Dual role of Snail1 as transcriptional repressor and activator

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• dc.contributor.author García de Herreros, Antonio
• dc.date.accessioned 2024-10-17T06:04:32Z
• dc.date.embargoEnd info:eu-repo/date/embargoEnd/2024-12-02
• dc.date.issued 2024
• dc.description.abstract Snail1 transcriptional factor plays a key role in the control of epithelial to mesenchymal transition, a process that remodels tumor cells increasing their invasion and chemo-resistance as well as reprograms their metabolism and provides stemness properties. During this transition, Snail1 acts as a transcriptional repressor and, as growing evidences have demonstrated, also as a direct activator of mesenchymal genes. In this review, I describe the different proteins that interact with Snail1 and are responsible for these two different functions on gene expression; I focus on the transcriptional factors that associate to Snail1 in their target promoters, both activated and repressed. I also present working models for Snail1 action both as repressor and activator and raise some issues that still need to be investigated.
• dc.description.sponsorship Work in my laboratory is supported by grants PID2019‐104698RB‐I00 and PID2022‐136968OB‐I00 funded by MCIN/AEI/10.13039/501100011033. I apologize if some Snail1 repression target, defined as indicated in Table 1, might have been unnoticed.
• dc.embargo.liftdate 2024-12-02
• dc.format.mimetype application/pdf
• dc.identifier.citation García de Herreros A. Dual role of Snail1 as transcriptional repressor and activator. Biochim Biophys Acta Rev Cancer. 2024 Jan;1879(1):189037. DOI: 10.1016/j.bbcan.2023.189037
• dc.identifier.doi http://dx.doi.org/10.1016/j.bbcan.2023.189037
• dc.identifier.issn 1879-2561
• dc.identifier.uri http://hdl.handle.net/10230/61507
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Biochim Biophys Acta Rev Cancer. 2024 Jan;1879(1):189037
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-104698RB-I00
• dc.relation.projectID info:eu-repo/grantAgreement/ES/3PE/PID2022-136968OB-I00
• dc.rights © Elsevier http://dx.doi.org/10.1016/j.bbcan.2023.189037
• dc.rights.accessRights info:eu-repo/semantics/embargoedAccess
• dc.subject.keyword EMT
• dc.subject.keyword Gene activation
• dc.subject.keyword Gene repression
• dc.subject.keyword Snail1
• dc.title Dual role of Snail1 as transcriptional repressor and activator
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/acceptedVersion