Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

Col·leccions d'aquesta comunitat

Enviaments recents

  • Payer, Bernhard, 1975- (Elsevier, 2016)
    With the emergence of sex-determination by sex chromosomes, which differ in composition and number between males and females, appeared the need to equalize X-chromosomal gene dosage between the sexes. Mammals have devised ...
  • Hartasánchez Frenk, Diego Andrés, 1982-; Brasó-Vives, Marina; Fuentes-Díaz, Juanma; Vallés-Codina, Oriol; Navarro i Cuartiellas, Arcadi, 1969- (Oxford University Press, 2016)
    SUMMARY: SeDuS is the first flexible and user-friendly forward-in-time simulator of patterns of molecular evolution within segmental duplications undergoing interlocus gene conversion and crossover. SeDuS introduces known ...
  • Le Dily, François; Serra, François; Marti-Renom, Marc A. (Wiley, 2017)
    The genome is organized in a hierarchical fashion within the nucleus in interphase. This nonrandom folding of the chromatin fiber is thought to play important roles in the processing of the genetic information. Therefore, ...
  • Altimiras, Francisco; Uszczynska-Ratajczak, Barbara; Cámara, Francisco; Vlasova, Anna; Palumbo, Emilio; Newhouse, Stephen; Deacon, Robert M. J.; Farias, Leandro A. E.; Hurley, Michael J.; Loyola, David E.; Vásquez, Rodrigo A.; Dobson, Richard; Guigó Serra, Roderic; Cogram, Patricia (Frontiers, 2017)
  • Stojanovski, Klement; Ferrar, Tony; Benisty, Hannah; Uschner, Friedemann; Delgado, Javier; Jimenez, Javier; Solé, Carme; Nadal Clanchet, Eulàlia de; Klipp, Edda; Posas Garriga, Francesc; Serrano Pubull, Luis, 1982-; Kiel, Christina (Elsevier, 2017)
    The understanding of interaction dynamics in signaling pathways can shed light on pathway architecture and provide insights into targets for intervention. Here, we explored the relevance of kinetic rate constants of a key ...
  • Gaidt, Moritz M.; Ebert, Thomas S.; Chauhan, Dhruv; Schmidt, Tobias; Schmid-Burgk, Jonathan L.; Rapino, Francesca, 1982-; Robertson, Avril A. B.; Cooper, Matthew A.; Graf, T. (Thomas); Hornung, Veit (Elsevier, 2016)
    Interleukin-1β (IL-1β) is a cytokine whose bioactivity is controlled by activation of the inflammasome. However, in response to lipopolysaccharide, human monocytes secrete IL-1β independently of classical inflammasome ...
  • Supek, Fran; Škunca, Nieves (Springer, 2017)
    Contemporary techniques in biology produce readouts for large numbers of genes simultaneously, the typical example being differential gene expression measurements. Moreover, those genes are often richly annotated using GO ...
  • Plassais, Jocelyn; Lagoutte, Laetitia; Correard, Solenne; Paradis, Manon; Guaguère, Eric; Hédan, Benoit; Pommier, Alix; Botherel, Nadine; Cadiergues, Marie-Christine; Pilorge, Philippe; Silversides, David; Bizot, Maud; amuels, Mark; Arnan Ros, Carme; Johnson, Rory; Hitte, Christophe; Salbert, Gilles; Méreau, Agnès; Quignon, Pascale; Derrien, Thomas; André, Catherine (Public Library of Science (PLoS), 2016)
    Human Hereditary Sensory Autonomic Neuropathies (HSANs) are characterized by insensitivity to pain, sometimes combined with self-mutilation. Strikingly, several sporting dog breeds are particularly affected by such ...
  • Cavazza, Tommaso, 1985-; Malgaretti, Paolo; Vernos, Isabelle, 1959- (American Society for Cell Biology, 2016)
    Centrosome maturation is the process by which the duplicated centrosomes recruit pericentriolar components and increase their microtubule nucleation activity before mitosis. The role of this process in cells entering mitosis ...
  • Brbić, Maria; Piškorec, Martija; Vidulin, Vedrana; Kriško, Anita; Šmuc, Tomislav; Supek, Fran (Oxford University Press, 2016)
    Bacteria and Archaea display a variety of phenotypic traits and can adapt to diverse ecological niches. However, systematic annotation of prokaryotic phenotypes is lacking. We have therefore developed ProTraits, a resource ...
  • Lepeta, Katarzyna; Catuara-Solarz, Silvina; Seidenbecher, Constanze (Wiley, 2016)
    Synapses are essential components of neurons and allow information to travel coordinately throughout the nervous system to adjust behavior to environmental stimuli and to control body functions, memories, and emotions. ...
  • Morozumi, Yuichi; Gut, Marta; Khochbin, Saadi (Oxford University Press, 2016)
    Although the conserved AAA ATPase and bromodomain factor, ATAD2, has been described as a transcriptional co-activator upregulated in many cancers, its function remains poorly understood. Here, using a combination of ChIP-seq, ...
  • Lloréns Rico, Verónica, 1989-; Cano, Jaime; Kamminga, Tjerko; Gil, Rosario; Latorre, Amparo; Chen, Wei-Hua; Bork, Peer; Glass, John I.; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (American Association for the Advancement of Science (AAAS), 2016)
    cis-Encoded antisense RNAs (asRNAs) are widespread along bacterial transcriptomes. However, the role of most of these RNAs remains unknown, and there is an ongoing discussion as to what extent these transcripts are the ...
  • Senthivel, Vivek Raj; Sturrock, Marc; Piedrafita, Gabriel; Isalan, Mark (Nature Publishing Group, 2016)
    Nonlinear responses to signals are widespread natural phenomena that affect various cellular processes. Nonlinearity can be a desirable characteristic for engineering living organisms because it can lead to more switch-like ...
  • Erb, Ionas; Notredame, Cedric (Springer, 2016)
    Correlation is ubiquitously used in gene expression analysis although its validity as an objective criterion is often questionable. If no normalization reflecting the original mRNA counts in the cells is available, correlation ...
  • Marchese, Domenica, 1986; Sanchez de Groot, Natalia; Lorenzo Gotor, Maria de las Nieves; Livi, Carmen Maria; Tartaglia, Gian Gaetano (Wiley, 2016)
    From transcription, to transport, storage, and translation, RNA depends on association with different RNA-binding proteins (RBPs). Methods based on next-generation sequencing and protein mass-spectrometry have started to ...
  • Huerta Cepas, Jaime; Serra, François; Bork, Peer (Oxford University Press, 2016)
    The Environment for Tree Exploration (ETE) is a computational framework that simplifies the reconstruction, analysis, and visualization of phylogenetic trees and multiple sequence alignments. Here, we present ETE v3, ...
  • Sanges, Daniela; Simonte, Giacoma, 1984-; Di Vicino, Umberto; Romo Saladrigas, Neus, 1982-; Pinilla, Isabel; Nicolás, Marta; Cosma, Maria Pia, 1970- (American Society for Clinical Investigation, 2016)
    Vision impairments and blindness caused by retinitis pigmentosa result from severe neurodegeneration that leads to a loss of photoreceptors, the specialized light-sensitive neurons that enable vision. Although the mammalian ...
  • Santos, António J. M.; Durkin, Charlotte H.; Helaine, Sophie; Boucrot, Emmanuel; Holden, David W. (American Society for Microbiology, 2016)
    Several bacterial pathogens and viruses interfere with the cell cycle of their host cells to enhance virulence. This is especially apparent in bacteria that colonize the gut epithelium, where inhibition of the cell cycle ...
  • Paul, Dirk S.; Heath, Simon; Gut, Marta; Gut, Ivo Glynne; Leslie, R. David (Nature Publishing Group, 2016)
    The incidence of type 1 diabetes (T1D) has substantially increased over the past decade, suggesting a role for non-genetic factors such as epigenetic mechanisms in disease development. Here we present an epigenome-wide ...

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