Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

Col·leccions d'aquesta comunitat

Enviaments recents

  • Feichtinger, Julia; Hernández, Inmaculada; Fischer, Christoph; Hanscho, Michael; Auer, Norbert; Hackl, Matthias; Jadhav, Vaibhav; Baumann, Martina; Krempl, Peter M.; Schmidl, Christian; Farlik, Matthias; Schuster, Michael; Merkel, Angelika; Sommer, Andreas; Heath, Simon; Rico, Daniel; Bock, Christoph; Thallinger, Gerhard R.; Borth, Nicole (Wiley, 2016)
    The most striking characteristic of CHO cells is their adaptability, which enables efficient production of proteins as well as growth under a variety of culture conditions, but also results in genomic and phenotypic ...
  • Cuscó Pons, Pol; Filion, Guillaume (Oxford University Press, 2016)
    Motivation: Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) is the standard method to investigate chromatin protein composition. As the number of community-available ChIP-seq profiles ...
  • Buzdugan, Laura; Kalisch, Markus; Navarro i Cuartiellas, Arcadi, 1969-; Schunk, Daniel; Fehr, Ernst; Bühlmann, Peter (2016)
    Motivation: Although Genome Wide Association Studies (GWAS) genotype a very large number of single nucleotide polymorphisms (SNPs), the data are often analyzed one SNP at a time. The low predictive power of single SNPs, ...
  • Campbell, Matthew A.; Ganley, Austen R. D.; Gabaldón Estevan, Juan Antonio, 1973-; Cox, Murray P. (University of Chicago Press, 2016)
    Polyploidy—the increase in the number of whole chromosome sets—is an important evolutionary force in eukaryotes. Polyploidy is well recognized throughout the evolutionary history of plants and animals, where several ancient ...
  • Joubert, Bonnie R.; Salas Díaz, Lucas Andrés, 1980-; Ruiz, Carlos; Bustamante Pineda, Mariona; Gonzalez, Juan Ramon; Pinart, Mariona; Guerra, Stefano; Vrijheid, Martine; Antó i Boqué, Josep Maria; Sunyer Deu, Jordi; London, Stephanie J. (Elsevier, 2016)
    Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child ...
  • Pérez Vilaró, Gemma, 1985-; Fernández-Carrillo, Carlos; Mensa, Laura; Miquel, Rosa; Sanjuan, Xavier; Forns, Xavier; Pérez del Pulgar, Sofía; Díez Antón, Juana, 1962- (Elsevier, 2015)
    BACKGROUND & AIMS: Decoding the myriad of interactions that hepatitis C virus (HCV) establishes with infected cells is mandatory to obtain a complete understanding of HCV biology and its associated pathogenesis. We and ...
  • The MetaSUB International Consortium; Ossowski, Stephan; Bezdan, Daniela (BioMed Central, 2016)
    The Metagenomics and Metadesign of the Subways and Urban Biomes (MetaSUB) International Consortium is a novel, interdisciplinary initiative comprised of experts across many fields, including genomics, data analysis, ...
  • Quilez Oliete, Javier; Guilmatre, Audrey; Garg, Paras; Highnam, Gareth; Gymrek, Melissa; Erlich, Yaniv; Joshi, Ricky S.; Mittelman, David; Sharp, Andrew J. (Oxford University Press, 2016)
    Despite representing an important source of genetic variation, tandem repeats (TRs) remain poorly studied due to technical difficulties. We hypothesized that TRs can operate as expression (eQTLs) and methylation (mQTLs) ...
  • Martinez, Xavier; Pozuelo, Marta; Pascal, Victoria; Campos, David; Gut, Ivo Glynne; Gut, Marta; Azpiroz, Fernando; Guarner, Francisco; Manichanh, Chaysavanh (Nature Publishing Group, 2016)
    To date, meta-omic approaches use high-throughput sequencing technologies, which produce a huge amount of data, thus challenging modern computers. Here we present MetaTrans, an efficient open-source pipeline to analyze the ...
  • Lobanov, Michail Yu.; Klus,Petr, 1985-; Sokolovsky, Igor V.; Tartaglia, Gian Gaetano; Galzitskaya, Oxana V. (Nature Publishing Group, 2016)
    The biological function of multiple repetitions of single amino acids, or homo-repeats, is largely unknown, but their occurrence in proteins has been associated with more than 20 hereditary diseases. Analysing 122 bacterial ...
  • Ferreira, Pedro G.; Oti, Martin; Barann, Matthias; Wieland, Thomas; Ezquina, Suzana; Friedländer, Marc R.; Rivas, Manuel A.; Esteve-Codina, Anna; The GEUVADIS Consortium; Rosenstiel, Philip; Strom, Tim M.; Lappalainen, Tuuli; Guigó Serra, Roderic; Sammeth, Michael (Nature Publishing Group, 2016)
    Recent advances in the cost-efficiency of sequencing technologies enabled the combined DNA- and RNA-sequencing of human individuals at the population-scale, making genome-wide investigations of the inter-individual genetic ...
  • Deri, Batel; Kanteev, Margarita; Goldfeder, Mor; Lecina, Daniel; Guallar i Tasies, Víctor; Adir, Noam; Fishman, Ayelet (Nature Publishing Group, 2016)
    Tyrosinases are responsible for melanin formation in all life domains. Tyrosinase inhibitors are used for the prevention of severe skin diseases, in skin-whitening creams and to avoid fruit browning, however continued use ...
  • Sottile, Francesco; Aulicino, Francesco, 1987-; Theka, Ilda; Cosma, Maria Pia, 1970- (Nature Publishing Group, 2016)
    Homotypic and heterotypic cell-to-cell fusion are key processes during development and tissue regeneration. Nevertheless, aberrant cell fusion can contribute to tumour initiation and metastasis. Additionally, a form of ...
  • Saint-Léger, Adélaïde; Bello Cabrera, Carla; Dans, Pablo D.; Gabriel Torres, Adrian; Novoa, Eva Maria; Camacho, Noelia; Orozco, Modesto; Kondrashov, Fyodor A., 1979-; Ribas de Pouplana, Lluís (American Association for the Advancement of Science (AAAS), 2016)
    Understanding the principles that led to the current complexity of the genetic code is a central question in evolution. Expansion of the genetic code required the selection of new transfer RNAs (tRNAs) with specific ...
  • Guerrero Jijon, Santiago Xavier; Dujardin, Gwendal; Cabrera-Andrade, Alejandro; Paz-y-Miño, César; Indacochea Cusirramos, Alberto; Inglés Ferrándiz, Marta; Nadimpalli, Hima Priyanka; Collu, Nicola; Dublanche, Yann; De Mingo Benítez, Ismael; Camargo, David (Public Library of Science (PLoS), 2016)
    Electronic laboratory notebooks (ELNs) will probably replace paper laboratory notebooks (PLNs) in academic research due to their advantages in data recording, sharing and security. Despite several reports describing technical ...
  • Ramírez-Estrada, Karla; Altabella, Teresa; Onrubia Ibáñez, Miriam, 1982-; Moyano Claramunt, Elisabet; Notredame, Cedric; Osuna, Lidia; Vanden Bossche, Robin; Goossens, Alain; Cusidó Vidal, Rosa M.; Palazón, Javier (2016)
    Plant cell cultures constitute eco-friendly biotechnological platforms for the production of plant secondary metabolites with pharmacological activities, as well as a suitable system for extending our knowledge of secondary ...
  • Burgess, Selena G.; Oleksy, Arkadiusz; Cavazza, Tommaso, 1985-; Richards, Mark W.; Vernos, Isabelle, 1959-; Matthews, David; Bayliss, Richard (Royal Society, 2016)
    The vast majority of clinically approved protein kinase inhibitors target the ATP-binding pocket directly. Consequently, many inhibitors have broad selectivity profiles and most have significant off-target effects. Allosteric ...
  • Furió-Tarí, Pedro; Tarazona, Sonia; Gabaldón Estevan, Juan Antonio, 1973-; Enright, Anton J.; Conesa, Ana (Oxford University Press, 2016)
    Non-coding RNA transcripts such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs) are important genetic regulators. However, the functions of many of these transcripts are still not clearly understood. Recently, it ...
  • Floden, Evan Wade; Tommaso, Paolo Di; Chatzou, Maria; Magis, Cedrik; Notredame, Cedric; Chang, Jia-Ming, 1978- (Oxford University Press, 2016)
    The PSI/TM-Coffee web server performs multiple sequence alignment (MSA) of proteins by combining homology extension with a consistency based alignment approach. Homology extension is performed with Position Specific Iterative ...
  • Pryszcz, Leszek Piotr, 1985-; Gabaldón Estevan, Juan Antonio, 1973- (Oxford University Press, 2016)
    Many genomes display high levels of heterozygosity (i.e. presence of different alleles at the same loci in homologous chromosomes), being those of hybrid organisms an extreme such case. The assembly of highly heterozygous ...

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