Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

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Recent Submissions

  • Goya Grocin, Andrea; Serwa, Remigiusz A.; Morales Sanfrutos, Julia; Ritzefeld, Markus; Tate, Edward W. (American Society for Biochemistry and Molecular Biology (ASBMB), 2019)
    N-myristoylation is the covalent addition of a 14-carbon saturated fatty acid (myristate) to the N-terminal glycine of specific protein substrates by N-myristoyltransferase (NMT) and plays an important role in protein ...
  • Cabrera Pérez, Raquel; Monguió Tortajada, Marta; Gámez Valero, Ana; Rojas Márquez, Raquel; Borràs, Francesc Enric; Roura, Santiago; Vives, Joaquim (BioMed Central, 2019)
    Background: Orthopaedic diseases are one of the major targets for regenerative medicine. In this context, Wharton’s jelly (WJ) is an alternative source to bone marrow (BM) for allogeneic transplantation since its isolation ...
  • Hagolani, Pascal F.; Zimm, Roland; Marin-Riera, Miquel; Salazar-Ciudad, Isaac (Company of Biologists, 2019)
    Embryonic development involves gene networks, extracellular signaling, cell behaviors (cell division, adhesion, etc.) and mechanical interactions. How should these be coordinated to lead to complex and robust morphologies? ...
  • Clemente Batalha Pardal, Diana, 1990-; Maitre, Léa; Bustamante Pineda, Mariona; Chatzi, Leda; Roumeliotaki, Theano; Fossati, Serena; Grazuleviciene, Regina; Gützkow, Kristine B.; Lepeule, Johanna; Martens, Dries S.; McEachan, Rosemary R.C.; Meltzer, Helle Margrete; Petraviciene, Inga; Slama, Rémy; Tamayo-Uria, Ibon; Urquiza, José M.; Vafeiadi, Marina, 1983-; Wright, John; Nawrot, Tim S.; Vrijheid, Martine (Nature Research, 2019)
    Telomere length is considered a biomarker of biological aging. Shorter telomeres and obesity have both been associated with age-related diseases. To evaluate the association between various indices of obesity with leukocyte ...
  • Piedra Aguilera, Álvaro; Jiao, Chen; Luna, Ana P.; Villanueva, Francisco; Dabad, Marc; Esteve-Codina, Anna; Díaz Pendón, Juan A.; Fei, Zhangjun; Bejarano, Eduardo R.; Castillo, Araceli G. (Nature Research, 2019)
    Geminiviruses are plant ssDNA viruses that replicate through dsDNA intermediates and form minichromosomes which carry the same epigenetic marks as the host chromatin. During the infection, geminiviruses are targets of the ...
  • Thun, Gian Andri; Derdak, Sophia; Castro Giner, Francesc; Apunte Ramos, Katherine; Águeda, Lidia; Gut, Marta; Gut, Ivo Glynne (Nature Research, 2019)
    Chronic obstructive pulmonary disease (COPD) is induced by cigarette smoking and characterized by inflammation of airway tissue. Since smokers with COPD have a higher risk of developing lung cancer than those without, we ...
  • Roman-Canal, Berta; Moiola, Cristian Pablo; Gatius, Sònia; Bonnin, Sarah; Ruiz-Miró, Maria; González, Esperanza; Ojanguren, Amaia; Recuero, José Luis; Gil-Moreno, Antonio; Falcón-Pérez, Juan M.; Ponomarenko, Julia; Porcel, José M.; Matias-Guiu, Xavier; Colas, Eva (Nature Research, 2019)
    Lung cancer is the leading cause of cancer-related deaths among men and women in the world, accounting for the 25% of cancer mortality. Early diagnosis is an unmet clinical issue. In this work, we focused to develop a novel ...
  • Pedrotti, Simona; Caccia, Roberta; Neguembor, Maria Victoria; García Manteiga, José Manuel; Ferri, Giulia; Palma, Clara de; Canu, Tamara; Giovarelli, Matteo; Marra, Paolo; Fiocchi, Amleto; Molineris, Ivan; Raso, Michele; Sanvito, Francesca; Doglioni, Claudio; Esposito, Antonio; Clementi, Emilio; Gabellini, Davide (American Association for the Advancement of Science (AAAS), 2019)
    Obesity and its associated metabolic abnormalities have become a global emergency with considerable morbidity and mortality. Epidemiologic and animal model data suggest an epigenetic contribution to obesity. Nevertheless, ...
  • Frade, João; Nakagawa, Shoma; Cortes, Paola; Di Vicino, Umberto; Romo Saladrigas, Neus, 1982-; Lluis Viñas, Frederic; Cosma, Maria Pia, 1970- (American Association for the Advancement of Science (AAAS), 2019)
    Cells with high ploidy content are common in mammalian extraembryonic and adult tissues. Cell-to-cell fusion generates polyploid cells during mammalian development and tissue regeneration. However, whether increased ploidy ...
  • Delgado Blanco, Javier; Radusky, Leandro; Cianferoni, Damiano; Serrano Pubull, Luis, 1982- (National Academy of Sciences, 2019)
    RNA-protein interactions are crucial for such key biological processes as regulation of transcription, splicing, translation, and gene silencing, among many others. Knowing where an RNA molecule interacts with a target ...
  • Serrat Farran, Xènia, 1993-; Kukhtar, Dmytro; Cornes Maragliano, Eric, 1987-; Esteve-Codina, Anna; Benlloch, Helena; Cecere, Germano; Cerón Madrigal, Julián (Public Library of Science (PLoS), 2019)
    SF3B1 is the most frequently mutated splicing factor in cancer. Mutations in SF3B1 likely confer clonal advantages to cancer cells but they may also confer vulnerabilities that can be therapeutically targeted. SF3B1 cancer ...
  • Stobbe, Miranda D.; Thun, Gian Andri; Diéguez Docampo, Andrea; Oliva, Meritxell; Whalley, Justin P.; Raineri, Emanuele; Gut, Ivo Glynne (Public Library of Science (PLoS), 2019)
    The sheer size of the human genome makes it improbable that identical somatic mutations at the exact same position are observed in multiple tumours solely by chance. The scarcity of cancer driver mutations also precludes ...
  • Çubut, Cankut; Hidalgo, Marta R.; Amadoz, Alicia; Rian, Kinza; Salavert, Francisco; Pujana, Miguel Angel; Mateo, Francesca; Herranz Ors, Carmen, 1992-; Carbonell-Caballero, Jose; Dopazo, Joaquín (Nature Research, 2019)
    In spite of the increasing availability of genomic and transcriptomic data, there is still a gap between the detection of perturbations in gene expression and the understanding of their contribution to the molecular ...
  • Schiavinato, Matteo; Marcet Houben, Marina; Dohm, Juliane C.; Gabaldón Estevan, Juan Antonio, 1973-; Himmelbauer, Heinz (Wiley-Blackwell, 2019)
    Nicotiana section Suaveolentes is an almost all-Australian clade of allopolyploid tobacco species including the important plant model Nicotiana benthamiana. The homology relationships of this clade and its formation are ...
  • López Escardó, David, 1988-; Grau Bové, Xavier; Guillaumet-Adkins, Amy; Gut, Marta; Sieracki, Michael E.; Ruiz Trillo, Iñaki (Royal Society, 2019)
    Understanding the origins of animal multicellularity is a fundamental biological question. Recent genome data have unravelled the role that co-option of pre-existing genes played in the origin of animals. However, there ...
  • Ogara, Maria F.; Rodríguez Seguí, Santiago A.; Marini, Melisa; Silvina Nacht, Ana; Stortz, Martin; Levi, Valeria; Presman, Diego M.; Vicent, Guillermo Pablo; Pecci, Adali (Oxford University Press, 2019)
    The glucocorticoid and progesterone receptors (GR and PR) are closely related members of the steroid receptor family. Despite sharing similar structural and functional characteristics; the cognate hormones display very ...
  • Otterstrom, Jason; Castells García, Àlvaro, 1991-; Vicario, Chiara; Gómez García, Pablo; Cosma, Maria Pia, 1970-; Lakadamyali, Melike (Oxford University Press, 2019)
    Chromatin organization is crucial for regulating gene expression. Previously, we showed that nucleosomes form groups, termed clutches. Clutch size correlated with the pluripotency grade of mouse embryonic stem cells and ...
  • Buitrago, Diana; Codó, Laia; Illa, Ricard; Jorge, Pau de; Battistini, Federica; Flores, Oscar; Bayarri, Genis; Royo, Romina; Pino, Marc del; Heath, Simon; Hospital, Adam; Gelpí, Josep Lluís; Brun-Heath, Isabelle; Orozco, Modesto (Oxford University Press, 2019)
    We present Nucleosome Dynamics, a suite of programs integrated into a virtual research environment and created to define nucleosome architecture and dynamics from noisy experimental data. The package allows both the ...
  • Pogoryelova, Oksana; Wilson, Ian J.; Mansbach, Hank; Argov, Zohar; Nishino, Ichizo; Lochmüller, Hanns (Wolters Kluwer (LWW), 2019)
    Objective: To test the hypothesis that common GNE mutations influence disease severity; using statistical analysis of patient cohorts from different countries. Methods: Systematic literature review identified 11 articles ...
  • Bolognesi, Benedetta; Faure, Andre J.; Seuma, Mireia; Schmiedel, Jörn M.; Tartaglia, Gian Gaetano; Lehner, Ben, 1978- (Nature Research, 2019)
    Insoluble protein aggregates are the hallmarks of many neurodegenerative diseases. For example, aggregates of TDP-43 occur in nearly all cases of amyotrophic lateral sclerosis (ALS). However, whether aggregates cause ...

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