2D printed multicellular devices performing digital and analogue computation

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• dc.contributor.author Mogas Díez, Sira
• dc.contributor.author González Flo, Eva, 1993-
• dc.contributor.author Macía, Javier
• dc.date.accessioned 2021-04-12T07:07:16Z
• dc.date.available 2021-04-12T07:07:16Z
• dc.date.issued 2021
• dc.description.abstract Much effort has been expended on building cellular computational devices for different applications. Despite the significant advances, there are still several addressable restraints to achieve the necessary technological transference. These improvements will ease the development of end-user applications working out of the lab. In this study, we propose a methodology for the construction of printable cellular devices, digital or analogue, for different purposes. These printable devices are designed to work in a 2D surface, in which the circuit information is encoded in the concentration of a biological signal, the so-called carrying signal. This signal diffuses through the 2D surface and thereby interacts with different device components. These components are distributed in a specific spatial arrangement and perform the computation by modulating the level of the carrying signal in response to external inputs, determining the final output. For experimental validation, 2D cellular circuits are printed on a paper surface by using a set of cellular inks. As a proof-of-principle, we have printed and analysed both digital and analogue circuits using the same set of cellular inks but with different spatial topologies. The proposed methodology can open the door to a feasible and reliable industrial production of cellular circuits for multiple applications.
• dc.description.sponsorship Funding for this study and for the open access charge was in the form of grants from the Spanish Ministry of Economy and Competitiveness [MINECO AEI-FIS2017-88786-R and FEDER] and UPF INNOValora 2019 [INNOV19-01-1]. This work was supported by “Unidad de Excelencia María de Maeztu” and funded by the AEI (CEX2018-000792-M). E.G.F. is a recipient of an FI-DGR (2017 FI_B 00018) fellowship.
• dc.format.mimetype application/pdf
• dc.identifier.citation Mogas-Díez S, Gonzalez-Flo E, Macía J. 2D printed multicellular devices performing digital and analogue computation. Nat Commun. 2021; 12(1):1679. DOI: 10.1038/s41467-021-21967-x
• dc.identifier.doi http://dx.doi.org/10.1038/s41467-021-21967-x
• dc.identifier.issn 2041-1723
• dc.identifier.uri http://hdl.handle.net/10230/47085
• dc.language.iso eng
• dc.publisher Nature Research
• dc.relation.ispartof Nat Commun. 2021; 12(1):1679
• dc.relation.projectID info:eu-repo/grantAgreement/ES/2PE/FIS2017-88786-R
• dc.rights © The Author(s) 2021. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
• dc.rights.accessRights info:eu-repo/semantics/openAccess
• dc.rights.uri http://creativecommons.org/licenses/by/4.0/
• dc.subject.keyword Assay systems
• dc.subject.keyword Synthetic biology
• dc.title 2D printed multicellular devices performing digital and analogue computation
• dc.type info:eu-repo/semantics/article
• dc.type.version info:eu-repo/semantics/publishedVersion