Zinc favors triple-negative breast cancer's microenvironment modulation and cell plasticity

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• dc.contributor.author Vogel-González, Marina
• dc.contributor.author Musa-Afaneh, Dunia
• dc.contributor.author Rivera Gil, Pilar, 1976-
• dc.contributor.author Vicente García, Rubén, 1978-
• dc.date.accessioned 2021-10-15T06:17:51Z
• dc.date.available 2021-10-15T06:17:51Z
• dc.date.issued 2021
• dc.description.abstract Triple-negative breast cancer (TNBC) tends to metastasize to the brain, a step that worsens the patient's prognosis. The specific hallmarks that determine successful metastasis are motility and invasion, microenvironment modulation, plasticity, and colonization. Zinc, an essential trace element, has been shown to be involved in all of these processes. In this work, we focus our attention on the potential role of zinc during TNBC metastasis. We used MDA-MB-BrM2 (BrM2) cells, a brain metastasis model derived from the parental TNBC cell line MDA-MB-231. Our studies show that BrM2 cells had double the zinc content of MDA-MB-231 cells. Moreover, exploring different metastatic hallmarks, we found that the zinc concentration is especially important in the microenvironment modulation of brain metastatic cells, enhancing the expression of SerpinB2. Furthermore, we show that zinc promotes the tumorigenic capacity of breast cancer stem cells. In addition, by causing a disturbance in MDA-MB-231 zinc homeostasis by overexpressing the Zip4 transporter, we were able to increase tumorigenicity. Nevertheless, this strategy did not completely recapitulate the BrM2 metastatic phenotype. Altogether, our work suggests that zinc plays an important role in the transformative steps that tumoral cells take to acquire tumorigenic potential and niche specificity.
• dc.description.sponsorship This work was supported by the Spanish Ministry of Science and Innovation through grant PID2019-106755RB-I00/AEI/10.13039/501100011033.
• dc.format.mimetype application/pdf
• dc.identifier.citation Vogel-González M, Musa-Afaneh D, Rivera Gil P, Vicente R. Zinc favors triple-negative breast cancer's microenvironment modulation and cell plasticity. Int J Mol Sci. 2021;22(17):9188. DOI: 10.3390/ijms22179188
• dc.identifier.doi http://dx.doi.org/10.3390/ijms22179188
• dc.identifier.issn 1422-0067
• dc.identifier.uri http://hdl.handle.net/10230/48662
• dc.language.iso eng
• dc.publisher MDPI
• dc.relation.ispartof Int J Mol Sci. 2021;22(17):9188
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/PID2019-106755RB-I00
• dc.rights © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Zip4
• dc.subject.keyword Metastasis
• dc.subject.keyword Triple-negative breast cancer
• dc.subject.keyword Zinc
• dc.title Zinc favors triple-negative breast cancer's microenvironment modulation and cell plasticity
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion