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A genomic analysis identifies a novel component in the genetic structure of sub-Saharan African populations

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dc.contributor.author Sikora, Martin, 1976-
dc.contributor.author Laayouni, Hafid, 1968-
dc.contributor.author Calafell i Majó, Francesc
dc.contributor.author Comas, David, 1969-
dc.contributor.author Bertranpetit, Jaume, 1952-
dc.date.accessioned 2012-02-15T08:34:52Z
dc.date.available 2012-02-15T08:34:52Z
dc.date.issued 2011
dc.identifier.citation Sikora M, Laayouni H, Calafell F, Comas D, Bertranpetit J. A genomic analysis identifies a novel component in the genetic structure of sub-Saharan African populations. European Journal of Human Genetics. 2011;19:84-8. DOI: 10.1038/ejhg.2010.141
dc.identifier.issn 1018-4813
dc.identifier.uri http://hdl.handle.net/10230/16235
dc.description.abstract Studies of large sets of SNP data have proven to be a powerful tool in the analysis of the genetic structure of human populations. In this work, we analyze genotyping data for 2,841 SNPs in 12 Sub-Saharan African populations, including a previously unsampled region of south-eastern Africa (Mozambique). We show that robust results in a world-wide perspective can be obtained when analyzing only 1,000 SNPs. Our main results both confirm the results of previous studies, and show new and interesting features in Sub-Saharan African genetic complexity. There is a strong differentiation of Nilo-Saharans, much beyond what would be expected by geography. Hunter-gatherer populations (Khoisan and Pygmies) show a clear distinctiveness with very intrinsic Pygmy (and not only Khoisan) genetic features. Populations of the West Africa present an unexpected similarity among them, possibly the result of a population expansion. Finally, we find a strong differentiation of the south-eastern Bantu population from Mozambique, which suggests an assimilation of a pre-Bantu substrate by Bantu speakers in the region.
dc.description.sponsorship This research was supported by Dirección General de Investigación, Ministerio de Ciencia y Tecnología, Spain (grants SAF2007-63171, BFU2007-63657) and Direcció General de Recerca, Generalitat de Catalunya (2009 SGR 1101). SNP genotyping services were provided by the Spanish "Centro Nacional de Genotipado" (CEGEN; http://www.cegen.org); Bioinformatic services were kindly provided by the Genomic Diversity node, Spanish Bioinformatic Institute (www.inab.org). MS was supported by a PhD fellowship from the Programa de becas FPU del Ministerio de Educación y Ciencia, Spain (AP2005-3982).
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher Nature Publishing Group
dc.relation.ispartof European Journal of Human Genetics. 2011;19:84-8
dc.rights © 2011 Macmillan Publishers Limited All rights reserved
dc.subject.other Genètica de poblacions -- Àfrica subsahariana
dc.subject.other Genètica de poblacions humanes
dc.subject.other Evolució molecular
dc.subject.other Genètica evolutiva
dc.title A genomic analysis identifies a novel component in the genetic structure of sub-Saharan African populations
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1038/ejhg.2010.141
dc.subject.keyword Population genetics
dc.subject.keyword Africa
dc.subject.keyword Population history
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/SAF2007-63171
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/BFU2007-63657
dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/AP2005-3982
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/acceptedVersion

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