Electric field causes volumetric changes in the human brain

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• dc.contributor.author Argyelan, Miklos
• dc.contributor.author Pujol Nuez, Jesús
• dc.contributor.author Abbott, Christopher
• dc.date.accessioned 2021-03-01T07:52:12Z
• dc.date.available 2021-03-01T07:52:12Z
• dc.date.issued 2019
• dc.description.abstract Recent longitudinal neuroimaging studies in patients with electroconvulsive therapy (ECT) suggest local effects of electric stimulation (lateralized) occur in tandem with global seizure activity (generalized). We used electric field (EF) modeling in 151 ECT treated patients with depression to determine the regional relationships between EF, unbiased longitudinal volume change, and antidepressant response across 85 brain regions. The majority of regional volumes increased significantly, and volumetric changes correlated with regional electric field (t = 3.77, df = 83, r = 0.38, p=0.0003). After controlling for nuisance variables (age, treatment number, and study site), we identified two regions (left amygdala and left hippocampus) with a strong relationship between EF and volume change (FDR corrected p<0.01). However, neither structural volume changes nor electric field was associated with antidepressant response. In summary, we showed that high electrical fields are strongly associated with robust volume changes in a dose-dependent fashion.
• dc.format.mimetype application/pdf
• dc.identifier.citation Argyelan M, Oltedal L, Deng ZD, Wade B, Bikson M, Joanlanne A, et al. Electric field causes volumetric changes in the human brain. Elife. 2019 Oct 23; 8: e49115. DOI: 10.7554/eLife.49115
• dc.identifier.doi http://dx.doi.org/10.7554/eLife.49115
• dc.identifier.issn 2050-084X
• dc.identifier.uri http://hdl.handle.net/10230/46617
• dc.language.iso eng
• dc.publisher eLife
• dc.rights This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication. http://creativecommons.org/publicdomain/zero/1.0/
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/publicdomain/zero/1.0/
• dc.subject.keyword ECT
• dc.subject.keyword Depression
• dc.subject.keyword Electric field modeling
• dc.subject.keyword Human
• dc.subject.keyword Human biology
• dc.subject.keyword Medicine
• dc.subject.keyword Neuroimaging
• dc.subject.keyword Volume change
• dc.title Electric field causes volumetric changes in the human brain
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion