ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay

Poliński, Patryk; Miret-Cuesta, Marta; Irimia Martínez, Manuel

doi:http://dx.doi.org/10.1002/cm.22051

ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay

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Poliński P, Cuesta MM, Irimia M. ARC expands the DAAM1 microexon-mediated actin-RHOA/ROCK Interplay. Cytoskeleton (Hoboken). 2025 Jun 9. DOI: 10.1002/cm.22051

Abstract

Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural-specific microexon in DAAM1 in modulating actin's role in synaptic processes. This article discusses the impact of this microexon on actin polymerization, the RHOA/ROCK signaling pathway, and cognitive functions. Furthermore, we present new results that reveal a more complex scenario involving the upregulation of the activity-regulated cytoskeleton-associated protein (ARC) protein in DAAM1 microexon KO models, which may further affect synaptic function and cognition.