguant, Laura, 1990-; Pardo-Lorente, Natalia; Ghose, Ritobrata; Vander Heiden, Matthew G.; Janic, Ana; Müller, André C.; Loizou, Joanna I.; Sdelci, Sara (EMBO Press, 2023)
    While cellular metabolism impacts the DNA damage response, a systematic understanding of the metabolic requirements that are crucial for DNA damage repair has yet to be achieved. Here, we investigate the metabolic enzymes ...
  • Lobon, Irene; Solís Moruno, Manuel, 1993-; Juan, David; Muhaisen, Ashraf; Abascal, Federico; Esteller Cucala, Paula; García Pérez, Raquel, 1989-; Martí, Maria Josep; Tolosa, Eduard; Ávila, Jesús; Rahbari, Raheleh; Marquès i Bonet, Tomàs, 1975-; Casals López, Ferran; Soriano, Eduardo (Frontiers, 2022)
    The role of somatic mutations in complex diseases, including neurodevelopmental and neurodegenerative disorders, is becoming increasingly clear. However, to date, no study has shown their relation to Parkinson disease's ...
  • Bellmunt Molins, Joaquim, 1959-; Selvarajah, Shamini; Rodig, Scott; Salido Galeote, Marta; Muga, Silvia de; Costa, Irmgard; Bellosillo Paricio, Beatriz; Werner, Lillian; Mullane, Stephanie A.; Fay, André P.; O’Brien, Robert; Barretina, Jordi; Minoche, André E.; Signoretti, Sabina; Montagut Viladot, Clara; Himmelbauer, Heinz; Berman, David M.; Kantoff, Philip; Choueiri, Toni K.; Rosenberg, Jonathan E. (Public Library of Science (PLoS), 2014)
    Anaplastic lymphoma kinase (ALK) genomic alterations have emerged as a potent predictor of benefit from treatment with ALK inhibitors in several cancers. Currently, there is no information about ALK gene alterations in ...
  • Beltran-Sastre, Violeta; Benisty, Hannah, 1986-; Burnier, Julia; Berger, Imre; Serrano Pubull, Luis, 1982-; Kiel, Christina (Nature Research, 2015)
    Understanding the quantitative functional consequences of human disease mutations requires silencing of endogenous genes and expression of mutants at close to physiological levels. Changing protein levels above or below ...
  • Belton, Jon-Matthew; Lajoie, Bryan R.; Audibert, Sylvain; Cantaloube, Sylvain; Lassadi, Imen; Goiffon, Isabelle; Baù, Davide; Marti-Renom, Marc A.; Bystricky, Kerstin; Dekker, Job (Cell Press, 2015)
    Mating-type switching in yeast occurs through gene conversion between the MAT locus and one of two silent loci (HML or HMR) on opposite ends of the chromosome. MATa cells choose HML as template, whereas MATα cells use HMR. ...

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