Effect of statin therapy on SARS-CoV-2 infection-related

Masana, Luís; Correig, Eudald; Rodríguez-Borjabad, Cèlia; Anoro, Eva; Arroyo-Díaz, Juan Antonio; Jericó, Carlos; Pedragosa, Angels; Miret, Marcel·la; Näf, Silvia; Pardo, Anna; Perea, Verónica; Pérez-Bernalte, Rosa; Plana, Nuria; Ramírez-Montesinos, Rafael; Royuela, Meritxell; Soler, Cristina; Urquizu-Padilla, Maria; Pedro-Botet, Juan; The Stacov-Xula Research Group

doi:http://dx.doi.org/10.1093/ehjcvp/pvaa128

Effect of statin therapy on SARS-CoV-2 infection-related

Citation

Masana L, Correig E, Rodríguez-Borjabad C, Anoro E, Arroyo JA, Jericó C, Effect of statin therapy on SARS-CoV-2 infection-related. Eur Heart J Cardiovasc Pharmacother. 2022 Feb 16;8(2):157-64. DOI: 10.1093/ehjcvp/pvaa128

Abstract

Aim: Assessing the effect of statin therapy at hospital admission for COVID-19 on in-hospital mortality. Methods and results: Retrospective observational study. Patients taking statins were 11 years older and had significantly more comorbidities than patients who were not taking statins. A genetic matching (GM) procedure was performed prior to analysis of the mortality risk. A Cox proportional hazards model was used for the cause-specific hazard (CSH) function, and a competing-risks Fine and Gray (FG) model was also used to study the direct effects of statins on risk.Data from reverse transcription-polymerase chain reaction-confirmed 2157 SARS-CoV-2-infected patients (1234 men, 923 women; age: 67 y/o (IQR 54-78)) admitted to the hospital were retrieved from the clinical records in anonymized manner. 353 deaths occurred. 581 patients were taking statins. Univariate test after GM showed a significantly lower mortality rate in patients on statin therapy than the matched non-statin group (19.8% vs. 25.4%, χ2 with Yates continuity correction: p = 0.027). The mortality rate was even lower in patients (n = 336) who maintained their statin treatments during hospitalization compared to the GM non-statin group (17.4%; p = 0.045). The Cox model applied to the CSH function (HR = 0.58(CI: 0.39-0.89); p = 0.01) and the competing risks FG model (HR = 0.60(CI: 0.39-0.92); p = 0.02) suggest that statins are associated with reduced COVID-19-related mortality. Conclusions: A lower SARS-CoV-2 infection-related mortality was observed in patients treated with statin therapy prior to hospitalization. Statin therapy should not be discontinued due to the global concern of the pandemic or in patients hospitalized for COVID-19.