Red blood cell omega-3 fatty acids and attention scores in healthy adolescents

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• dc.contributor.author Pinar-Martí, Ariadna
• dc.contributor.author Fernández-Barrés, Sílvia
• dc.contributor.author Gignac, Florence
• dc.contributor.author Persavento, Cecilia
• dc.contributor.author Delgado, Anna
• dc.contributor.author Romaguera Bosch, Dora
• dc.contributor.author Lázaro, Iolanda
• dc.contributor.author Ros, Emilio
• dc.contributor.author López Vicente, Mònica, 1988-
• dc.contributor.author Salas Salvadó, Jordi
• dc.contributor.author Sala Vila, Aleix
• dc.contributor.author Júlvez Calvo, Jordi
• dc.date.accessioned 2022-12-01T06:55:43Z
• dc.date.available 2022-12-01T06:55:43Z
• dc.date.issued 2023
• dc.description.abstract Omega-3 fatty acids are critical for brain function. Adolescence is increasingly believed to entail brain vulnerability to dietary intake. In contrast to the abundant research on the omega-3 docosahexaenoic acid (DHA) in cognition, research on DHA and attention in healthy adolescents is scarce. In addition, the role of alpha-linolenic acid (ALA), the vegetable omega-3 fatty acid, is unexplored. We examined associations between DHA and ALA and attention function among a healthy young population. In this cross-sectional study conducted in 372 adolescents (13.8 ± 0.9 years-old), we determined the red blood cell proportions of DHA and ALA by gas chromatography (objective biomarkers of their long-term dietary intake) and measured attention scores through the Attention Network Test. We constructed multivariable linear regression models to analyze associations, controlling for known confounders. Compared to participants at the lowest DHA tertile (reference), those at the highest DHA tertile showed significantly lower hit reaction time-standard error (higher attentiveness) (28.13 ms, 95% confidence interval [CI] = - 52.30; - 3.97), lower hit reaction time ( - 38.30 ms, 95% CI = - 73.28; - 3.33) and lower executive conflict response ( - 5.77 ms, 95% CI = - 11.44; - 0.09). In contrast, higher values were observed in those at the top tertile of ALA in hit reaction time compared to the lowest one (46.14 ms, 95% CI = 9.90; 82.34). However, a beneficial association was observed for ALA, with decreasing impulsivity index across tertiles. Overall, our results suggest that DHA (reflecting its dietary intake) is associated with attention performance in typically developing adolescents. The role of dietary ALA in attention is less clear, although higher blood levels of ALA appear to result in lower impulsivity. Future intervention studies are needed to determine the causality of these associations and to better shape dietary recommendations for brain health during the adolescence period.
• dc.format.mimetype application/pdf
• dc.identifier.citation Pinar-Martí A, Fernández-Barrés S, Gignac F, Persavento C, Delgado A, Romaguera D, Lázaro I, Ros E, López-Vicente M, Salas-Salvadó J, Sala-Vila A, Júlvez J. Red blood cell omega-3 fatty acids and attention scores in healthy adolescents. Eur Child Adolesc Psychiatry. 2023 Nov;32(11):2187-95. DOI: 10.1007/s00787-022-02064-w
• dc.identifier.doi http://dx.doi.org/10.1007/s00787-022-02064-w
• dc.identifier.issn 1018-8827
• dc.identifier.uri http://hdl.handle.net/10230/55054
• dc.language.iso eng
• dc.publisher Springer
• dc.relation.ispartof Eur Child Adolesc Psychiatry. 2023 Nov;32(11):2187-95
• dc.rights © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Adolescence
• dc.subject.keyword Alpha-linolenic acid (ALA)
• dc.subject.keyword Attention
• dc.subject.keyword Docosahexaenoic acid (DHA)
• dc.subject.keyword Omega-3
• dc.subject.keyword Polyunsaturated fatty acids
• dc.title Red blood cell omega-3 fatty acids and attention scores in healthy adolescents
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion