Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

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Recent Submissions

  • Olesti Muñoz, Eulàlia, 1991-; De Toma, Ilario; Ramaekers, Johannes G.; Brunt, Tibor M.; Carbó Banús, Marcel·lí; Fernández-Avilés, Cristina; Robledo, Patricia, 1958-; Farré Albaladejo, Magí; Dierssen, Mara; Pozo Mendoza, Óscar J.; Torre Fornell, Rafael de la (SAGE Publications, 2019)
    BACKGROUND: The unprecedented proliferation of new psychoactive substances (NPS) threatens public health and challenges drug policy. Information on NPS pharmacology and toxicity is, in most cases, unavailable or very limited ...
  • Roewenstrunk, Julia Maria, 1981-; Di Vona, Chiara, 1981-; Chen, Jie; Borràs, Eva; Dong, Chao; Arató, Krisztina, 1981-; Sabidó Aguadé, Eduard, 1981-; Huen, Michael S. Y.; Luna Gargantilla, Susana de la (Nature Research, 2019)
    Dysregulation of the DYRK1A protein kinase has been associated with human disease. On the one hand, its overexpression in trisomy 21 has been linked to certain pathological traits of Down syndrome, while on the other, ...
  • Horvath, Attila; Daniel, Bence; Szeles, Lajos; Cuaranta-Monroy, Ixchelt; Czimmerer, Zsolt; Ozgyin, Lilla; Steiner, Laszlo; Kiss, Mate; Simandi, Zoltan; Poliska, Szilard; Giannakis, Nikolas; Raineri, Emanuele; Gut, Ivo Glynne; Nagy, Benedek; Nagy, Laszlo (Oxford University Press, 2019)
    The concept of tissue-specific gene expression posits that lineage-determining transcription factors (LDTFs) determine the open chromatin profile of a cell via collaborative binding, providing molecular beacons to ...
  • Spill, Yannick G.; Castillo Andreo, David; Vidal, Enrique; Marti-Renom, Marc A. (Nature Research, 2019)
    Chromosome conformation capture techniques, such as Hi-C, are fundamental in characterizing genome organization. These methods have revealed several genomic features, such as chromatin loops, whose disruption can have ...
  • Sanchez de Groot, Natalia; Torrent, Marc; Ravarani, Charles N.J.; Trusina, Ala; Ventura, Salvador; Babu, M. Madan (Wiley-VCH Verlag, 2019)
    Phase separation of soluble proteins into insoluble deposits is associated with numerous diseases. However, protein deposits can also function as membrane-less compartments for many cellular processes. What are the fitness ...
  • Zacco, Elsa; Graña-Montes, Ricardo; Martin, Stephen R.; Sanchez de Groot, Natalia; Alfano, Caterina; Tartaglia, Gian Gaetano; Pastore, Annalisa (Elsevier, 2019)
    Amyotrophic lateral sclerosis and frontotemporal lobar degeneration are incurable motor neuron diseases associated with muscle weakness, paralysis and respiratory failure. Accumulation of TAR DNA-binding protein 43 (TDP-43) ...
  • González, Rubén; We, Beilei; Li, Xianghua; Martínez, Fernando; Elena, Santiago F. (Oxford University Press, 2019)
    RNA virus high mutation rate is a double-edged sword. At the one side, most mutations jeopardize proteins functions; at the other side, mutations are needed to fuel adaptation. The relevant question then is the ratio between ...
  • Stervbo, Ulrik; Nienen, Mikalai; Weist, Benjamin J. D.; Kuchenbecker, Leon; Hecht, Jochen; Wehler, Patrizia; Westhoff, Timm H.; Reinke, Petra; Babel, Nina (Frontiers Media, 2019)
    Reactivation of the BK polyomavirus is known to lead to severe complications in kidney transplant patients. The current treatment strategy relies on decreasing the immunosuppression to allow the immune system to clear the ...
  • Mixão, Verónica; Perez Hansen, Antonio; Saus Martínez, Ester; Boekhout, Teun; Lass-Florl, Cornelia; Gabaldón Estevan, Juan Antonio, 1973- (Frontiers Media, 2019)
    Fungal infections such as those caused by Candida species are increasingly common complications in immunocompromised patients. The list of causative agents of candidiasis is growing and comprises a set of emerging species ...
  • Janssens, Georges E.; Lin, Xin-Xuan; Millán Ariño, Lluís, 1984-; Kavšek, Alan; Sen, Ilke; Seinstra, Renée I.; Stroustrup, Nicholas; Nollen, Ellen A. A.; Riedel, Christian G. (Elsevier, 2019)
    Aging strongly influences human morbidity and mortality. Thus, aging-preventive compounds could greatly improve our health and lifespan. Here we screened for such compounds, known as geroprotectors, employing the power of ...
  • Picchioni, Daria; Antolin-Fontes, Albert; Camacho, Noelia; Schmitz, Claus; Pons-Pons, Alba; Rodríguez-Escribà, Marta; Machallekidou, Antoni; Güler, Merve Nur; Siatra, Panagiota; Carretero-Junquera, Maria; Serrano, Alba; Hovde, Stacy L.; Knobel, Philip A.; Novoa, Eva Maria; Solà-Vilarrubias, Maria; Kaguni, Laurie S.; Stracker, Travis; Ribas de Pouplana, Lluís (Elsevier, 2019)
    The aminoacylation of tRNAs by aminoacyl-tRNA synthetases (ARSs) is a central reaction in biology. Multiple regulatory pathways use the aminoacylation status of cytosolic tRNAs to monitor and regulate metabolism. The ...
  • Mocavini, Ivano; Pippa, Simone; Licursi, Valerio; Paci, Paola; Trisciuoglio, Daniela; Mannironi, Cecilia; Presutti, Carlo; Negri, Rodolfo (Wiley Open Access, 2019)
    JARID1B/KDM5B histone demethylase's mRNA is markedly overexpressed in breast cancer tissues and cell lines and the protein has been shown to have a prominent role in cancer cell proliferation and DNA repair. However, the ...
  • Castro Giner, Francesc; Künzli, Nino; Jacquemin Leonard, Bénédicte; Forsberg, Bertil; Cid Ibeas, Rafael de; Sunyer Deu, Jordi; Jarvis, Deborah; Briggs, David; Vienneau, Danielle; Norbäck, Dan; Gonzalez, Juan Ramon; Guerra, Stefano; Janson, Christer; Antó i Boqué, Josep Maria; Wjst, Matthias; Heinrich, Joachim; Estivill, Xavier, 1955-; Kogevinas, Manolis (National Institute of Environmental Health Sciences (NIEHS), 2009)
    BACKGROUND: Traffic-related air pollution is related with asthma, and this association may be modified by genetic factors. OBJECTIVES: We investigated the role of genetic polymorphisms potentially modifying the association ...
  • Paetzold, Bernhard, 1981-; Willis, Jesse R.; Pereira de Lima, Joao; Knödlseder, Nastassia; Brüggemann, Holger; Quist, Sven R.; Gabaldón Estevan, Juan Antonio, 1973-; Güell Cargol, Marc (BioMed Central, 2019)
    Background: The skin is colonized by a large number of microorganisms, most of which are beneficial or harmless. However, disease states of skin have specific microbiome compositions that are different from those of healthy ...
  • Le Dily, François; Vidal, Enrique; Cuartero, Yasmina; Quilez Oliete, Javier; Nacht, A. Silvina; Vicent, Guillermo Pablo; Carbonell-Caballero, Jose; Sharma, Priyanka; Villanueva Cañas, José Luis, 1984-; Ferrari, Roberto; De Llobet, Lara Isabel; Verde, Gaetano; Wright, Roni H.G.; Beato, Miguel (Cold Spring Harbor Laboratory Press (CSHL Press), 2019)
    In breast cancer cells, some topologically associating domains (TADs) behave as hormonal gene regulation units, within which gene transcription is coordinately regulated in response to steroid hormones. Here we further ...
  • Perez, Marcos Francisco; Lehner, Ben, 1978- (Nature Research, 2019)
    Animals transmit not only DNA but also other molecules, such as RNA, proteins and metabolites, to their progeny via gametes. It is currently unclear to what extent these molecules convey information between generations and ...
  • Paternoster, Lavinia; Gonzalez, Juan Ramon; Bustamante Pineda, Mariona; Tejedor, Elisabeth; Sunyer Deu, Jordi; Weidinger, Stephan (Nature Research, 2015)
    Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, ...
  • Doñate-Macián, Pau; Gómez, Antonio; Dégano, Irene R.; Perálvarez Marín, Alex (Impact Journal, 2018)
    Proteomics aids to the discovery and expansion of protein-protein interaction networks, which are key to understand molecular mechanisms in physiology and physiopathology, but also to infer protein function in a ...
  • Chen, Lu; Breschi, Alessandra, 1988-; Guigó Serra, Roderic; Palumbo, Emilio; Rendon, Augusto (American Association for the Advancement of Science (AAAS), 2014)
    Blood cells derive from hematopoietic stem cells through stepwise fating events. To characterize gene expression programs driving lineage choice, we sequenced RNA from eight primary human hematopoietic progenitor populations ...
  • Pérez-Lluch, Sílvia; Blanco, Enrique; Tilgner, Hagen, 1980-; Curado, Joao; Ruiz-Romero, Marina; Corominas Guiu, Montserrat; Guigó Serra, Roderic (Nature Research, 2015)
    The interplay of active and repressive histone modifications is assumed to have a key role in the regulation of gene expression. In contrast to this generally accepted view, we show that the transcription of genes temporally ...

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