Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

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Recent Submissions

  • Goodstadt, Mike N.; Martí Renom, Marc A. (Elsevier, 2019)
    Genome discoveries at the core of biology are made by visual description and exploration of the cell, from microscopic sketches and biochemical mapping to computational analysis and spatial modeling. We outline the ...
  • Rosas Salvans, Miquel, 1987-; Scrofani, Jacopo, 1984-; Modol, Aitor; Vernos, Isabelle, 1959- (Company of Biologists, 2019)
    Bipolar spindle organization is essential for the faithful segregation of chromosomes during cell division. This organization relies on the collective activities of motor proteins. The minus-end-directed dynein motor complex ...
  • Ogando, Jesús; Sáez, María Eugenia; Santos, Javier; Nuevo-Tapioles, Cristina; Gut, Marta; Esteve-Codina, Anna; Heath, Simon; González-Pérez, Antonio; Cuezva, José M.; Lacalle, Rosa Ana; Mañes, Santos (BioMed Central, 2019)
    Background: Binding of the programmed death-1 (PD-1) receptor to its ligands (PD-L1/2) transduces inhibitory signals that promote exhaustion of activated T cells. Blockade of the PD-1 pathway is widely used for cancer ...
  • Roman-Canal, Berta; Tarragona, Jordi; Moiola, Cristian Pablo; Gatius, Sònia; Bonnin, Sarah; Ruiz-Miró, Maria; Sierra, José Enrique; Rufas, Maria; González, Esperanza; Porcel, José M.; Gil-Moreno, Antonio; Falcón-Pérez, Juan M.; Ponomarenko, Julia; Matias-Guiu, Xavier; Colas, Eva (BioMed Central, 2019)
    Background: Colorectal cancer (CRC) is the third leading cause of cancer-related mortality worldwide. Current systematic methods for diagnosing have inherent limitations so development of a minimally-invasive diagnosis, ...
  • Iacono, Giovanni; Massoni-Badosa, Ramon; Heyn, Holger (BioMed Central, 2019)
    Background: Single-cell RNA sequencing (scRNA-seq) plays a pivotal role in our understanding of cellular heterogeneity. Current analytical workflows are driven by categorizing principles that consider cells as individual ...
  • Hitte, Christophe; Le Béguec, Céline; Cadieu, Edouard; Wucher, Valentin; Primot, Aline; Prouteau, Anaïs; Botherel, Nadine; Hédan, Benoit; Lindblad-Toh, Kerstin; André, Catherine; Derrien, Thomas (MDPI, 2019)
    Mucosal melanomas (MM) are rare aggressive cancers in humans, and one of the most common forms of oral cancers in dogs. Similar biological and histological features are shared between MM in both species, making dogs a ...
  • Mallol, Anna; Guirola, Maria; Payer, Bernhard, 1975- (BioMed Central, 2019)
    Background: In order to prepare the genome for gametogenesis, primordial germ cells (PGCs) undergo extensive epigenetic reprogramming during migration toward the gonads in mammalian embryos. This includes changes on a ...
  • Cuadrado, Ana; Giménez-Llorente, Daniel; Kojic, Aleksandar; Rodríguez-Corsino, Miriam; Cuartero, Yasmina; Martín-Serrano, Guillermo; Gómez López, Gonzalo; Marti-Renom, Marc A.; Losada, Ana (Elsevier, 2019)
    Cohesin exists in two variants carrying either STAG/SA1 or SA2. Here we have addressed their specific contributions to the unique spatial organization of the mouse embryonic stem cell genome, which ensures super-enhancer-dependent ...
  • Roman-Canal, Berta; Pablo-Moiola, Cristian; Gatius, Sònia; Bonnin, Sarah; Ruiz-Miró, Maria; González, Esperanza; González-Tallada, Xavier; Llordella, Ivanna; Hernández, Isabel; Porcel, José M.; Gil-Moreno, Antonio; Falcón-Pérez, Juan M.; Ponomarenko, Julia; Matias-Guiu, Xavier; Colas, Eva (MDPI, 2019)
    Endometrial cancer (EC) is the sixth most common cancer in women worldwide and is responsible for more than 89,000 deaths every year. Mortality is associated with presence of poor prognostic factors at diagnosis, i.e., ...
  • Pegueroles Queralt, Maria Cinta; Iraola Guzman, Susana; Chorostecki, Uciel; Ksiezopolska, Ewa; Saus Martínez, Ester; Gabaldón Estevan, Juan Antonio, 1973- (Taylor & Francis, 2019)
    Long non-coding RNAs (lncRNAs) are a heterogeneous class of genes that do not code for proteins. Since lncRNAs (or a fraction thereof) are expected to be functional, many efforts have been dedicated to catalog lncRNAs in ...
  • Raote, Ishier; Malhotra, Vivek (Rockefeller University Press, 2019)
    Palade's corpus placed small vesicles as the sole means to transport proteins across stable distinct compartments of the secretory pathway. We suggest that cargo, spatial organization of secretory compartments, and the ...
  • Thompson, Rachel; Bonne, Gisèle; Missier, Paolo; Lochmüller, Hanns (Portland Press, 2019)
    Despite recent scientific advances, most rare genetic diseases - including most neuro-muscular diseases - do not currently have curative gene-based therapies available. However, in some cases, such as vitamin, cofactor or ...
  • Germann, Philipp; Marin-Riera, Miquel; Sharpe, James (Elsevier, 2019)
    Simulating morphogenesis of both mesenchyme and epithelium has typically required complex and computationally expensive models. To meet this challenge, we developed ya||a-yet another parallel agent-based model. Our model ...
  • Weghorn, Donate; Balick, Daniel J.; Cassa, Christopher; Kosmicki, Jack A.; Daly, Mark J.; Beier, David R.; Sunyaev, Shamil R. (Oxford University Press, 2019)
    The fate of alleles in the human population is believed to be highly affected by the stochastic force of genetic drift. Estimation of the strength of natural selection in humans generally necessitates a careful modeling ...
  • Schmiedel, Jörn M.; Carey, Lucas; Lehner, Ben, 1978- (Nature Research, 2019)
    The effects of cell-to-cell variation (noise) in gene expression have proven difficult to quantify because of the mechanistic coupling of noise to mean expression. To independently quantify the effects of changes in mean ...
  • Chiva, Cristina; Pastor, Olga; Trilla Fuertes, Lucía; Gámez Pozo, Angelo; Fresno Vara, Juan Ángel; Sabidó Aguadé, Eduard, 1981- (American Chemical Society (ACS), 2019)
    Targeted proteomics has become the method of choice for biomarker validation in human biopsies due to its high sensitivity, reproducibility, accuracy, and precision. However, for targeted proteomics to be transferred to ...
  • Guerrero Jijon, Santiago Xavier; López Cortés, Andrés; García-Cárdenas, Jennyfer M.; Saa, Pablo; Indacochea Cusirramos, Alberto; Armendáriz-Castillo, Isaac; Zambrano, Ana Karina; Yumiceba, Verónica; Pérez-Villa, Andy; Guevara-Ramírez, Patricia; Moscoso-Zea, Oswaldo; Paredes, Joel; Leone, Paola E.; Paz-y-Miño, César (Public Library of Science (PLoS), 2019)
    Scientific data recording and reporting systems are of a great interest for endorsing reproducibility and transparency practices among the scientific community. Current research generates large datasets that can no longer ...
  • Gruzieva, Olena; Kogevinas, Manolis; Ruiz, José L.; Bustamante Pineda, Mariona; Antó i Boqué, Josep Maria; Sunyer Deu, Jordi; Vrijheid, Martine; Hernandez-Ferrer, Carles, 1987-; Melén, Erik (National Institute of Environmental Health Sciences (NIEHS), 2019)
    BACKGROUND: Prenatal exposure to air pollution has been associated with childhood respiratory disease and other adverse outcomes. Epigenetics is a suggested link between exposures and health outcomes. OBJECTIVES: We aimed ...
  • Pedragosa Marín, Mireia, 1988-; Riera Domínguez, María Graciela, 1987-; Casella, Valentina; Esteve-Codina, Anna; Steuerman, Yael; Seth, Celina; Bocharov, Gennady A.; Heath, Simon; Gat-Viks, Irit; Argilaguet Marqués, Jordi, 1977-; Meyerhans, Andreas (Frontiers Media, 2019)
    The host immune response against infection requires the coordinated action of many diverse cell subsets that dynamically adapt to a pathogen threat. Due to the complexity of such a response, most immunological studies have ...
  • Guiducci, Giulia; Paone, Alessio; Tramonti, Angela; Giardina, Giorgio; Rinaldo, Serena; Bouzidi, Amani; Magnifico, Maria C.; Marani, Marina; Menendez, Javier A.; Fatica, Alessandro; Macone, Alberto; Armaos, Alexandros; Tartaglia, Gian Gaetano; Contestabile, Roberto; Paiardini, Alessandro; Cutruzzolà, Francesca (Oxford University Press, 2019)
    Enzymes of intermediary metabolism are often reported to have moonlighting functions as RNA-binding proteins and have regulatory roles beyond their primary activities. Human serine hydroxymethyltransferase (SHMT) is essential ...

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