The making of the oral microbiome in Agta hunter–gatherers
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- dc.contributor.author Dobón Berenguer, Begoña, 1987-
- dc.contributor.author Musciotto, Federico
- dc.contributor.author Mira, Alex
- dc.contributor.author Greenacre, Michael
- dc.contributor.author Schlaepfer, Rodolph
- dc.contributor.author Aguileta, Gabriela
- dc.contributor.author Astete, Leonora H.
- dc.contributor.author Ngales, Marilyn
- dc.contributor.author Latora, Vito
- dc.contributor.author Battiston, Federico
- dc.contributor.author Vinicius, Lucio
- dc.contributor.author Migliano, Andrea Bamberg
- dc.contributor.author Bertranpetit, Jaume, 1952-
- dc.date.accessioned 2023-07-04T06:28:11Z
- dc.date.available 2023-07-04T06:28:11Z
- dc.date.issued 2023
- dc.description.abstract Ecological and genetic factors have influenced the composition of the human microbiome during our evolutionary history. We analysed the oral microbiota of the Agta, a hunter–gatherer population where some members have adopted an agricultural diet. We show that age is the strongest factor modulating the microbiome, probably through immunosenescence since we identified an increase in the number of species classified as pathogens with age. We also characterised biological and cultural processes generating sexual dimorphism in the oral microbiome. A small subset of oral bacteria is influenced by the host genome, linking host collagen genes to bacterial biofilm formation. Our data also suggest that shifting from a fish/meat diet to a rice-rich diet transforms their microbiome, mirroring the Neolithic transition. All of these factors have implications in the epidemiology of oral diseases. Thus, the human oral microbiome is multifactorial and shaped by various ecological and social factors that modify the oral environment.
- dc.description.sponsorship A.B.M was funded by Leverhulme Trust Grant RP2011-R 045 and PLP-2017-323. J.B. received grant PID2019-110933GB-I00/AEI/10.13039/501100011033 from the Agencia Estatal Investigación (AEI), Spain, grant GRC 2017 SGR 702 from Secretaria d'Universitats i Recerca del Departament d'Economia i Coneixement de la Generalitat de Catalunya, as well as grant CEX2018-000792-M, part of the ‘Unidad de Excelencia María de Maeztu’ funded by the MCIN and the AEI, which granted the microbiome analysis by the Servei de Genòmica at Universitat Pompeu Fabra. A.M. is funded by grant RTI2018-102032-B-100 from AEI (Spain).
- dc.format.mimetype application/pdf
- dc.identifier.citation Dobon B, Musciotto F, Mira A, Greenacre M, Schlaepfer R, Aguileta G, Astete LH, Ngales M, Latora V, Battiston F, Vinicius L, Migliano AB, Bertranpetit J. The making of the oral microbiome in Agta hunter–gatherers. Evol Hum Sci. 2023;5:e13. DOI: 10.1017/ehs.2023.9
- dc.identifier.doi http://dx.doi.org/10.1017/ehs.2023.9
- dc.identifier.issn 2513-843X
- dc.identifier.uri http://hdl.handle.net/10230/57441
- dc.language.iso eng
- dc.publisher Cambridge University Press
- dc.relation.ispartof Evolutionary Human Sciences. 2023;5:e13.
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-110933GB-I00
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000792-M
- dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/RTI2018-102032-B-100
- dc.rights © The Author(s), 2023. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
- dc.rights.accessRights info:eu-repo/semantics/openAccess
- dc.rights.uri http://creativecommons.org/licenses/by/4.0/
- dc.subject.keyword hunter–gatherers
- dc.subject.keyword oral microbiome
- dc.subject.keyword Neolithic transition
- dc.subject.keyword pathogen transmission
- dc.title The making of the oral microbiome in Agta hunter–gatherers
- dc.type info:eu-repo/semantics/article
- dc.type.version info:eu-repo/semantics/publishedVersion