Association between GIS-based exposure to urban air pollution during pregnancy and birth weight in the INMA Sabadell Cohort

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• dc.contributor.author Aguilera Jiménez, Inmaculada, 1977-ca
• dc.contributor.author Guxens Junyent, Mònicaca
• dc.contributor.author García Esteban, Raquelca
• dc.contributor.author Sunyer Deu, Jordica
• dc.contributor.author Corbella, Teresaca
• dc.contributor.author Nieuwenhuijsen, Mark J.ca
• dc.contributor.author Foradada, Carles M.ca
• dc.date.accessioned 2011-06-01T11:01:32Z
• dc.date.available 2011-06-01T11:01:32Z
• dc.date.issued 2009ca
• dc.description.abstract Background: There is growing evidence that traffic-related air pollution reduces birth weight. Improving exposure assessment is a key issue to advance in this research area./nObjective: We investigated the effect of prenatal exposure to traffic-related air pollution via geographic information system (GIS) models on birth weight in 570 newborns from the INMA (Environment and Childhood) Sabadell cohort./nMethods: We estimated pregnancy and trimester-specific exposures to nitrogen dioxide and aromatic hydrocarbons [benzene, toluene, ethylbenzene, m/p-xylene, and o-xylene (BTEX)] by using temporally adjusted land-use regression (LUR) models. We built models for NO2 and BTEX using four and three 1-week measurement campaigns, respectively, at 57 locations. We assessed the relationship between prenatal air pollution exposure and birth weight with linear regression models. We performed sensitivity analyses considering time spent at home and time spent in nonresidential outdoor environments during pregnancy./nResults: In the overall cohort, neither NO2 nor BTEX exposure was significantly associated with birth weight in any of the exposure periods. When considering only women who spent < 2 hr/day in nonresidential outdoor environments, the estimated reductions in birth weight associated with an interquartile range increase in BTEX exposure levels were 77 g [95% confidence interval (CI), 7–146 g] and 102 g (95% CI, 28–176 g) for exposures during the whole pregnancy and the second trimester, respectively. The effects of NO2 exposure were less clear in this subset./nConclusions: The association of BTEX with reduced birth weight underscores the negative role of vehicle exhaust pollutants in reproductive health. Time–activity patterns during pregnancy complement GIS-based models in exposure assessment.
• dc.format.mimetype application/pdfca
• dc.identifier.citation Aguilera I, Guxens M, Garcia-Esteban R, Corbella T, Nieuwenhuijsen MJ, Foradada CM et al. Association between GIS-Based Exposure to Urban Air Pollution during Pregnancy and Birth Weight in the INMA Sabadell Cohort. Environ Health Perspect. 2009;117(8):1922-7. DOI: 10.1289/ehp.0800256
• dc.identifier.doi http://dx.doi.org/10.1289/ehp.0800256
• dc.identifier.issn 0091-6765
• dc.identifier.uri http://hdl.handle.net/10230/11705
• dc.language.iso engca
• dc.publisher National Institute of Environmental Health Sciencesca
• dc.relation.ispartof Environmental Health Perspectives. 2009;117(8):1322-7
• dc.rights © National Institute of Environmental Health Sciencesca
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.subject.keyword Air pollution
• dc.subject.keyword Aromatic hydrocarbons
• dc.subject.keyword Birth weight
• dc.subject.keyword Cohort study
• dc.subject.keyword Exposure assessment
• dc.subject.keyword Geographic information system
• dc.subject.keyword INMA study
• dc.subject.keyword Pregnancy
• dc.subject.keyword Nitrogen dioxide
• dc.subject.other Sabadell (Catalunya) -- Condicions ambientals
• dc.subject.other Aire -- Contaminació -- Catalunya -- Sabadell
• dc.subject.other Embaràs -- Catalunya -- Sabadell
• dc.subject.other Pes al néixer -- Catalunya -- Sabadell
• dc.title Association between GIS-based exposure to urban air pollution during pregnancy and birth weight in the INMA Sabadell Cohortca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersion