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The institutional repository collects, disseminates and preserves, in digital form, the intellectual output that results from the academic and research activity of the UPF and also the scientific magazines and the institutional publications. Its purpose is to increase the impact of research done at the UPF and its intellectual memory.

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A VNS approach for book marketing campaigns generated with quasi-bicliques probabilities

Oliveira, Thays A.; Coelho, Vitor N.; Ramalhinho, Helena; Souza, Marcone J.F.; Coelho, Bruno N.; Rezende, Daniel C.; Coelho, Igor M. (Elsevier, 2017)

This paper focuses on Book Marketing Campaigns, where the benefit of offering each book is calculated based on a bipartite graph (biclique). A quasi Biclique problem is assessed for obtaining the probabilities of success ...
The Suv420h histone methyltransferases regulate PPAR-γ and energy expenditure in response to environmental stimuli

Pedrotti, Simona; Caccia, Roberta; Neguembor, Maria Victoria; García Manteiga, José Manuel; Ferri, Giulia; Palma, Clara de; Canu, Tamara; Giovarelli, Matteo; Marra, Paolo; Fiocchi, Amleto; Molineris, Ivan; Raso, Michele; Sanvito, Francesca; Doglioni, Claudio; Esposito, Antonio; Clementi, Emilio; Gabellini, Davide (American Association for the Advancement of Science (AAAS), 2019)

Obesity and its associated metabolic abnormalities have become a global emergency with considerable morbidity and mortality. Epidemiologic and animal model data suggest an epigenetic contribution to obesity. Nevertheless, ...
Controlled ploidy reduction of pluripotent 4n cells generates 2n cells during mouse embryo development

Frade, João; Nakagawa, Shoma; Cortes, Paola; Di Vicino, Umberto; Romo Saladrigas, Neus, 1982-; Lluis Viñas, Frederic; Cosma, Maria Pia, 1970- (American Association for the Advancement of Science (AAAS), 2019)

Cells with high ploidy content are common in mammalian extraembryonic and adult tissues. Cell-to-cell fusion generates polyploid cells during mammalian development and tissue regeneration. However, whether increased ploidy ...
Protein-assisted RNA fragment docking (RnaX) for modeling RNA-protein interactions using ModelX

Delgado Blanco, Javier; Radusky, Leandro; Cianferoni, Damiano; Serrano Pubull, Luis, 1982- (National Academy of Sciences, 2019)

RNA-protein interactions are crucial for such key biological processes as regulation of transcription, splicing, translation, and gene silencing, among many others. Knowing where an RNA molecule interacts with a target ...
CRISPR editing of sftb-1/SF3B1 in Caenorhabditis elegans allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicing

Serrat Farran, Xènia, 1993-; Kukhtar, Dmytro; Cornes Maragliano, Eric, 1987-; Esteve-Codina, Anna; Benlloch, Helena; Cecere, Germano; Cerón Madrigal, Julián (Public Library of Science (PLoS), 2019)

SF3B1 is the most frequently mutated splicing factor in cancer. Mutations in SF3B1 likely confer clonal advantages to cancer cells but they may also confer vulnerabilities that can be therapeutically targeted. SF3B1 cancer ...