Center for Genomic Regulation (CRG)

 

The CRG is an International biomedical research institute of excellence created in December 2000. It is a non-profit foundation funded by the Catalan Government through the departments of Economy & Knowledge and Health, the Spanish Ministry of Economy and Competitiveness, and includes the participation of Universitat Pompeu Fabra (UPF).
The mission of the CRG is to discover and advance knowledge for the benefit of society, public health and economic prosperity.
The CRG believes that the medicine of the future depends on the groundbreaking science of today. This requires an interdisciplinary scientific team focused on understanding the complexity of life from the genome and the cell up to an entire organism and its interaction with the environment, offering an integrated view of genetic diseases.

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  • López De Maturana, Evangelina; Rodríguez, Juan Antonio; Lao Grueso, Oscar, 1976-; Iglesias Coma, Mar; Cecchini Rosell, Lluís; Ilzarbe Sánchez, Lucas; Real, Francisco X.; Malats i Riera, Núria (BioMed Central, 2021)
    Background: Pancreatic cancer (PC) is a complex disease in which both non-genetic and genetic factors interplay. To date, 40 GWAS hits have been associated with PC risk in individuals of European descent, explaining 4.1% ...
  • Tian, Tian V.; Di Stefano, Bruno, 1984-; Stik, Grégoire; Vila-Casadesús, Maria; Sardina, Jose Luis; Vidal Ocabo, Enrique; Dasti, Alessandro, 1988-; Segura-Morales, Carolina; de Andrés-Aguayo, Luisa; Gómez, Antonio; Goldmann, Johanna; Jaenisch, Rudolf; Graf, T. (Thomas) (Nature Research, 2019)
    How pluripotent stem cells differentiate into the main germ layers is a key question of developmental biology. Here, we show that the chromatin-related factor Whsc1 (also known as Nsd2 and MMSET) has a dual role in ...
  • Pérez-Lluch, Sílvia; Klein, Cecilia C.; Breschi, Alessandra, 1988-; Ruiz-Romero, Marina; Abad, Amaya; Palumbo, Emilio; Bekish, Lyazzat; Arnan Ros, Carme; Guigó Serra, Roderic (Public Library of Science (PLoS), 2020)
    Natural Antisense Transcripts (NATs) are long non-coding RNAs (lncRNAs) that overlap coding genes in the opposite strand. NATs roles have been related to gene regulation through different mechanisms, including post-transcriptional ...
  • Frankish, Adam; Lagarde, Julien; Carbonell Sala, Silvia; Guigó Serra, Roderic; Flicek, Paul (Oxford University Press, 2021)
    The GENCODE project annotates human and mouse genes and transcripts supported by experimental data with high accuracy, providing a foundational resource that supports genome biology and clinical genomics. GENCODE annotation ...
  • Venturini, Valeria; Pezzano, Fabio; Català Castro, Frederic; Häkkinen, Hanna-Maria; Jiménez-Delgado, Senda; Colomer-Rosell, Mariona; Marro, Monica; Tolosa-Ramon, Queralt; Paz-López, Sonia; Valverde, M. A. (Miguel Ángel), 1963-; Weghuber, Julian; Loza-Alvarez, Pablo; Krieg, Michael; Wieser, Stefan; Ruprecht, Verena (American Association for the Advancement of Science (AAAS), 2020)
    The physical microenvironment regulates cell behavior during tissue development and homeostasis. How single cells decode information about their geometrical shape under mechanical stress and physical space constraints ...
  • Gebauer, Fátima; Schwarzl, Thomas; Valcárcel, J. (Juan); Hentze, Matthias W. (Nature Research, 2020)
    RNA-binding proteins (RBPs) are critical effectors of gene expression, and as such their malfunction underlies the origin of many diseases. RBPs can recognize hundreds of transcripts and form extensive regulatory networks ...
  • Benisty, Hannah, 1986-; Weber, Marc; Hernandez-Alias, Xavier; Schaefer, Martin H.; Serrano Pubull, Luis, 1982- (National Academy of Sciences, 2020)
    It is well known that in cancer gene families some members are more frequently mutated in tumor samples than their family counterparts. A paradigmatic case of this phenomenon is KRAS from the RAS family. Different explanations ...
  • Espejo, Isabel; Di Croce, Luciano; Aranda Aragón, Sergio (Wiley-VCH Verlag, 2020)
    Chromatin-bound proteins underlie several fundamental cellular functions, such as control of gene expression and the faithful transmission of genetic and epigenetic information. Components of the chromatin proteome (the ...
  • Llambrich, Sergi; Wouters, Jens; Himmelreich, Uwe; Dierssen, Mara; Sharpe, James; Gsell, Willy; Martínez Abadías, Neus; Velde, Greetje Vande (Nature Research, 2020)
    Up to 40% of congenital diseases present disturbances of brain and craniofacial development resulting in simultaneous alterations of both systems. Currently, the best available method to preclinically visualize the brain ...
  • Irimia, Manuel; Vellutini, Bruno C.; Marlétaz, Ferdinand; Cetrangolo, Viviana; Cvetesic, Nevena; Thiel, Daniel; Henriet, Simon; Grau Bové, Xavier; Carrillo-Baltodano, Allan M.; Gu, Wenjia; Kerbl, Alexandra; Marquez, Yamile; Bekkouche, Nicolas; Chourrout, Daniel; Gómez Skarmeta, José Luis; Irimia, Manuel; Lenhard, Boris; Worsaae, Katrine; Hejnol, Andreas (Nature Research, 2020)
    The causes and consequences of genome reduction in animals are unclear because our understanding of this process mostly relies on lineages with often exceptionally high rates of evolution. Here, we decode the compact ...
  • Zoonomia Consortium; Serres Armero, Aitor, 1992-; Juan, David; Kuderna, Lukas F.K.; Marquès i Bonet, Tomàs, 1975- (Nature Research, 2020)
    The Zoonomia Project is investigating the genomics of shared and specialized traits in eutherian mammals. Here we provide genome assemblies for 131 species, of which all but 9 are previously uncharacterized, and describe ...
  • Gerdol, Marco; Cruz, Fernando; Gómez-Garrido, Jèssica; Vlasova, Anna; Naranjo Ortiz, Miguel Ángel, 1989-; Corvelo, André; Frias, Leonor; Gut, Marta; Gabaldón Estevan, Juan Antonio, 1973-; Alioto, Tyler; Figueras, Antonio (BioMed Central, 2020)
    Background: The Mediterranean mussel Mytilus galloprovincialis is an ecologically and economically relevant edible marine bivalve, highly invasive and resilient to biotic and abiotic stressors causing recurrent massive ...
  • Ruiz de Porras, Vicenç; Indacochea Cusirramos, Alberto; Aytes, Alvaro (Elsevier, 2020)
    Background: Taxanes are the most active chemotherapy agents in metastatic castration-resistant prostate cancer (mCRPC) patients; yet, resistance occurs almost invariably, representing an important clinical challenge. ...
  • Raote, Ishier; Chabanon, Morgan; Walani, Nikhil; Arroyo, Marino; Garcia-Parajo, Maria F.; Malhotra, Vivek; Campelo, Felix (eLife, 2020)
    The endoplasmic reticulum (ER)-resident protein TANGO1 assembles into a ring around ER exit sites (ERES), and links procollagens in the ER lumen to COPII machinery, tethers, and ER-Golgi intermediate compartment (ERGIC) ...
  • Marti-Renom, Marc A.; Paulsen, Jonas; Jost, Daniel; Marti-Renom, Marc A. (Elsevier, 2020)
    The intrinsic dynamic nature of chromosomes is emerging as a fundamental component in regulating DNA transcription, replication, and damage-repair among other nuclear functions. With this increased awareness, reinforced ...
  • Binenbaum, Ilona; Atamni, Hanifa Abu-Toamih; Fotakis, Georgios; Kontogianni, Georgia; Koutsandreas, Theodoros; Pilalis, Eleftherios; Mott, Richard; Himmelbauer, Heinz; Iraqi, Fuad A.; Chatziioannou, Aristotelis A. (BioMed Central, 2020)
    Background: The Collaborative Cross (CC) mouse population is a valuable resource to study the genetic basis of complex traits, such as obesity. Although the development of obesity is influenced by environmental factors, ...
  • Telford, Marco, 1984-; Hughes, David; Juan, David; Stoneking, Mark; Navarro i Cuartiellas, Arcadi, 1969-; Santpere Baró, Gabriel, 1981- (MDPI, 2020)
    The Epstein-Barr Virus (EBV) infects the vast majority of human individuals worldwide (~90%) and is associated with several diseases, including different types of cancer and multiple sclerosis, which show wide variation ...
  • Santpere Baró, Gabriel, 1981-; Telford, Marco, 1984-; Andrés Benito, Pol; Navarro i Cuartiellas, Arcadi, 1969-; Ferrer, Isidre (MDPI, 2020)
    The human herpesvirus 6 (HHV-6) -A and -B are two dsDNA beta-herpesviruses infectingalmost the entire worldwide population. These viruses have been implicated in multipleneurological conditions in individuals of various ...
  • Pohl, Andy, 1979-; Beato, Miguel (Oxford University Press, 2014)
    BigWig files are a compressed, indexed, binary format for genome-wide signal data for calculations (e.g. GC percent) or experiments (e.g. ChIP-seq/RNA-seq read depth). bwtool is a tool designed to read bigWig files rapidly ...
  • Keyes, William M., 1973-; Pecoraro, Matteo, 1984-; Aranda, Victoria; Vernersson Lindahl, Emma; Li, Wangzhi; Vogel, Hannes; Guo, Xuecui; Garcia, Elvin L.; Michurina, Tatyana V.; Enikolopov, Grigori; Muthuswamy, Senthil K.; Mills, Alea A. (Elsevier, 2011)
    The p53 homolog p63 is essential for development, yet its role in cancer is not clear. We discovered that p63 deficiency evokes the tumor-suppressive mechanism of cellular senescence, causing a striking absence of stratified ...

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