Response to hyperosmotic stress

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• dc.contributor.author Saito, Haruoca
• dc.contributor.author Posas Garriga, Francescca
• dc.date.accessioned 2015-12-09T15:21:50Z
• dc.date.available 2015-12-09T15:21:50Z
• dc.date.issued 2012
• dc.description.abstract An appropriate response and adaptation to hyperosmolarity, i.e., an external osmolarity that is higher than the physiological range, can be a matter of life or death for all cells. It is especially important for free-living organisms such as the yeast Saccharomyces cerevisiae. When exposed to hyperosmotic stress, the yeast initiates a complex adaptive program that includes temporary arrest of cell-cycle progression, adjustment of transcription and translation patterns, and the synthesis and retention of the compatible osmolyte glycerol. These adaptive responses are mostly governed by the high osmolarity glycerol (HOG) pathway, which is composed of membrane-associated osmosensors, an intracellular signaling pathway whose core is the Hog1 MAP kinase (MAPK) cascade, and cytoplasmic and nuclear effector functions. The entire pathway is conserved in diverse fungal species, while the Hog1 MAPK cascade is conserved even in higher eukaryotes including humans. This conservation is illustrated by the fact that the mammalian stress-responsive p38 MAPK can rescue the osmosensitivity of hog1Δ mutations in response to hyperosmotic challenge. As the HOG pathway is one of the best-understood eukaryotic signal transduction pathways, it is useful not only as a model for analysis of osmostress responses, but also as a model for mathematical analysis of signal transduction pathways. In this review, we have summarized the current understanding of both the upstream signaling mechanism and the downstream adaptive responses to hyperosmotic stress in yeast.ca
• dc.description.sponsorship The laboratory of H.S. is supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan. The laboratory of F.P. is supported by grants from the Ministerio de Economia y Competitividad (Spanish Government), the Consolider Ingenio 2010 Programme, and a FP7 UNICELLSYS grant. F.P. is also supported by the Fundación Marcelino Botín and by the Acadèmia program from Institució Catalana de Recerca i Estudis Avançats (Generalitat de Catalunya).en
• dc.format.mimetype application/pdfca
• dc.identifier.citation Saito H, Posas F. Response to hyperosmotic stress. Genetics. 2012;192(2):289-318. DOI: 10.1534/genetics.112.140863ca
• dc.identifier.doi http://dx.doi.org/10.1534/genetics.112.140863
• dc.identifier.issn 0016-6731
• dc.identifier.uri http://hdl.handle.net/10230/25359
• dc.language.iso engca
• dc.publisher Genetics Society of Americaca
• dc.relation.ispartof Genetics. 2012;192(2):289-318
• dc.relation.projectID info:eu-repo/grantAgreement/EC/FP7/201142
• dc.rights © 2012 Saito et al. This is an open-access article.ca
• dc.rights.accessRights info:eu-repo/semantics/openAccessca
• dc.subject.other Saccharomyces cerevisiae -- Fisiologiaca
• dc.subject.other Proteïnes quinasesca
• dc.title Response to hyperosmotic stressca
• dc.type info:eu-repo/semantics/articleca
• dc.type.version info:eu-repo/semantics/publishedVersionca