Mapping alterations in the local synchrony of the cerebral cortex in schizophrenia

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• dc.contributor.author Pujol, Jesús
• dc.contributor.author Pujol, Nuria
• dc.contributor.author Mané Santacana, Anna
• dc.contributor.author Martínez-Vilavella, Gerard
• dc.contributor.author Deus, Joan
• dc.contributor.author Pérez Solá, Victor
• dc.contributor.author Blanco Hinojo, Laura, 1981-
• dc.date.accessioned 2024-03-18T07:43:24Z
• dc.date.available 2024-03-18T07:43:24Z
• dc.date.issued 2023
• dc.description.abstract Background: Observations from different fields of research coincide in indicating that a defective gamma-aminobutyric acid (GABA) interneuron system may be among the primary factors accounting for the varied clinical expression of schizophrenia. GABA interneuron deficiency is locally expressed in the form of neural activity desynchronization. We mapped the functional anatomy of local synchrony in the cerebral cortex in schizophrenia using functional connectivity MRI. Methods: Data from 86 patients with schizophrenia and 137 control subjects were obtained from publicly available repositories. Resting-state functional connectivity maps based on Iso-Distant Average Correlation measures across three distances were estimated detailing the local functional structure of the cerebral cortex. Results: Patients with schizophrenia showed weaker local functional connectivity (i.e., lower MRI signal synchrony) in (i) prefrontal lobe areas, (ii) somatosensory, auditory, visual, and motor cortices, (iii) paralimbic system at the anterior insula and anterior cingulate cortex, and (iv) hippocampus. The distribution of the defect in cortical area synchrony largely coincided with the synchronization effect of the GABA agonist alprazolam previously observed using identical functional connectivity measures. There was also a notable resemblance between the anatomy of our findings and cortical areas showing higher density of parvalbumin (prefrontal lobe and sensory cortices) and somatostatin (anterior insula and anterior cingulate cortex) GABA interneurons in humans. Conclusions: Our results thus provide detail of the functional anatomy of synchrony changes in the cerebral cortex in schizophrenia and suggest which elements of the interneuron system are affected. Such information could ultimately be relevant in the search for specific treatments.
• dc.format.mimetype application/pdf
• dc.identifier.citation Pujol J, Pujol N, Mané A, Martínez-Vilavella G, Deus J, Pérez-Sola V, Blanco-Hinojo L. Mapping alterations in the local synchrony of the cerebral cortex in schizophrenia. Eur Psychiatry. 2023 Oct 18;66(1):e84. DOI: 10.1192/j.eurpsy.2023.2463
• dc.identifier.doi http://dx.doi.org/10.1192/j.eurpsy.2023.2463
• dc.identifier.issn 0924-9338
• dc.identifier.uri http://hdl.handle.net/10230/59449
• dc.language.iso eng
• dc.publisher Cambridge University Press
• dc.relation.ispartof Eur Psychiatry. 2023 Oct 18;66(1):e84
• dc.rights © The Author(s), 2023. Published by Cambridge University Press on behalf of the European Psychiatric Association. This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0
• dc.subject.keyword Functional connectivity
• dc.subject.keyword Gamma-aminobutyric acid
• dc.subject.keyword Parvalbumin
• dc.subject.keyword Psychosis
• dc.subject.keyword Somatostatin
• dc.title Mapping alterations in the local synchrony of the cerebral cortex in schizophrenia
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion