• Integrated analysis of germline and tumor DNA identifies new candidate genes involved in familial colorectal cancer

  Díaz-Gay, Marcos; Park, Solip; Parra Farré, Genís; Laurie, Steven, 1973-; Beltran, Sergi; Castellví Bel, Sergi (MDPI, 2019)

  Colorectal cancer (CRC) shows aggregation in some families but no alterations in the known hereditary CRC genes. We aimed to identify new candidate genes which are potentially involved in germline predisposition to familial ...
• Systems genetics of hepatic metabolome reveals octopamine as a target for non-alcoholic fatty liver disease treatment

  Brial, Francois; Le Lay, Aurélie; Hedjazi, Lyamine; Tsang, Tsz; Fearnside, Jane F.; Otto, Georg W.; Alzaid, Fawaz; Wilder, Steven P.; Venteclef, Nicolas; Cazier, Jean-Baptiste; Nicholson, Jeremy K.; Day, Chris; Burt, Alastair D.; Gut, Ivo Glynne; Lathrop, Mark; Dumas, Marc-Emmanuel; Gauguier, Dominique (Nature Research, 2019)

  Non-alcoholic fatty liver disease (NAFLD) is often associated with obesity and type 2 diabetes. To disentangle etiological relationships between these conditions and identify genetically-determined metabolites involved in ...
• The cochaperone CHIP marks Hsp70- and Hsp90-bound substrates for degradation through a very flexible mechanism

  Quintana-Gallardo, Lucía; Martín-Benito, Jaime; Marcilla, Miguel; Espadas, Guadalupe; Sabidó Aguadé, Eduard, 1981-; Valpuesta, José M. (Nature Research, 2019)

  Some molecular chaperones are involved not only in assisting the folding of proteins but also, given appropriate conditions, in their degradation. This is the case for Hsp70 and Hsp90 which, in concert with the cochaperone ...
• Tuberculosis exacerbates HIV-1 infection through IL-10/STAT3-dependent tunneling nanotube formation in macrophages

  Souriant, Shanti; Lastrucci, Claire; Vérollet, Christel (Elsevier, 2019)

  The tuberculosis (TB) bacillus, Mycobacterium tuberculosis (Mtb), and HIV-1 act synergistically; however, the mechanisms by which Mtb exacerbates HIV-1 pathogenesis are not well known. Using in vitro and ex vivo cell culture ...
• Single cell RNA-seq identifies the origins of heterogeneity in efficient cell transdifferentiation and reprogramming

  Francesconi, Mirko; Di Stefano, Bruno, 1984-; Berenguer, Clara; de Andrés-Aguayo, Luisa; Plana-Carmona, Marcos; Mendez-Lago, Maria; Guillaumet-Adkins, Amy; Rodríguez Esteban, Gustavo; Gut, Marta; Gut, Ivo Glynne; Heyn, Holger; Lehner, Ben, 1978-; Graf, T. (Thomas) (eLife, 2019)

  Forced transcription factor expression can transdifferentiate somatic cells into other specialised cell types or reprogram them into induced pluripotent stem cells (iPSCs) with variable efficiency. To better understand the ...

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