Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

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Recent Submissions

  • Gopalakrishnan, Shyam; Montero, Marc de Manuel; Kuderna, Lukas F.K.; Serres Armero, Aitor; González-Basallote, Víctor Manuel; Marquès i Bonet, Tomàs, 1975-; Gilbert, M Thomas (Elsevier, 2018)
    The evolutionary history of the wolf-like canids of the genus Canis has been heavily debated, especially regarding the number of distinct species and their relationships at the population and species level [1-6]. We assembled ...
  • Iacono, Giovanni; Mereu, Elisabetta; Guillaumet-Adkins, Amy; Corominas, Roser; Cuscó Martí, Ivon, 1973-; Rodríguez Esteban, Gustavo; Gut, Marta; Pérez Jurado, Luis Alberto; Gut, Ivo Glynne; Heyn, Holger (Cold Spring Harbor Laboratory Press (CSHL Press), 2018)
    Single-cell RNA sequencing (scRNA-seq) has significantly deepened our insights into complex tissues, with the latest techniques capable of processing tens of thousands of cells simultaneously. Analyzing increasing numbers ...
  • Vizcaya-Molina, Elena; Klein, Cecilia C.; Serras Rigalt, Florenci; Mishra, Rakesh K.; Guigó Serra, Roderic; Corominas Guiu, Montserrat (Cold Spring Harbor Laboratory Press (CSHL Press), 2018)
    One of the most important questions in regenerative biology is to unveil how and when genes change expression and trigger regeneration programs. The resetting of gene expression patterns during response to injury is governed ...
  • Lorente-Galdós, Belén, 1981-; Lao Grueso, Oscar, 1976-; Serra Vidal, Gerard, 1989-; Santpere Baró, Gabriel, 1981-; Kuderna, Lukas F.K.; Arauna, Lara R; Fadhlaoui-Zid, Karima; Pimenoff, Ville N.; Soodyall, Himla; Zalloua, Pierre A.; Marquès i Bonet, Tomàs, 1975-; Comas, David, 1969- (BioMed Central, 2019)
    Background: Population demography and gene flow among African groups, as well as the putative archaic introgression of ancient hominins, have been poorly explored at the genome level. Results: Here, we examine 15 African ...
  • Torre Fornell, Rafael de la; De Sola Llopis, Susana; Xicota Vila, Laura, 1987-; Cuenca Royo, Aida Ma, 1981-; Rodriguez, Joan; Gomis González, Maria; Hernández, Gimena; Del Hoyo Soriano, Laura; Ozaita Mintegui, Andrés, 1969-; Dierssen, Mara; TESXF Study Group; Principe, Alessandro; Espadaler, Josep María; Roca, Laia; Del Hoyo Soriano, Laura; Farré Albaladejo, Magí; Fitó Colomer, Montserrat; León Jorba, Alba; Banea, Ovideo; Maldonado, Rafael, 1961-; Busquets Garcia, Arnau, 1985- (Elsevier, 2019)
    Background & aims: Despite the wide spectrum of experimental compounds tested in clinical trials, there is still no proven pharmacological treatment available for Fragile-X syndrome (FXS), since several targeted clinical ...
  • Garrido-Martín, Diego; Palumbo, Emilio; Guigó Serra, Roderic; Breschi, Alessandra, 1988- (Public Library of Science (PLoS), 2018)
    We present ggsashimi, a command-line tool for the visualization of splicing events across multiple samples. Given a specified genomic region, ggsashimi creates sashimi plots for individual RNA-seq experiments as well as ...
  • Guigó Serra, Roderic; de Hoon, Michiel (F1000Research, 2018)
    At the beginning of this century, the Human Genome Project produced the first drafts of the human genome sequence. Following this, large-scale functional genomics studies were initiated to understand the molecular basis ...
  • Gohr, André; Irimia, Manuel (Oxford University Press, 2019)
    Summary: Tracking thousands of alternative splicing (AS) events genome-wide makes their downstream analysis computationally challenging and laborious. Here, we present Matt, the first UNIX command-line toolkit with focus ...
  • Ricci, Maria Aurelia, 1985-; Cosma, Maria Pia, 1970-; Lakadamyali, Melike (Elsevier, 2017)
    Chromatin fiber organization is essential for gene function in all cell types. Moreover it helps to determine cell fate in embryonic/adult stem cells and in somatic cells undergoing reprogramming to pluripotency. Until now ...
  • Puente, Xosé S.; Escaramís, Geòrgia; Bassaganyas Bars, Laia, 1985-; Tubio, José M. C.; Tornador Antolin, Cristian, 1979-; Himmelbauer, Heinz; Castillo Andreo, Esther; Dohm, Juliane C.; Guigó Serra, Roderic; Estivill, Xavier, 1955-; Campo, Elias (Nature Research, 2011)
    Chronic lymphocytic leukaemia (CLL), the most frequent leukaemia in adults in Western countries, is a heterogeneous disease with variable clinical presentation and evolution. Two major molecular subtypes can be distinguished, ...
  • Taal, H. Rob; Guxens Junyent, Mònica; Sunyer Deu, Jordi; Estivill, Xavier, 1955-; Jaddoe, Vincent W. V. (Nature Research, 2012)
    To identify genetic variants associated with head circumference in infancy, we performed a meta-analysis of seven genome-wide association studies (GWAS) (N = 10,768 individuals of European ancestry enrolled in pregnancy ...
  • Lagarde, Julien; Uszczynska-Ratajczak, Barbara; Carbonell, Silvia; Pérez-Lluch, Sílvia; Davis, Carrie A.; Gingeras, Thomas R.; Frankish, Adam; Harrow, Jennifer; Guigó Serra, Roderic; Johnson, Rory (Nature Research, 2017)
    Accurate annotation of genes and their transcripts is a foundation of genomics, but currently no annotation technique combines throughput and accuracy. As a result, reference gene collections remain incomplete-many gene ...
  • Ardlie, Kristin G.; Guigó Serra, Roderic (Elsevier, 2017)
    Characterizing and interpreting the function of the millions of genetic variants in the human genome is a pressing need in medical and evolutionary genomics and is fundamental to understanding the molecular, cellular, and ...
  • Angiolini, Francesca; Irimia, Manuel; Chigna, Claudia (eLife, 2019)
    The biological players involved in angiogenesis are only partially defined. Here, we report that endothelial cells (ECs) express a novel isoform of the cell-surface adhesion molecule L1CAM, termed L1-ΔTM. The splicing ...
  • The STAR consortium; Guigó Serra, Roderic; López Bigas, Núria; Shikhagaie, Medya; Hubner, Norbert (Nature Research, 2008)
    The laboratory rat is one of the most extensively studied model organisms. Inbred laboratory rat strains originated from limited Rattus norvegicus founder populations, and the inherited genetic variation provides an excellent ...
  • Zanzoni, Andreas; Spinelli, Lionel; Ribeiro, Diogo M.; Tartaglia, Gian Gaetano; Brun, Christine (Nature Research, 2019)
    The coordination of the synthesis of functionally-related proteins can be achieved at the post-transcriptional level by the action of common regulatory molecules, such as RNA-binding proteins (RBPs). Despite advances in ...
  • Rabionet, Raquel; Remesal, Agustín; Mensa Vilaró, Anna; Murías, Sara; Alcobendas, Rosa; González-Roca, Eva; Ruíz Ortiz, Estíbaliz; Antón, Jordi; Iglesias, Estibaliz; Modesto, Consuelo; Comas, David, 1969-; Puig, Anna; Drechsel, Oliver; Ossowski, Stephan; Yagüe, Jordi L.; Merino, Rosa; Estivill, Xavier, 1955-; Aróstegui, Juan Ignacio (Nature Research, 2019)
    Juvenile idiopathic arthritis (JIA) is a complex rheumatic disease with both autoimmune and autoinflammatory components. Recently, familial cases of systemic-onset JIA have been attributed to mutations in LACC1/FAMIN. We ...
  • Julià, Antonio; Bonàs-Guarch, Silvia; Mercader Bigas, Josep Maria; Torrents, David; Fernández-Nebro, Antonio (BioMed Central, 2018)
    Background: Systemic lupus erythematosus (SLE) is a common systemic autoimmune disease with a complex genetic inheritance. Genome-wide association studies (GWAS) have significantly increased the number of significant loci ...
  • Alemany-Navarro, María; Costas, Javier; Real, Eva; Segalàs, Cinto; Bertolín, Sara; Domènech Salgado, Laura, 1989-; Rabionet, Raquel; Carracedo, Ángel; Menchón, José M.; Alonso, Pino (Nature Research, 2019)
    The rate of response to pharmacological treatment in Obsessive-compulsive disorder (OCD) oscillates between 40 and 70%. Genetic and environmental factors have been associated with treatment response in OCD. This study ...
  • di Domenico, Angelique; Carola, Giulia; Calatayud, Carles; Pons Espinal, Meritxell, 1986-; Muñoz, Juan Pablo; Richaud Patin, Yvonne; Fernández Carasa, Irene; Gut, Marta; Faella, Armida; Parameswaran, Janani, 1990-; Soriano, Jordi; Ferrer, Isidre; Tolosa, Eduard; Zorzano, Antonio; Cuervo, Ana Maria; Raya Chamorro, Ángel; Consiglio, Antonella (Elsevier, 2019)
    Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminergic neurons (vmDAns) and the accumulation of toxic α-synuclein. A non-cell-autonomous contribution, in particular of astrocytes, ...

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