Epigenetic clocks in relapse after a first episode of schizophrenia

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• dc.contributor.author González Segura, Àlex
• dc.contributor.author Berge Baquero, Daniel
• dc.contributor.author 2EPs Group
• dc.date.accessioned 2023-02-14T07:05:16Z
• dc.date.available 2023-02-14T07:05:16Z
• dc.date.issued 2022
• dc.description.abstract The main objective of the present study was to investigate the association between several epigenetic clocks, covering different aspects of aging, with schizophrenia relapse evaluated over a 3-year follow-up period in a cohort of ninety-one first-episode schizophrenia patients. Genome-wide DNA methylation was profiled and four epigenetic clocks, including epigenetic clocks of chronological age, mortality and telomere length were calculated. Patients that relapsed during the follow-up showed epigenetic acceleration of the telomere length clock (p = 0.030). Shorter telomere length was associated with cognitive performance (working memory, r = 0.31 p = 0.015; verbal fluency, r = 0.28 p = 0.028), but no direct effect of cognitive function or symptom severity on relapse was detected. The results of the present study suggest that epigenetic age acceleration could be involved in the clinical course of schizophrenia and could be a useful marker of relapse when measured in remission stages.
• dc.format.mimetype application/pdf
• dc.identifier.citation Segura ÀG, Prohens L, Mezquida G, Amoretti S, Bioque M, Ribeiro M, et al. Epigenetic clocks in relapse after a first episode of schizophrenia. Schizophrenia (Heidelb). 2022 Jul 22;8(1):61. DOI: 10.1038/s41537-022-00268-2
• dc.identifier.doi http://dx.doi.org/10.1038/s41537-022-00268-2
• dc.identifier.issn 2754-6993
• dc.identifier.uri http://hdl.handle.net/10230/55754
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Schizophrenia (Heidelb). 2022 Jul 22;8(1):61
• dc.rights © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Biomarkers
• dc.subject.keyword Epigenetics in the nervous system
• dc.subject.keyword Schizophrenia
• dc.title Epigenetic clocks in relapse after a first episode of schizophrenia
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion