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Estimation of the viscoelastic properties of vessel walls using a computational model and Doppler ultrasound

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dc.contributor.author Balocco, Simone
dc.contributor.author Basset, Olivier
dc.contributor.author Courbebaisse, Guy
dc.contributor.author Boni, Enrico
dc.contributor.author Frangi Caregnato, Alejandro
dc.contributor.author Tortoli, Piero
dc.contributor.author Cachard, Christian
dc.contributor.other Universitat Pompeu Fabra
dc.date.accessioned 2012-07-09T09:58:40Z
dc.date.available 2012-07-09T09:58:40Z
dc.date.issued 2010
dc.identifier.citation Balocco S, Basset O, Courbebaisse G, Boni E, Frangi AF, Tortoli P, Cachard C. Estimation of the viscoelastic properties of vessel walls using a computational model and Doppler ultrasound. Phys Med Biol. 2010; 55(12): 3557-3575. DOI: 10.1088/0031-9155/55/12/019
dc.identifier.issn 0031-9155
dc.identifier.uri http://hdl.handle.net/10230/16684
dc.description.abstract Human arteries affected by atherosclerosis are characterized by altered wall viscoelastic properties. The possibility of noninvasively assessing arterial viscoelasticity in vivo would significantly contribute to the early diagnosis and prevention of this disease. This paper presents a noniterative technique to estimate the viscoelastic parameters of a vascular wall Zener model. The approach requires the simultaneous measurement of flow variations and wall displacements, which can be provided by suitable ultrasound Doppler instruments. Viscoelastic parameters are estimated by fitting the theoretical constitutive equations to the experimental measurements using an ARMA parameter approach. The accuracy and sensitivity of the proposed method are tested using reference data generated by numerical simulations of arterial pulsation in which the physiological conditions and the viscoelastic parameters of the model can be suitably varied. The estimated values quantitatively agree with the reference values, showing that the only parameter affected by changing the physiological conditions is viscosity, whose relative error was about 27% even when a poor signal-to-noise ratio is simulated. Finally, the feasibility of the method is illustrated through three measurements made at different flow regimes on a cylindrical vessel phantom, yielding a parameter mean estimation error of 25%.
dc.description.sponsorship This work has been partially funded by the Industrial and Technological Development Centre (CDTI) within the CENIT Programme (CDTEAM Project), the EC @neurIST (IST-FP6-2004-027703) projects, by BQR INSA-Lyon and by the Italian/nMinistry of University & Research (COFIN-PRIN 2005).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Institute of Physics (IOP)
dc.relation.ispartof Phys Med Biol. 2010; 55(12): 3557-3575
dc.rights © 2010, Institute of Physics (IOP). Published article available at http://iopscience.iop.org/0031-9155/55/12/019/
dc.subject.other Sistema cardiovascular -- Malalties
dc.subject.other Artèries -- Malalties
dc.subject.other Aterosclerosi
dc.title Estimation of the viscoelastic properties of vessel walls using a computational model and Doppler ultrasound
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1088/0031-9155/55/12/019
dc.subject.keyword Terms—Viscoelasticity
dc.subject.keyword Arterial wall model
dc.subject.keyword Noninvasive measurement
dc.subject.keyword ARMA parameter fitting
dc.relation.projectID info:eu-repo/grantAgreement/EC/FP6/027703
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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