Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

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Recent Submissions

  • Amargant i Riera, Farners, 1990-; García, Désirée; Barragán, Montserrat; Vassena, Rita; Vernos, Isabelle, 1959- (Nature Research, 2018)
    Human fertilization and embryo development involve a wide range of critical processes that determine the successful development of a new organism. Although Assisted Reproduction Technologies (ART) may help solve infertility ...
  • Sao Emani, Carine; Williams, Monique J.; Van Helden, Paul D.; Taylor, Malcolm J.C.; Carolis, Carlo; Wiid, I.J.; Baker, Bienyameen (Nature Research, 2018)
    Mycothiol (MSH) and ergothioneine (ERG) are thiols able to compensate for each other to protect mycobacteria against oxidative stress. Gamma-glutamylcysteine (GGC), another thiol and an intermediate in ERG biosynthesis has ...
  • Jiménez Guri, Eva; Wotton, Karl R.; Jaeger, Johannes, 1973- (Royal Society, 2018)
    Gap genes are involved in segment determination during early development of the vinegar fly Drosophila melanogaster and other dipteran insects (flies, midges and mosquitoes). They are expressed in overlapping domains along ...
  • Saus Martínez, Ester; Willis, Jesse R.; Pryszcz, Leszek Piotr, 1985-; Hafez, Ahmed; Llorens, Carlos; Himmelbauer, Heinz; Gabaldón Estevan, Juan Antonio, 1973- (Cold Spring Harbor Laboratory Press (CSHL Press), 2018)
    RNA molecules play important roles in virtually every cellular process. These functions are often mediated through the adoption of specific structures that enable RNAs to interact with other molecules. Thus, determining ...
  • Coll, Olga; Guitart, Tanit; Villalba, Ana; Papin, Catherine; Simonelig, Martine; Gebauer, Fátima (Cold Spring Harbor Laboratory Press (CSHL Press), 2018)
    Cytoplasmic polyadenylation is a widespread mechanism to regulate mRNA translation. In vertebrates, this process requires two sequence elements in target 3' UTRs: the U-rich cytoplasmic polyadenylation element and the ...
  • Baloula, Vanessa; Fructuoso, Marta; Kassis, Nadim; Gueddouri, Dalale; Paul, Jean-Louis; Janel, Nathalie (Elsevier, 2018)
    Hyperhomocysteinemia due to cystathionine beta synthase (CBS) deficiency is associated with diverse cognitive dysfunction. Considering the role of the serine/threonine kinase DYRK1A, not only in developmental defects with ...
  • Kotlobay, Alexey A.; Marcet Houben, Marina; Gabaldón Estevan, Juan Antonio, 1973-; Yampolsky, Ilia V. (National Academy of Sciences, 2018)
    Bioluminescence is found across the entire tree of life, conferring a spectacular set of visually oriented functions from attracting mates to scaring off predators. Half a dozen different luciferins, molecules that emit ...
  • Chiva, Cristina; Olivella, Roger; Borràs, Eva; Espadas, Guadalupe; Pastor, Olga; Solé, Amanda; Sabidó Aguadé, Eduard, 1981- (Public Library of Science (PLoS), 2018)
    The increasing number of biomedical and translational applications in mass spectrometry-based proteomics poses new analytical challenges and raises the need for automated quality control systems. Despite previous efforts ...
  • Fernández, Juan Pablo; Moreno Mateos, Miguel Ángel; Gohr, André; Miao, Liyun; Chan, Shun Hang; Irimia, Manuel; Giraldez, Antonio J. (Public Library of Science (PLoS), 2018)
    Pre-mRNA splicing is a critical step of gene expression in eukaryotes. Transcriptome-wide splicing patterns are complex and primarily regulated by a diverse set of recognition elements and associated RNA-binding proteins. ...
  • Schmidt, David; Reuter, Hanna; Hüttner, Katja; Ruhe, Larissa; Rabert, Franziska; Seebeck, Florian; Irimia, Manuel; Solana, Jordi; Bartscherer, Kerstin (Public Library of Science (PLoS), 2018)
    In multicellular organisms, cell type diversity and fate depend on specific sets of transcript isoforms generated by post-transcriptional RNA processing. Here, we used Schmidtea mediterranea, a flatworm with extraordinary ...
  • Nir, Guy; Farabella, Irene; Soler-Vila, Paula; Martí Renom, Marc A.; Wu, C.-ting (Public Library of Science (PLoS), 2018)
    Chromosome organization is crucial for genome function. Here, we present a method for visualizing chromosomal DNA at super-resolution and then integrating Hi-C data to produce three-dimensional models of chromosome ...
  • Marin-Riera, Miquel; Moustakas-Verho, Jacqueline; Savriama, Yoland; Jernvall, Jukka; Salazar-Ciudad, Isaac (Public Library of Science (PLoS), 2018)
    From gastrulation to late organogenesis animal development involves many genetic and bio-mechanical interactions between epithelial and mesenchymal tissues. Ectodermal organs, such as hairs, feathers and teeth are well ...
  • Lozano Ortega, Marta; Valera, Gema; Xiao, Yan; Faucherre, Adèle; López-Schier, Hernán (Public Library of Science (PLoS), 2018)
    Directional mechanoreception by hair cells is transmitted to the brain via afferent neurons to enable postural control and rheotaxis. Neuronal tuning to individual directions of mechanical flow occurs when each peripheral ...
  • de Sousa, Nídia; Rodríguez Esteban, Gustavo; Rojo-Laguna, Jose Ignacio; Saló, Emili; Adell, Teresa (Public Library of Science (PLoS), 2018)
    The Hippo pathway plays a key role in regulating cell turnover in adult tissues, and abnormalities in this pathway are consistently associated with human cancers. Hippo was initially implicated in the control of cell ...
  • Naranjo Ortiz, Miguel Ángel, 1989-; Rodríguez-Píres, Silvia; Torres, Rosario; De Cal, Antonieta; Usall, Josep; Gabaldón Estevan, Juan Antonio, 1973- (American Society for Microbiology, 2018)
    Monilinia laxa (phylum Ascomycota) is a plant pathogen responsible for the brown rot blossom blight disease in stone fruit trees of the Rosaceae family, such as apricots. We report here the genome sequence of strain 8L of ...
  • Hernández Javier, Laura; Benzekri, Hicham; Gut, Marta; Claros, M. Gonzalo; van Bergeijk, Stefanie; Cañavate, José Pedro; Manchado, Manuel (Frontiers, 2018)
    Iodine metabolism is essential for the antioxidant defense of marine algae and in the biogeochemical cycle of iodine. Moreover, some microalgae can synthetize thyroid hormone-like compounds that are essential to sustain ...
  • Diego, Xavier; Marcon, Luciano, 1983-; Müller, Patrick; Sharpe, James (American Physical Society, 2018)
    Turing’s theory of pattern formation is a universal model for self-organization, applicable to many systems in physics, chemistry, and biology. Essential properties of a Turing system, such as the conditions for the existence ...
  • Verd Fernández, Berta, 1984-; Clark, Erik; Wotton, Karl R.; Janssens, Hilde; Jiménez Guri, Eva; Crombach, Anton; Jaeger, Johannes, 1973- (Public Library of Science (PLoS), 2018)
    Insects determine their body segments in two different ways. Short-germband insects, such as the flour beetle Tribolium castaneum, use a molecular clock to establish segments sequentially. In contrast, long-germband insects, ...
  • Slavkov, Ivica; Karcheska, Jana; Kocev, Dragi; Džeroski, Sašo (ComSIS Consortium, 2018)
    In machine learning, the growing complexity of the available data poses an increased challenge for its analysis. The rising complexity is both in terms of the data becoming more high-dimensional as well as the data having ...
  • Thompson, Rachel; Abicht, Angela; Beeson, David; Engel, Andrew G.; Eymard, Bruno; Maxime, Emmanuel; Lochmüller, Hanns (BioMed Central, 2018)
    Background: Congenital myasthenic syndromes (CMS) are a heterogeneous group of inherited neuromuscular disorders sharing the common feature of fatigable weakness due to defective neuromuscular transmission. Despite rapidly ...

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