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Association between GIS-based exposure to urban air pollution during pregnancy and birth weight in the INMA Sabadell Cohort

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dc.contributor.author Aguilera Jiménez, Inmaculada, 1977-
dc.contributor.author Guxens Junyent, Mònica
dc.contributor.author García Esteban, Raquel
dc.contributor.author Sunyer Deu, Jordi
dc.contributor.author Corbella, Teresa
dc.contributor.author Nieuwenhuijsen, Mark J.
dc.contributor.author Foradada, Carles M.
dc.date.accessioned 2011-06-01T11:01:32Z
dc.date.available 2011-06-01T11:01:32Z
dc.date.issued 2009
dc.identifier.citation Aguilera I, Guxens M, Garcia-Esteban R, Corbella T, Nieuwenhuijsen MJ, Foradada CM et al. Association between GIS-Based Exposure to Urban Air Pollution during Pregnancy and Birth Weight in the INMA Sabadell Cohort. Environ Health Perspect. 2009;117(8):1922-7. DOI: 10.1289/ehp.0800256
dc.identifier.issn 0091-6765
dc.identifier.uri http://hdl.handle.net/10230/11705
dc.description.abstract Background: There is growing evidence that traffic-related air pollution reduces birth weight. Improving exposure assessment is a key issue to advance in this research area./nObjective: We investigated the effect of prenatal exposure to traffic-related air pollution via geographic information system (GIS) models on birth weight in 570 newborns from the INMA (Environment and Childhood) Sabadell cohort./nMethods: We estimated pregnancy and trimester-specific exposures to nitrogen dioxide and aromatic hydrocarbons [benzene, toluene, ethylbenzene, m/p-xylene, and o-xylene (BTEX)] by using temporally adjusted land-use regression (LUR) models. We built models for NO2 and BTEX using four and three 1-week measurement campaigns, respectively, at 57 locations. We assessed the relationship between prenatal air pollution exposure and birth weight with linear regression models. We performed sensitivity analyses considering time spent at home and time spent in nonresidential outdoor environments during pregnancy./nResults: In the overall cohort, neither NO2 nor BTEX exposure was significantly associated with birth weight in any of the exposure periods. When considering only women who spent < 2 hr/day in nonresidential outdoor environments, the estimated reductions in birth weight associated with an interquartile range increase in BTEX exposure levels were 77 g [95% confidence interval (CI), 7–146 g] and 102 g (95% CI, 28–176 g) for exposures during the whole pregnancy and the second trimester, respectively. The effects of NO2 exposure were less clear in this subset./nConclusions: The association of BTEX with reduced birth weight underscores the negative role of vehicle exhaust pollutants in reproductive health. Time–activity patterns during pregnancy complement GIS-based models in exposure assessment.
dc.format.mimetype application/pdf
dc.language.iso eng
dc.publisher National Institute of Environmental Health Sciences
dc.relation.ispartof Environmental Health Perspectives. 2009;117(8):1322-7
dc.rights © National Institute of Environmental Health Sciences
dc.subject.other Sabadell (Catalunya) -- Condicions ambientals
dc.subject.other Aire -- Contaminació -- Catalunya -- Sabadell
dc.subject.other Embaràs -- Catalunya -- Sabadell
dc.subject.other Pes al néixer -- Catalunya -- Sabadell
dc.title Association between GIS-based exposure to urban air pollution during pregnancy and birth weight in the INMA Sabadell Cohort
dc.type info:eu-repo/semantics/article
dc.identifier.doi http://dx.doi.org/10.1289/ehp.0800256
dc.subject.keyword Air pollution
dc.subject.keyword Aromatic hydrocarbons
dc.subject.keyword Birth weight
dc.subject.keyword Cohort study
dc.subject.keyword Exposure assessment
dc.subject.keyword Geographic information system
dc.subject.keyword INMA study
dc.subject.keyword Pregnancy
dc.subject.keyword Nitrogen dioxide
dc.rights.accessRights info:eu-repo/semantics/openAccess
dc.type.version info:eu-repo/semantics/publishedVersion

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