Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

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Recent Submissions

  • Hollmann, Nele Merret; Jagtap, Pravin Kumar Ankush; Masiewicz, Pawel; Guitart, Tanit; Simon, Bernd; Provaznik, Jan; Stein, Frank; Haberkant, Per; Sweetapple, Lara Jayne; Villacorta, Laura; Mooijman, Dylan; Benes, Vladimir; Savitski, Mikhail M.; Gebauer, Fátima; Hennig, Janosch (Elsevier, 2020)
    RNA-binding proteins (RBPs) commonly feature multiple RNA-binding domains (RBDs), which provide these proteins with a modular architecture. Accumulating evidence supports that RBP architectural modularity and adaptability ...
  • Rea, Jessica; Menci, Valentina; Tollis, Paolo; Santini, Tiziana; Armaos, Alexandros, 1989-; Garone, Maria Giovanna; Iberite, Federica; Cipriano, Andrea; Tartaglia, Gian Gaetano; Rosa, Alessandro; Ballarino, Monica; Laneve, Pietro; Caffarelli, Elisa (Nature Research, 2020)
    Neuronal differentiation is a timely and spatially regulated process, relying on precisely orchestrated gene expression control. The sequential activation/repression of genes driving cell fate specification is achieved by ...
  • Boni, Jacopo; Rubio Pérez, Carlota, 1990-; López Bigas, Núria; Fillat i Fonts, Cristina; Luna, Susana de la (MDPI, 2020)
    DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic factors that phosphorylate a broad set of ...
  • Pérez Soriano, Alexandra; Arnal, Magdalena; Botta Orfila, Teresa; Giraldo, Darly; Fernández, Manel; Compta, Yaroslau; Fernández-Santiago, Ruben; Ezquerra, Mario; Tartaglia, Gian Gaetano; Martí, M. Josep; Catalan multiple system atrophy-registry (CMSAR) (Nature Research, 2020)
    Background: Multiple system atrophy (MSA) is a rare oligodendroglial synucleinopathy of unknown etiopathogenesis including two major clinical variants with predominant parkinsonism (MSA-P) or cerebellar dysfunction (MSA-C). ...
  • Blanco Cabra, Núria; Paetzold, Bernhard, 1981-; Ferrar, Tony; Mazzolini, Rocco; Torrents, Eduard; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (Nature Research, 2020)
    Aggregates of Pseudomonas aeruginosa form a protective barrier against antibiotics and the immune system. These barriers, known as biofilms, are associated with several infectious diseases. One of the main components of ...
  • Vansant, Gerlinde; Chen, Heng-Chang; Zorita, Eduard; Trejbalová, Katerina; Miklík, Dalibor; Filion, Guillaume; Debyser, Zeger (Oxford University Press, 2020)
    HIV-1 persists lifelong in memory cells of the immune system as latent provirus that rebounds upon treatment interruption. Therefore, the latent reservoir is the main target for an HIV cure. Here, we studied the direct ...
  • Reim, Alexander; Ackermann, Roland; Font Mateu, Jofre, 1977-; Kammel, Robert; Beato, Miguel; Nolte, Stefan; Mann, Matthias; Russmann, Christoph; Wierer, Michael, 1982- (Nature Research, 2020)
    Transcription factors (TFs) regulate target genes by specific interactions with DNA sequences. Detecting and understanding these interactions at the molecular level is of fundamental importance in biological and clinical ...
  • Toda, Haruka; Borràs, Eva; Sabidó Aguadé, Eduard, 1981-; del Portillo, Hernando A. (Nature Research, 2020)
    Plasmodium vivax is the most widely distributed human malaria parasite. Previous studies have shown that circulating microparticles during P. vivax acute attacks are indirectly associated with severity. Extracellular ...
  • Alriquet, Marion; Calloni, Giulia; Martínez Limón, Adrián; Delli Ponti, Riccardo, 1987-; Hanspach, Gerd; Hegensbach, Martin; Tartaglia, Gian Gaetano; Vabulas, R. Martin (Oxford University Press (OUP), 2020)
    Post-transcriptional methylation of N6- and N1-adenine can effect transcriptome turnover and translation. Furthermore, the regulatory function of N6-methyladenine (m6A) during heat shock has been uncovered, including the ...
  • Begik, Oguzhan; Lucas, Morghan C.; Liu, Huanle; Ramírez, José Miguel; Mattick, John S.; Novoa, Eva Maria (BioMed Central, 2020)
    Background: RNA modifications play central roles in cellular fate and differentiation. However, the machinery responsible for placing, removing, and recognizing more than 170 RNA modifications remains largely uncharacterized ...
  • Massoni-Badosa, Ramon; Iacono, Giovanni; Moutinho, Catia; Kulis, Marta; Palau, Núria; Marchese, Domenica, 1986-; Rodríguez Ubreva, Javier; Ballestar, Esteban; Rodríguez Esteban, Gustavo; Marsal, Sara; Aymerich, Marta; Colomer, Dolors; Campo, Elias; Julià Cano, Antoni; Martín-Subero, José I.; Heyn, Holger (BioMed Central, 2020)
    Robust protocols and automation now enable large-scale single-cell RNA and ATAC sequencing experiments and their application on biobank and clinical cohorts. However, technical biases introduced during sample acquisition ...
  • Hovhannisyan, Hrant; Saus Martínez, Ester; Ksiezopolska, Ewa; Roberts, Alex J. Hinks; Louis, Edward J.; Gabaldón Estevan, Juan Antonio (Frontiers Media, 2020)
    The formation of interspecific hybrids results in the coexistence of two diverged genomes within the same nucleus. It has been hypothesized that negative epistatic interactions and regulatory interferences between the two ...
  • Schiffer, Jodie A.; Servello, Francesco A.; Heath, William R.; Amrit, Francis Raj Ghandi; Stumbur, Stephanie V; Eder, Matthias; Martin, Olivier M. F.; Johnsen, Sean B.; Stanley, Julia A.; Tam, Hannah; Brennan, Sara J.; McGowan, Natalie G.; Vogelaar, Abigail L.; Xu, Yuyan; Serkin, William T.; Ghazi, Arjumand; Stroustrup, Nicholas; Apfeld, Javier (eLife, 2020)
    Hydrogen peroxide is the preeminent chemical weapon that organisms use for combat. Individual cells rely on conserved defenses to prevent and repair peroxide-induced damage, but whether similar defenses might be coordinated ...
  • Palomero, Luis; Mereu, Elisabetta; Pujana, Miguel Angel (Elsevier, 2020)
    Proper immune system function hinders cancer development, but little is known about whether genetic variants linked to cancer risk alter immune cells. Here, we report 57 cancer risk loci associated with differences in ...
  • Díaz Garrido, Natalia; Bonnin, Sarah; Riera-Borrull, Marta; Giménez, Rosa; Badia, Josefa; Baldomà, Laura (MDPI, 2020)
    The interconnection between nutrients, metabolites and microbes is a key factor governing the healthy/pathological status of an individual. Thus, microbiota-based research is essential in order to better understand human ...
  • Montero-Blay, Ariadna; Piñero-Lambea, Carlos; Miravet Verde, Samuel; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Elsevier, 2020)
    Here, we propose an approach to identify active metabolic pathways by integrating gene essentiality analysis and protein abundance. We use two bacterial species (Mycoplasma pneumoniae and Mycoplasma agalactiae) that share ...
  • Matalonga, Leslie; Laurie, Steven; Papakonstantinou, Anastasios; Piscia, Davide; Mereu, Elisabetta; Bullich, Gemma; Thompson, Rachel; Horvath, Rita; Pérez Jurado, Luis Alberto; Riess, Olaf; Gut, Ivo; van Ommen, Gert-Jan; Lochmüller, Hanns; Beltran, Sergi; RD–Connect Genome-Phenome Analysis Platform and URD-Cat Data Contributors (Elsevier, 2020)
    Autozygosity is associated with an increased risk of genetic rare disease, thus being a relevant factor for clinical genetic studies. More than 2400 exome sequencing data sets were analyzed and screened for autozygosity ...
  • Milà Alomà, Marta; Salvadó, Gemma; Gispert López, Juan Domingo; Vilor Tejedor, Natàlia, 1988-; Grau-Rivera, Oriol; Sala Vila, Aleix; Sánchez Benavides, Gonzalo; Arenaza Urquijo, Eider M.; Crous-Bou, Marta; González de Echávarri, José Maria; Minguillón, Carolina; Fauria, Karine; Simon, Maryline; Kollmorgen, Gwendlyn; Zetterberg, Henrik; Blennow, Kaj; Suárez-Calvet, Marc; Molinuevo, José Luis; ALFA Study (Wiley, 2020)
    Introduction: The biological pathways involved in the preclinical stage of the Alzheimer's continuum are not well understood. Methods: We used NeuroToolKit and Elecsys® immunoassays to measure cerebrospinal fluid (CSF) ...
  • Piñero-Lambea, Carlos; García Ramallo, Eva; Martínez, Sira; Delgado, Javier; Serrano Pubull, Luis, 1982-; Lluch-Senar, Maria 1982- (American Chemical Society (ACS), 2020)
    Mycoplasma species share a set of features, such as lack of a cell wall, streamlined genomes, simplified metabolism, and the use of a deviant genetic code, that make them attractive approximations of what a chassis strain ...
  • Consolati, Tanja; Locke, Julia; Roostalu, Johanna; Chen, Zhuo Angel; Gannon, Julian; Asthana, Jayant; Lim, Wei Ming; Martino, Fabrizio; Cvetkovic, Milos A.; Rappsilber, Juri; Costa, Alessandro; Surrey, Thomas (Elsevier, 2020)
    The γ-tubulin ring complex (γTuRC) is the major microtubule nucleator in cells. The mechanism of its regulation is not understood. We purified human γTuRC and measured its nucleation properties in a total internal reflection ...

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