Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

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Recent Submissions

  • Lichancová, Hana; Hodorová, Viktória; Sienkiewicz, Karolina; Penir, Sarah Mae U.; Afanasyev, Philipp; Boceck, Dominic; Bonnin, Sarah; Hakobyan, Siras; Krawczyk, Pawel S.; Smyczynska, Urszula; Zhivkoplias, Erik; Zlatohurska, Maryna; Odrzywolski, Adrian; Tralle, Eugeniusz; Frolova, Alina; Pryszcz, Leszek Piotr, 1985-; Brejová, Broňa; Vinař, Tomáš; Nosek, Jozef (American Society for Microbiology, 2019)
    Saprochaete suaveolens is an ascomycetous yeast that produces a range of fruity flavors and fragrances. Here, we report the high-contiguity genome sequence of the ex-holotype strain, NRRL Y-17571 (CBS 152.25). The nuclear ...
  • Courthéoux, Thibault; Reboutier, David; Vazeille, Thibaut; Cremet, Jean-Yves; Benaud, Christelle; Vernos, Isabelle, 1959-; Prigent, Claude (Company of Biologists, 2019)
    During mitosis, the cell sequentially constructs two microtubule-based spindles to ensure faithful segregation of chromosomes. A bipolar spindle first pulls apart the sister chromatids, then a central spindle further ...
  • Pinder, Corinne; Matsuo, Yuzy; Maurer, Sebastian; Toda, Takashi (Company of Biologists, 2019)
    High-fidelity chromosome segregation relies on proper microtubule regulation. Kinesin-8 has been shown to destabilise microtubules to reduce metaphase spindle length and chromosome movements in multiple species. XMAP215/chTOG ...
  • Bassaganyas Bars, Laia, 1985-; Popa, Stephanie J.; Horlbeck, Max; Puri, Claudia; Stewart, Sarah E.; Campelo, Felix; Ashok, Anupama, 1985-; Butnaru, Cristian M.; Brouwers, Nathalie; Heydari, Kartoosh; Ripoche, Jean; Weissman, Jonathan; Rubinsztein, David C.; Schekman, Randy; Malhotra, Vivek; Moreau, Kevin; Villeneuve, Julien (Rockefeller University Press, 2019)
    Protein and membrane trafficking pathways are critical for cell and tissue homeostasis. Traditional genetic and biochemical approaches have shed light on basic principles underlying these processes. However, the list of ...
  • Gu, Yuchen; Moroy, Gautier; Paul, Jean-Louis; Rebillat, Anne-Sophie; Dierssen, Mara; Torre Fornell, Rafael de la; Cieuta-Walti, Cécile; Dairou, Julien; Janel, Nathalie (MDPI, 2020)
    Epigallocatechin gallate (EGCG) is an inhibitor of DYRK1A, a serine/threonine kinase considered to be a major contributor of cognitive dysfunctions in Down syndrome (DS). Two clinical trials in adult patients with DS have ...
  • de Dios, Toni; van Dorp, Lucy; Charlier, Philippe; Morfopoulou, Sofia; Lizano, Esther; Bon, Celine; Le Bitouzé, Corinne; Alvarez-Estape, Marina; Marquès i Bonet, Tomàs, 1975-; Balloux, François; Lalueza Fox, Carles, 1965- (Elsevier, 2020)
    The French revolutionary Jean-Paul Marat (1743-1793) was assassinated in 1793 in his bathtub, where he was trying to find relief from the debilitating skin disease he was suffering from. At the time of his death, Marat was ...
  • Castellano Esteve, David; Eyre-Walker, Adam; Munch, Kasper (Oxford University Press, 2020)
    DNA diversity varies across the genome of many species. Variation in diversity across a genome might arise from regional variation in the mutation rate, variation in the intensity and mode of natural selection, and regional ...
  • Holland, Christian H.; Tanevski, Jovan; Perales-Patón, Javier; Gleixner, Jan; Kumar, Manu P.; Mereu, Elisabetta; Joughin, Brian A.; Stegle, Oliver; Lauffenburger, Douglas A.; Heyn, Holger; Szalai, Bence; Saez-Rodriguez, Julio (BioMed Central, 2020)
    BACKGROUND: Many functional analysis tools have been developed to extract functional and mechanistic insight from bulk transcriptome data. With the advent of single-cell RNA sequencing (scRNA-seq), it is in principle ...
  • Oury, Julien; Liu, Yun; Töpf, Ana; Todorovic, Slobodanka; Hoedt, Esthelle; Preethish-Kumar, Veeramani; Neubert, Thomas A.; Lin, Weichun; Lochmüller, Hanns; Burden, Steven J. (Rockefeller University Press, 2019)
    Complex mechanisms are required to form neuromuscular synapses, direct their subsequent maturation, and maintain the synapse throughout life. Transcriptional and post-translational pathways play important roles in synaptic ...
  • Signorelli, Mirko; Ayoglu, Burcu; Johansson, Camilla; Lochmüller, Hanns; Straub, Volker; Muntoni, Francesco; Niks, Erik; Tsonaka, Roula; Persson, Anja; Aartsma-Rus, Annemieke; Nilsson, Peter; Al-Khalili Szigyarto, Cristina; Spitali, Pietro (Wiley-VCH Verlag, 2019)
    BACKGROUND: Duchenne muscular dystrophy (DMD) is a fatal disease for which no cure is available. Clinical trials have shown to be largely underpowered due to inter-individual variability and noisy outcome measures. The ...
  • Cantarella, Simona; Carnevali, Davide; Morselli, Marco; Conti, Anastasia; Pellegrini, Matteo; Montanini, Barbara; Dieci, Giorgio (MDPI, 2019)
    Alu retroelements, whose retrotransposition requires prior transcription by RNA polymerase III to generate Alu RNAs, represent the most numerous non-coding RNA (ncRNA) gene family in the human genome. Alu transcription is ...
  • Pires Hartwig, Fernando; Dalmau Bueno, Albert; Guxens Junyent, Mònica; Bustamante Pineda, Mariona; Gomes Victora, Cesar (Oxford University Press, 2019)
    Background: Accumulating evidence suggests that breastfeeding benefits children’s intelligence, possibly due to long-chain polyunsaturated fatty acids (LC-PUFAs) present in breast milk. Under a nutritional adequacy hypothesis, ...
  • Quinn, Thomas P.; Erb, Ionas; Gloor, Greg; Notredame, Cedric; Richardson, Mark F.; Crowley, Tamsyn M. (Oxford University Press, 2019)
    Background: Next-generation sequencing (NGS) has made it possible to determine the sequence and relative abundance of all nucleotides in a biological or environmental sample. A cornerstone of NGS is the quantification of ...
  • Fernández Torras, Adrià; Duran-Frigola, Miquel, 1985-; Aloy, Patrick, 1972- (BioMed Central, 2019)
    Background: The integration of large-scale drug sensitivity screens and genome-wide experiments is changing the field of pharmacogenomics, revealing molecular determinants of drug response without the need for previous ...
  • McCartney, Ann M.; Hyland, Edel M.; Cormican, Paul; Moran, Raymond J.; Webb, Andrew E.; Lee, Kate D.; Hernández Rodríguez, Jéssica, 1983-; Prado Martínez, Javier, 1987-; Creevey, Christopher J.; Aspden, Julie L.; McInerney, James O.; Marquès i Bonet, Tomàs, 1975-; O'Connell, Mary J. (Oxford University Press, 2019)
    Gene fusion occurs when two or more individual genes with independent open reading frames becoming juxtaposed under the same open reading frame creating a new fused gene. A small number of gene fusions described in detail ...
  • Álvarez Campos, Patricia; Kenny, Nathan J.; Verdes, Aida; Fernández, Rosa; Novo, Marta; Giribet, Gonzalo; Riesgo, Ana (Oxford University Press, 2019)
    Stolonization in syllid annelids is a unique mode of reproduction among animals. During the breeding season, a structure resembling the adult but containing only gametes, called stolon, is formed generally at the posterior ...
  • Alioto, Tyler; Cruz, Fernando; Gómez Garrido, Jèssica; Triyatni, Miriam; Gut, Marta; Frias, Leonor; Esteve-Codina, Anna; Menne, Stephan; Kiialainen, Anna; Kumpesa, Nadine; Birzele, Fabian; Schmucki, Roland; Gut, Ivo Glynne; Spleiss, Olivia (Genetics Society of America, 2019)
    The Eastern woodchuck (Marmota monax) has been extensively used in research of chronic hepatitis B and liver cancer because its infection with the woodchuck hepatitis virus closely resembles a human hepatitis B virus ...
  • Mixão, Verónica; Saus Martínez, Ester; Perez Hansen, Antonio; Lass-Florl, Cornelia; Gabaldón Estevan, Juan Antonio, 1973- (Genetics Society of America, 2019)
    Infections caused by opportunistic yeast pathogens have increased over the last years. These infections can be originated by a large number of diverse yeast species of varying incidence, and with distinct clinically relevant ...
  • Iglesias, Valentin; Paladin, Lisanna; Juan Blanco, Teresa, 1989-; Pallarès, Irantzu; Aloy, Patrick, 1972-; Tosatto, Silvio C.E.; Ventura, Salvador (Frontiers, 2019)
    Prion-like behavior has been in the spotlight since it was first associated with the onset of mammalian neurodegenerative diseases. However, a growing body of evidence suggests that this mechanism could be behind the ...
  • Cuartero, Sergi; Innes, Andrew J.; Merkenschlager, Matthias (Frontiers, 2019)
    Classical driver mutations in acute myeloid leukemia (AML) typically affect regulators of cell proliferation, differentiation, and survival. The selective advantage of increased proliferation, improved survival, and reduced ...

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