Estimating the dynamic early life exposure to PFOA and PFOS of the HELIX children: Emerging profiles via prenatal exposure, breastfeeding, and diet

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• dc.contributor.author Ratier, Aude
• dc.contributor.author Casas Sanahuja, Maribel
• dc.contributor.author Gražulevičienė, Regina
• dc.contributor.author Slama, Rémy
• dc.contributor.author Haug, Line Småstuen
• dc.contributor.author Thomsen, Cathrine
• dc.contributor.author Vafeiadi, Marina, 1983-
• dc.contributor.author Wright, John
• dc.contributor.author Zeman, Florence A.
• dc.contributor.author Vrijheid, Martine
• dc.contributor.author Brochot, Celine
• dc.date.accessioned 2024-07-05T06:56:25Z
• dc.date.available 2024-07-05T06:56:25Z
• dc.date.issued 2024
• dc.description.abstract In utero and children's exposure to per- and polyfluoroalkyl substances (PFAS) is a major concern in health risk assessment as early life exposures are suspected to induce adverse health effects. Our work aims to estimate children's exposure (from birth to 12 years old) to PFOA and PFOS, using a Physiologically-Based Pharmacokinetic (PBPK) modelling approach. A model for PFAS was updated to simulate the internal PFAS exposures during the in utero life and childhood, and including individual characteristics and exposure scenarios (e.g., duration of breastfeeding, weight at birth, etc.). Our approach was applied to the HELIX cohort, involving 1,239 mother-child pairs with measured PFOA and PFOS plasma concentrations at two sampling times: maternal and child plasma concentrations (6 to 12 y.o). Our model predicted an increase in plasma concentrations during fetal development and childhood until 2 y.o when the maximum concentrations were reached. Higher plasma concentrations of PFOA than PFOS were predicted until 2 y.o, and then PFOS concentrations gradually became higher than PFOA concentrations. From 2 to 8 y.o, mean concentrations decreased from 3.1 to 1.88 µg/L or ng/mL (PFOA) and from 4.77 to 3.56 µg/L (PFOS). The concentration-time profiles vary with the age and were mostly influenced by in utero exposure (on the first 4 months after birth), breastfeeding (from 5 months to 2 (PFOA) or 5 (PFOS) y.o of the children), and food intake (after 3 (PFOA) or 6 (PFOS) y.o of the children). Similar measured biomarker levels can correspond to large differences in the simulated internal exposures, highlighting the importance to investigate the children's exposure over the early life to improve exposure classification. Our approach demonstrates the possibility to simulate individual internal exposures using PBPK models when measured biomarkers are scarce, helping risk assessors in gaining insight into internal exposure during critical windows, such as early life.
• dc.description.sponsorship We acknowledge the funding from the European Community's Seventh Framework Programme (FP7/2007–2013) under Grant Agreement No 308333 – the HELIX project, the European Partnership for the Assessment of Risks from Chemicals (PARC project) founded by the European Union’s Horizon Europe research and innovation programme under Grant Agreement No 101057014, and the ministries and national agencies of the six countries involved in the funding.
• dc.format.mimetype application/pdf
• dc.identifier.citation Ratier A, Casas M, Grazuleviciene R, Slama R, Småstuen Haug L, Thomsen C, et al. Estimating the dynamic early life exposure to PFOA and PFOS of the HELIX children: Emerging profiles via prenatal exposure, breastfeeding, and diet. Environ Int. 2024 Apr;186:108621. DOI: 10.1016/j.envint.2024.108621
• dc.identifier.doi http://dx.doi.org/10.1016/j.envint.2024.108621
• dc.identifier.issn 0160-4120
• dc.identifier.uri http://hdl.handle.net/10230/60672
• dc.language.iso eng
• dc.publisher Elsevier
• dc.relation.ispartof Environ Int. 2024 Apr;186:108621
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/308333
• dc.relation.projectID info:eu-repo/grantAgreement/EC/HE/101057014
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/CEX2018-000806-S
• dc.rights © 2024 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Children
• dc.subject.keyword Human biomonitoring
• dc.subject.keyword In utero
• dc.subject.keyword Longitudinal cohorts
• dc.subject.keyword PBPK model
• dc.subject.keyword Reverse dosimetry
• dc.title Estimating the dynamic early life exposure to PFOA and PFOS of the HELIX children: Emerging profiles via prenatal exposure, breastfeeding, and diet
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion