Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

Collections in this community

Recent Submissions

  • Pegueroles Queralt, Maria Cinta; Iraola Guzman, Susana; Chorostecki, Uciel; Ksiezopolska, Ewa; Saus Martínez, Ester; Gabaldón Estevan, Juan Antonio, 1973- (Taylor & Francis, 2019)
    Long non-coding RNAs (lncRNAs) are a heterogeneous class of genes that do not code for proteins. Since lncRNAs (or a fraction thereof) are expected to be functional, many efforts have been dedicated to catalog lncRNAs in ...
  • Raote, Ishier; Malhotra, Vivek (Rockefeller University Press, 2019)
    Palade's corpus placed small vesicles as the sole means to transport proteins across stable distinct compartments of the secretory pathway. We suggest that cargo, spatial organization of secretory compartments, and the ...
  • Thompson, Rachel; Bonne, Gisèle; Missier, Paolo; Lochmüller, Hanns (Portland Press, 2019)
    Despite recent scientific advances, most rare genetic diseases - including most neuro-muscular diseases - do not currently have curative gene-based therapies available. However, in some cases, such as vitamin, cofactor or ...
  • Germann, Philipp; Marin-Riera, Miquel; Sharpe, James (Elsevier, 2019)
    Simulating morphogenesis of both mesenchyme and epithelium has typically required complex and computationally expensive models. To meet this challenge, we developed ya||a-yet another parallel agent-based model. Our model ...
  • Weghorn, Donate; Balick, Daniel J.; Cassa, Christopher; Kosmicki, Jack A.; Daly, Mark J.; Beier, David R.; Sunyaev, Shamil R. (Oxford University Press, 2019)
    The fate of alleles in the human population is believed to be highly affected by the stochastic force of genetic drift. Estimation of the strength of natural selection in humans generally necessitates a careful modeling ...
  • Schmiedel, Jörn M.; Carey, Lucas; Lehner, Ben, 1978- (Nature Research, 2019)
    The effects of cell-to-cell variation (noise) in gene expression have proven difficult to quantify because of the mechanistic coupling of noise to mean expression. To independently quantify the effects of changes in mean ...
  • Chiva, Cristina; Pastor, Olga; Trilla Fuertes, Lucía; Gámez Pozo, Angelo; Fresno Vara, Juan Ángel; Sabidó Aguadé, Eduard, 1981- (American Chemical Society (ACS), 2019)
    Targeted proteomics has become the method of choice for biomarker validation in human biopsies due to its high sensitivity, reproducibility, accuracy, and precision. However, for targeted proteomics to be transferred to ...
  • Guerrero Jijon, Santiago Xavier; López Cortés, Andrés; García-Cárdenas, Jennyfer M.; Saa, Pablo; Indacochea Cusirramos, Alberto; Armendáriz-Castillo, Isaac; Zambrano, Ana Karina; Yumiceba, Verónica; Pérez-Villa, Andy; Guevara-Ramírez, Patricia; Moscoso-Zea, Oswaldo; Paredes, Joel; Leone, Paola E.; Paz-y-Miño, César (Public Library of Science (PLoS), 2019)
    Scientific data recording and reporting systems are of a great interest for endorsing reproducibility and transparency practices among the scientific community. Current research generates large datasets that can no longer ...
  • Gruzieva, Olena; Kogevinas, Manolis; Ruiz, José L.; Bustamante Pineda, Mariona; Antó i Boqué, Josep Maria; Sunyer Deu, Jordi; Vrijheid, Martine; Hernandez-Ferrer, Carles, 1987-; Melén, Erik (National Institute of Environmental Health Sciences (NIEHS), 2019)
    BACKGROUND: Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes. OBJECTIVES: We aimed ...
  • Pedragosa Marín, Mireia, 1988-; Riera Domínguez, María Graciela, 1987-; Casella, Valentina; Esteve-Codina, Anna; Steuerman, Yael; Seth, Celina; Bocharov, Gennady A.; Heath, Simon; Gat-Viks, Irit; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Frontiers Media, 2019)
    The host immune response against infection requires the coordinated action of many diverse cell subsets that dynamically adapt to a pathogen threat. Due to the complexity of such a response, most immunological studies have ...
  • Guiducci, Giulia; Paone, Alessio; Tramonti, Angela; Giardina, Giorgio; Rinaldo, Serena; Bouzidi, Amani; Magnifico, Maria C.; Marani, Marina; Menendez, Javier A.; Fatica, Alessandro; Macone, Alberto; Armaos, Alexandros; Tartaglia, Gian Gaetano; Contestabile, Roberto; Paiardini, Alessandro; Cutruzzolà, Francesca (Oxford University Press, 2019)
    Enzymes of intermediary metabolism are often reported to have moonlighting functions as RNA-binding proteins and have regulatory roles beyond their primary activities. Human serine hydroxymethyltransferase (SHMT) is essential ...
  • Ji, Yun; Di Croce, Luciano; Gattinoni, Luca (Nature Research, 2019)
    T cell senescence and exhaustion are major barriers to successful cancer immunotherapy. Here we show that miR-155 increases CD8+ T cell antitumor function by restraining T cell senescence and functional exhaustion through ...
  • Agraz-Doblas, Antonio; Bueno, Clara; Bashford-Rogers, Rachael; Roy, Anindita; Schneider, Pauline; Bardini, Michela; Ballerini, Paola; Cazzaniga, Gianni; Moreno, Thaidy; Revilla, Carlos; Gut, Marta; Valsecchi, Maria G.; Roberts, Irene; Pieters, Rob; De Lorenzo, Paola; Varela, Ignacio; Menéndez, Pablo; Stam, Ronald W. (Ferrata Storti Foundation, 2019)
    B-cell acute lymphoblastic leukemia is the commonest childhood cancer. In infants, B-cell acute lymphoblastic leukemia remains fatal, especially in patients with t(4;11), present in ~80% of cases. The pathogenesis of ...
  • D'Angelo, Arturo; Dierkes, Kai; Carolis, Carlo; Salbreux, Guillaume; Solon, Jérôme (Elsevier, 2019)
    During development, cell-generated forces induce tissue-scale deformations to shape the organism [1,2]. The pattern and extent of these deformations depend not solely on the temporal and spatial profile of the generated ...
  • Torres Méndez, Antonio; Bonnal, Sophie; Marquez, Yamile; Roth, Jonathan; Iglesias, Marta; Permanyer, Jon; Almudí, Isabel; O'Hanlon, Dave; Guitart, Tanit; Soller, Matthias; Gingras, Anne-Claude; Gebauer, Fátima; Rentzsch, Fabian; Blencowe, Benjamin J.; Valcárcel, J. (Juan); Irimia, Manuel (Nature Research, 2019)
    The mechanisms by which entire programmes of gene regulation emerged during evolution are poorly understood. Neuronal microexons represent the most conserved class of alternative splicing in vertebrates, and are critical ...
  • Chiritoiu, Marioara; Brouwers, Nathalie; Turacchio, Gabriele; Pirozzi, Marianella; Malhotra, Vivek (Elsevier, 2019)
    Signal-sequence-lacking interleukin (IL)-1β, is cleaved by caspase-1 to mature mIL-1β, which is secreted, without entering the endoplasmic reticulum. We report that macrophages of GRASP55-/- mice are defective in mIL-1β ...
  • Amargant i Riera, Farners, 1990-; Barragan, Montserrat; Vassena, Rita; Vernos, Isabelle, 1959- (Oxford University Press, 2019)
    Microtubules are intracellular filaments that define in space and in time a large number of essential cellular functions such as cell division, morphology and motility, intracellular transport and flagella and cilia assembly. ...
  • Marigorta, Urko M.; Rodríguez, Juan Antonio; Gibson, Greg; Navarro i Cuartiellas, Arcadi, 1969- (Elsevier, 2018)
    Since the publication of the Wellcome Trust Case Control Consortium (WTCCC) landmark study a decade ago, genome-wide association studies (GWAS) have led to the discovery of thousands of risk variants involved in disease ...
  • Olesti Muñoz, Eulàlia, 1991-; De Toma, Ilario; Ramaekers, Johannes G.; Brunt, Tibor M.; Carbó Banús, Marcel·lí; Fernández-Avilés, Cristina; Robledo, Patricia, 1958-; Farré Albaladejo, Magí; Dierssen, Mara; Pozo Mendoza, Óscar J.; Torre Fornell, Rafael de la (SAGE Publications, 2019)
    BACKGROUND: The unprecedented proliferation of new psychoactive substances (NPS) threatens public health and challenges drug policy. Information on NPS pharmacology and toxicity is, in most cases, unavailable or very limited ...
  • Roewenstrunk, Julia Maria, 1981-; Di Vona, Chiara, 1981-; Chen, Jie; Borràs, Eva; Dong, Chao; Arató, Krisztina, 1981-; Sabidó Aguadé, Eduard, 1981-; Huen, Michael S. Y.; Luna Gargantilla, Susana de la (Nature Research, 2019)
    Dysregulation of the DYRK1A protein kinase has been associated with human disease. On the one hand, its overexpression in trisomy 21 has been linked to certain pathological traits of Down syndrome, while on the other, ...

View more