Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

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Recent Submissions

  • García-Moreno, Fernando; Anderton, Edward; Jankowska, Marta; Begbie, Jo; Encinas, Juan Manuel; Irimia, Manuel; Molnár, Zoltán (Elsevier, 2018)
    Several neuronal populations orchestrate neocortical development during mammalian embryogenesis. These include the glutamatergic subplate-, Cajal-Retzius-, and ventral pallium-derived populations, which coordinate cortical ...
  • Couto Alves, Alexessander; Estivill, Xavier, 1955-; Sunyer Deu, Jordi; Early Growth Genetics (EGG) Consortium (American Association for the Advancement of Science (AAAS), 2019)
    Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of ...
  • Tollis, Marc; Robbins, Jooke; Webb, Andrew E.; Kuderna, Lukas F.K.; Caulin, Aleah F.; Garcia, Jacinda D.; Bèrubè, Martine; Pourmand, Nader; Marquès i Bonet, Tomàs, 1975-; O'Connell, Mary J.; Palsbøll, Per J.; Maley, Carlo C. (Oxford University Press, 2019)
    Cetaceans are a clade of highly specialized aquatic mammals that include the largest animals that have ever lived. The largest whales can have ∼1,000× more cells than a human, with long lifespans, leaving them theoretically ...
  • Grassi, Luigi; Ullrich, Sebastian, 1984-; Merkel, Angelika; Gut, Marta; Heath, Simon; Gut, Ivo Glynne; Kuijpers, Taco W. (Elsevier, 2018)
    Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing ...
  • Wettmarshausen, Jennifer; Goh, Valerie; Huang, Kai-Ting; Arduino, Daniela M.; Tripathi, Utkarsh; Leimpek, Anja; Cheng, Yiming; Pittis, Alexandros, 1982-; Gabaldón Estevan, Juan Antonio, 1973-; Mokranjac, Dejana; Hajnóczky, György; Perocchi, Fabiana (Elsevier, 2018)
    The mitochondrial calcium uniporter is a highly selective ion channel composed of species- and tissue-specific subunits. However, the functional role of each component still remains unclear. Here, we establish a synthetic ...
  • Horiuchi, Keiko; Papasaikas, Panagiotis; Valcárcel, J. (Juan); Gutiérrez-Adán, Alfonso (Elsevier, 2018)
    The U2AF35-like ZRSR1 has been implicated in the recognition of 3' splice site during spliceosome assembly, but ZRSR1 knockout mice do not show abnormal phenotypes. To analyze ZRSR1 function and its precise role in RNA ...
  • Cid-Samper, Fernando; Gelabert-Baldrich, Mariona; Lang, Benjamin; Lorenzo Gotor, Maria de las Nieves; Ponti, Riccardo delli; Severijnen, Lies-Anne W.F.M.; Bolognesi, Benedetta; Gelpi, Ellen; Hukema, Renate K.; Botta Orfila, Teresa; Tartaglia, Gian Gaetano (Elsevier, 2018)
    Recent evidence indicates that specific RNAs promote the formation of ribonucleoprotein condensates by acting as scaffolds for RNA-binding proteins (RBPs). We systematically investigated RNA-RBP interaction networks to ...
  • Besray Unal, E.; Kiel, Christina; Benisty, Hannah; Campbell, Andrew; Pickering, Karen; Blüthgen, Nils; Sansom, Owen J.; Serrano Pubull, Luis, 1982- (BioMed Central, 2018)
    Background: Proteins of the ubiquitously expressed core proteome are quantitatively correlated across multiple eukaryotic species. In addition, it was found that many protein paralogues exhibit expression anticorrelation, ...
  • Malta, Tathiane M.; Heyn, Holger; Wiznerowicz, Maciej (Elsevier, 2018)
    Cancer progression involves the gradual loss of a differentiated phenotype and acquisition of progenitor and stem-cell-like features. Here, we provide novel stemness indices for assessing the degree of oncogenic ...
  • Qamar, Seema; Tartaglia, Gian Gaetano; St George-Hyslop, Peter (Elsevier, 2018)
    Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free organelles and is, in part, driven by the intrinsically disordered low-complexity (LC) domain of FUS. Here, we ...
  • Colomer Montañà, Carlota, 1990-; Margalef González, Pol, 1985-; Villanueva, Alberto; Vert, Anna; Pecharroman, Irene; Solé, Laura; González-Farré, Mónica; Alonso, Josune; Montagut Viladot, Clara; Martínez Iniesta, María; Bertran, Joan; Borràs, Eva; Iglesias, Mar; Sabidó Aguadé, Eduard, 1981-; Bigas Salvans, Anna; Boulton, Simon J.; Espinosa Blay, Lluís (Elsevier, 2019)
    Phosphorylated IKKalpha(p45) is a nuclear active form of the IKKalpha kinase that is induced by the MAP kinases BRAF and TAK1 and promotes tumor growth independent of canonical NF-¿B signaling. Insights into the sources ...
  • Verde, Gaetano; De Llobet, Lara Isabel; Wright, Roni H.G.; Quilez Oliete, Javier; Peiró Sales, Sandra; Le Dily, François; Beato, Miguel (MDPI, 2018)
    Breast cancer prognosis and response to endocrine therapy strongly depends on the expression of the estrogen and progesterone receptors (ER and PR, respectively). Although much is known about ERα gene (ESR1) regulation ...
  • Villamor, Judith; Ramos-Barbero, María Dolores; González-Torres, Pedro; Gabaldón Estevan, Juan Antonio, 1973-; Rosselló-Mora, Ramón; Meseguer, Inmaculada; Martínez García, Manuel; Santos, Fernando; Antón, Josefa (Nature Research, 2018)
    Hypersaline environments close to saturation harbor the highest density of virus-like particles reported for aquatic systems as well as low microbial diversity. Thus, they offer unique settings for studying virus-host ...
  • Yus, Eva; Lloréns Rico, Verónica, 1989-; Martínez, Sira; Gallo López, Carolina, 1984-; Eilers, Hinnerk; Blötz, Cedric; Stülke, Jörg; Lluch-Senar, Maria 1982-; Serrano Pubull, Luis, 1982- (Elsevier, 2019)
    Here, we determined the relative importance of different transcriptional mechanisms in the genome-reduced bacterium Mycoplasma pneumoniae, by employing an array of experimental techniques under multiple genetic and ...
  • Naranjo Ortiz, Miguel Ángel, 1989-; Gabaldón Estevan, Juan Antonio, 1973- (Wiley, 2019)
    Fungi are a highly diverse group of heterotrophic eukaryotes characterized by the absence of phagotrophy and the presence of a chitinous cell wall. While unicellular fungi are far from rare, part of the evolutionary success ...
  • Miotto, Mattia; Olimpieri, Pier Paolo; Di Rienzo, Lorenzo; Ambrosetti, Francesco; Corsi, Pietro; Lepore, Rosalba; Tartaglia, Gian Gaetano; Milanetti, Edoardo (Oxford University Press, 2019)
    Motivation: Understanding the molecular mechanisms of thermal stability is a challenge in protein biology. Indeed, knowing the temperature at which proteins are stable has important theoretical implications, which are ...
  • Balboa, Diego; Prasad, Rashmi B.; Groop, Leif; Otonkoski, Timo (Springer, 2019)
    Understanding the molecular mechanisms behind beta cell dysfunction is essential for the development of effective and specific approaches for diabetes care and prevention. Physiological human beta cell models are needed ...
  • Tirier, Stephan M.; Park, Jeongbin; Preußer, Friedrich; Amrhein, Lisa; Gu, Zuguang; Steiger, Simon; Mallm, Jan-Philipp; Krieger, Teresa; Waschow, Marcel; Eismann, Björn; Gut, Marta; Gut, Ivo Glynne; Rippe, Karsten; Schlesner, Matthias; Theis, Fabian; Fuchs, Christiane; Ball, Claudia R.; Glimm, Hanno; Eils, Roland; Conrad, Christian (Nature Research, 2019)
    Patient-derived 3D cell culture systems are currently advancing cancer research since they potentiate the molecular analysis of tissue-like properties and drug response under well-defined conditions. However, our understanding ...
  • Molnar, Cristina; Heinen, Jan Peter; Reina, José; Llamazares, Salud; Palumbo, Emilio; Breschi, Alessandra, 1988-; Gay, Marina; Villarreal, Laura; Vilaseca, Marta; Pollarolo, Giulia; González, Cayetano (American Association for the Advancement of Science (AAAS), 2019)
    The notable male predominance across many human cancer types remains unexplained. Here, we show that Drosophila l(3)mbt brain tumors are more invasive and develop as malignant neoplasms more often in males than in females. ...
  • Keiper, Sandra; Papasaikas, Panagiotis; Will, Cindy L.; Valcárcel, J. (Juan); Girard, Cyrille; Lüchrmann, Reinhard (Nature Research, 2019)
    Human pre-catalytic spliceosomes contain several proteins that associate transiently just prior to spliceosome activation and are absent in yeast, suggesting that this critical step is more complex in higher eukaryotes. ...

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