A genomic analysis identifies a novel component in the genetic structure of sub-Saharan African populations
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- dc.contributor.author Sikora, Martin, 1976-ca
- dc.contributor.author Laayouni, Hafid, 1968-ca
- dc.contributor.author Calafell i Majó, Francescca
- dc.contributor.author Comas, David, 1969-ca
- dc.contributor.author Bertranpetit, Jaume, 1952-ca
- dc.date.accessioned 2012-02-15T08:34:52Z
- dc.date.available 2012-02-15T08:34:52Z
- dc.date.issued 2011ca
- dc.description.abstract Studies of large sets of SNP data have proven to be a powerful tool in the analysis of the genetic structure of human populations. In this work, we analyze genotyping data for 2,841 SNPs in 12 Sub-Saharan African populations, including a previously unsampled region of south-eastern Africa (Mozambique). We show that robust results in a world-wide perspective can be obtained when analyzing only 1,000 SNPs. Our main results both confirm the results of previous studies, and show new and interesting features in Sub-Saharan African genetic complexity. There is a strong differentiation of Nilo-Saharans, much beyond what would be expected by geography. Hunter-gatherer populations (Khoisan and Pygmies) show a clear distinctiveness with very intrinsic Pygmy (and not only Khoisan) genetic features. Populations of the West Africa present an unexpected similarity among them, possibly the result of a population expansion. Finally, we find a strong differentiation of the south-eastern Bantu population from Mozambique, which suggests an assimilation of a pre-Bantu substrate by Bantu speakers in the region.en
- dc.description.sponsorship This research was supported by Dirección General de Investigación, Ministerio de Ciencia y Tecnología, Spain (grants SAF2007-63171, BFU2007-63657) and Direcció General de Recerca, Generalitat de Catalunya (2009 SGR 1101). SNP genotyping services were provided by the Spanish "Centro Nacional de Genotipado" (CEGEN; http://www.cegen.org); Bioinformatic services were kindly provided by the Genomic Diversity node, Spanish Bioinformatic Institute (www.inab.org). MS was supported by a PhD fellowship from the Programa de becas FPU del Ministerio de Educación y Ciencia, Spain (AP2005-3982).en
- dc.format.mimetype application/pdfca
- dc.identifier.citation Sikora M, Laayouni H, Calafell F, Comas D, Bertranpetit J. A genomic analysis identifies a novel component in the genetic structure of sub-Saharan African populations. European Journal of Human Genetics. 2011;19:84-8. DOI: 10.1038/ejhg.2010.141ca
- dc.identifier.doi http://dx.doi.org/10.1038/ejhg.2010.141
- dc.identifier.issn 1018-4813ca
- dc.identifier.uri http://hdl.handle.net/10230/16235
- dc.language.iso engca
- dc.publisher Nature Publishing Groupca
- dc.relation.ispartof European Journal of Human Genetics. 2011;19:84-8
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/SAF2007-63171
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/BFU2007-63657
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PN/AP2005-3982
- dc.rights © 2011 Macmillan Publishers Limited All rights reservedca
- dc.rights.accessRights info:eu-repo/semantics/openAccessen
- dc.subject.keyword Population geneticsen
- dc.subject.keyword Africaen
- dc.subject.keyword Population historyen
- dc.subject.other Genètica de poblacions -- Àfrica subsaharianaca
- dc.subject.other Genètica de poblacions humanesca
- dc.subject.other Evolució molecularca
- dc.subject.other Genètica evolutivaca
- dc.title A genomic analysis identifies a novel component in the genetic structure of sub-Saharan African populationsca
- dc.type info:eu-repo/semantics/articleca
- dc.type.version info:eu-repo/semantics/acceptedVersionen